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Frequency doubling technology for earlier detection of functional damage in standard automated perimetry-normal hemifield in glaucoma with low-to-normal pressure.
J Glaucoma. 2012 Jan; 21(1):22-6.JG

Abstract

PURPOSE

To compare the longitudinal change of frequency doubling technology (FDT) perimetry and standard automated perimetry (SAP) results in SAP-normal hemifield in open-angle glaucoma (OAG) eyes with low-to-normal intraocular pressure (IOP).

MATERIALS AND METHODS

FDT perimetry with the N-30 full threshold protocol and SAP using the Humphrey Field Analyzer with the 30-2 Swedish Interactive Threshold Algorithm-standard protocol were periodically performed for at least 3 years in 39 eyes of 39 OAG patients with low-to-normal IOP and visual field damage confined to only one hemifield. The time courses of the mean of the threshold values of FDT and the mean of total deviations (TDs) in SAP-normal and SAP-abnormal fields were analyzed using a linear mixed model.

RESULTS

The average follow-up was 4.9 years and the average IOP during follow-up was 12.6 mm Hg with or without medication. The aging effect-corrected rate of change in the mean FDT threshold values was significantly negative (P=0.004) in the SAP-normal hemifield, whereas that of mean of TD values by SAP did not significantly differ. In the SAP-abnormal hemifield, the rate of change was significantly negative for both tests (P<0.001). The mean of the slope of the mean TD values in the SAP-abnormal hemifield was significantly more negative than that in the SAP-normal hemifield (P=0.011), whereas that of the mean FDT threshold values showed no significant difference between the 2 hemifields.

CONCLUSIONS

FDT is useful for monitoring functional damage in the SAP-normal hemifield in OAG eyes with low-to-normal IOP.

Authors+Show Affiliations

Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. snakagawa-tky@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21543995

Citation

Nakagawa, Suguru, et al. "Frequency Doubling Technology for Earlier Detection of Functional Damage in Standard Automated Perimetry-normal Hemifield in Glaucoma With Low-to-normal Pressure." Journal of Glaucoma, vol. 21, no. 1, 2012, pp. 22-6.
Nakagawa S, Murata H, Saito H, et al. Frequency doubling technology for earlier detection of functional damage in standard automated perimetry-normal hemifield in glaucoma with low-to-normal pressure. J Glaucoma. 2012;21(1):22-6.
Nakagawa, S., Murata, H., Saito, H., Nakahara, H., Mataki, N., Tomidokoro, A., Iwase, A., & Araie, M. (2012). Frequency doubling technology for earlier detection of functional damage in standard automated perimetry-normal hemifield in glaucoma with low-to-normal pressure. Journal of Glaucoma, 21(1), 22-6. https://doi.org/10.1097/IJG.0b013e318202777e
Nakagawa S, et al. Frequency Doubling Technology for Earlier Detection of Functional Damage in Standard Automated Perimetry-normal Hemifield in Glaucoma With Low-to-normal Pressure. J Glaucoma. 2012;21(1):22-6. PubMed PMID: 21543995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frequency doubling technology for earlier detection of functional damage in standard automated perimetry-normal hemifield in glaucoma with low-to-normal pressure. AU - Nakagawa,Suguru, AU - Murata,Hiroshi, AU - Saito,Hitomi, AU - Nakahara,Hisae, AU - Mataki,Naomi, AU - Tomidokoro,Atsuo, AU - Iwase,Aiko, AU - Araie,Makoto, PY - 2011/5/6/entrez PY - 2011/5/6/pubmed PY - 2012/3/16/medline SP - 22 EP - 6 JF - Journal of glaucoma JO - J Glaucoma VL - 21 IS - 1 N2 - PURPOSE: To compare the longitudinal change of frequency doubling technology (FDT) perimetry and standard automated perimetry (SAP) results in SAP-normal hemifield in open-angle glaucoma (OAG) eyes with low-to-normal intraocular pressure (IOP). MATERIALS AND METHODS: FDT perimetry with the N-30 full threshold protocol and SAP using the Humphrey Field Analyzer with the 30-2 Swedish Interactive Threshold Algorithm-standard protocol were periodically performed for at least 3 years in 39 eyes of 39 OAG patients with low-to-normal IOP and visual field damage confined to only one hemifield. The time courses of the mean of the threshold values of FDT and the mean of total deviations (TDs) in SAP-normal and SAP-abnormal fields were analyzed using a linear mixed model. RESULTS: The average follow-up was 4.9 years and the average IOP during follow-up was 12.6 mm Hg with or without medication. The aging effect-corrected rate of change in the mean FDT threshold values was significantly negative (P=0.004) in the SAP-normal hemifield, whereas that of mean of TD values by SAP did not significantly differ. In the SAP-abnormal hemifield, the rate of change was significantly negative for both tests (P<0.001). The mean of the slope of the mean TD values in the SAP-abnormal hemifield was significantly more negative than that in the SAP-normal hemifield (P=0.011), whereas that of the mean FDT threshold values showed no significant difference between the 2 hemifields. CONCLUSIONS: FDT is useful for monitoring functional damage in the SAP-normal hemifield in OAG eyes with low-to-normal IOP. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/21543995/Frequency_doubling_technology_for_earlier_detection_of_functional_damage_in_standard_automated_perimetry_normal_hemifield_in_glaucoma_with_low_to_normal_pressure_ L2 - https://doi.org/10.1097/IJG.0b013e318202777e DB - PRIME DP - Unbound Medicine ER -