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The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity.

Abstract

This study was designed to investigate the qualitative and quantitative changes in brain tissue following aluminum chloride (AlCl(3)) administration and to determine whether boric acid (BA) has a protective effect against brain damage induced by AlCl( 3). For this aim, Sprague-Dawley rats were randomly separated into eight groups: (1) control, (2) AlCl(3) (5 mg/kg/day), (3, 4 and 5) BA (3.25, 36 and 58.5 mg/kg/day), (6, 7 and 8) AlCl(3) (5 mg/kg/day) plus BA (3.25, 36 and 58.5 mg/kg/day). After the animals were killed, the total numbers of neuron in the brain of all groups were determined using an unbiased stereological analysis. In addition to the stereological analysis, all brains were examined histopathologically by using light and electron microscopy. The stereological and histopathological results indicated a high damage of the rat brain tissues in the AlCl(3) and AlCl(3) + high dose BA (36 and 58.5) treatment groups. However, protective effects on neuron were observed in the AlCl(3) + low dose BA (3.25) group when compared other AlCl(3) groups. Our stereological and histopathological findings show that low-dose BA, as a proteasome inhibitor, can decrease the adverse effects of AlCl(3) on the cerebral cortex.

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  • Publisher Full Text
  • Authors

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    Source

    Toxicology and industrial health 27:8 2011 Sep pg 700-10

    MeSH

    Aluminum Compounds
    Analysis of Variance
    Animals
    Boric Acids
    Brain Diseases
    Cerebral Cortex
    Chlorides
    Cysteine Proteinase Inhibitors
    Dose-Response Relationship, Drug
    Histocytochemistry
    Male
    Microscopy, Electron
    Necrosis
    Neurons
    Neuroprotective Agents
    Neurotoxicity Syndromes
    Rats
    Rats, Sprague-Dawley

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21543463

    Citation

    TY - JOUR T1 - The neuroprotective role of boric acid on aluminum chloride-induced neurotoxicity. AU - Colak,Suat, AU - Geyikoglu,Fatime, AU - Keles,Osman Nuri, AU - Türkez,Hasan, AU - Topal,Ahmet, AU - Unal,Bünyami, Y1 - 2011/05/04/ PY - 2011/5/4/aheadofprint PY - 2011/5/6/entrez PY - 2011/5/6/pubmed PY - 2012/2/18/medline SP - 700 EP - 10 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 27 IS - 8 N2 - This study was designed to investigate the qualitative and quantitative changes in brain tissue following aluminum chloride (AlCl(3)) administration and to determine whether boric acid (BA) has a protective effect against brain damage induced by AlCl( 3). For this aim, Sprague-Dawley rats were randomly separated into eight groups: (1) control, (2) AlCl(3) (5 mg/kg/day), (3, 4 and 5) BA (3.25, 36 and 58.5 mg/kg/day), (6, 7 and 8) AlCl(3) (5 mg/kg/day) plus BA (3.25, 36 and 58.5 mg/kg/day). After the animals were killed, the total numbers of neuron in the brain of all groups were determined using an unbiased stereological analysis. In addition to the stereological analysis, all brains were examined histopathologically by using light and electron microscopy. The stereological and histopathological results indicated a high damage of the rat brain tissues in the AlCl(3) and AlCl(3) + high dose BA (36 and 58.5) treatment groups. However, protective effects on neuron were observed in the AlCl(3) + low dose BA (3.25) group when compared other AlCl(3) groups. Our stereological and histopathological findings show that low-dose BA, as a proteasome inhibitor, can decrease the adverse effects of AlCl(3) on the cerebral cortex. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/21543463/The_neuroprotective_role_of_boric_acid_on_aluminum_chloride_induced_neurotoxicity_ L2 - http://tih.sagepub.com/cgi/pmidlookup?view=long&pmid=21543463 ER -