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Cigarette smoking and the risk of incident and fatal melanoma in a large prospective cohort study.
Cancer Causes Control. 2011 Jun; 22(6):937-42.CC

Abstract

OBJECTIVE

Previous studies suggest that smoking may be inversely associated with risk of melanoma. We attempted to replicate this finding using data from the Cancer Prevention Study II (CPS-II) and CPS-II Nutrition cohort, two large prospective cohort studies of cancer mortality and incidence, respectively, with long-term follow-up.

METHODS

Cox proportional hazards regression analysis was used to examine the association between smoking status and risk of melanoma mortality and incidence among Caucasians in these cohorts. Analyses were adjusted by age, occupation, latitude and educational status.

RESULTS

The incidence rate of melanoma was lower in current than never smokers in both men [hazard ratio (HR): 0.70, 95% confidence interval (CI): (0.48-1.02)] and women [0.50 (0.30-0.83)]; incidence was not lower in former than in never smokers for either sex. The death rate from melanoma was lower in male current than never smokers [0.77 (0.62-0.94)], and in male and female former smokers [0.86 (0.73-1.01)] and [0.83 (0.65-1.06)], respectively. No trends in incidence or mortality were observed in male or female current smokers with years of smoking or cigarettes per day.

CONCLUSIONS

This study provides limited support for the hypothesis that smoking reduces melanoma risk. The inconsistent results by smoking status and lack of clear dose-response relationships weaken the evidence for causality.

Authors+Show Affiliations

Department of Epidemiology Research, American Cancer Society, Atlanta, GA, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21544529

Citation

DeLancey, John Oliver, et al. "Cigarette Smoking and the Risk of Incident and Fatal Melanoma in a Large Prospective Cohort Study." Cancer Causes & Control : CCC, vol. 22, no. 6, 2011, pp. 937-42.
DeLancey JO, Hannan LM, Gapstur SM, et al. Cigarette smoking and the risk of incident and fatal melanoma in a large prospective cohort study. Cancer Causes Control. 2011;22(6):937-42.
DeLancey, J. O., Hannan, L. M., Gapstur, S. M., & Thun, M. J. (2011). Cigarette smoking and the risk of incident and fatal melanoma in a large prospective cohort study. Cancer Causes & Control : CCC, 22(6), 937-42. https://doi.org/10.1007/s10552-011-9766-z
DeLancey JO, et al. Cigarette Smoking and the Risk of Incident and Fatal Melanoma in a Large Prospective Cohort Study. Cancer Causes Control. 2011;22(6):937-42. PubMed PMID: 21544529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cigarette smoking and the risk of incident and fatal melanoma in a large prospective cohort study. AU - DeLancey,John Oliver, AU - Hannan,Lindsay M, AU - Gapstur,Susan M, AU - Thun,Michael J, Y1 - 2011/05/05/ PY - 2010/08/06/received PY - 2011/03/28/accepted PY - 2011/5/6/entrez PY - 2011/5/6/pubmed PY - 2011/9/29/medline SP - 937 EP - 42 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 22 IS - 6 N2 - OBJECTIVE: Previous studies suggest that smoking may be inversely associated with risk of melanoma. We attempted to replicate this finding using data from the Cancer Prevention Study II (CPS-II) and CPS-II Nutrition cohort, two large prospective cohort studies of cancer mortality and incidence, respectively, with long-term follow-up. METHODS: Cox proportional hazards regression analysis was used to examine the association between smoking status and risk of melanoma mortality and incidence among Caucasians in these cohorts. Analyses were adjusted by age, occupation, latitude and educational status. RESULTS: The incidence rate of melanoma was lower in current than never smokers in both men [hazard ratio (HR): 0.70, 95% confidence interval (CI): (0.48-1.02)] and women [0.50 (0.30-0.83)]; incidence was not lower in former than in never smokers for either sex. The death rate from melanoma was lower in male current than never smokers [0.77 (0.62-0.94)], and in male and female former smokers [0.86 (0.73-1.01)] and [0.83 (0.65-1.06)], respectively. No trends in incidence or mortality were observed in male or female current smokers with years of smoking or cigarettes per day. CONCLUSIONS: This study provides limited support for the hypothesis that smoking reduces melanoma risk. The inconsistent results by smoking status and lack of clear dose-response relationships weaken the evidence for causality. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/21544529/Cigarette_smoking_and_the_risk_of_incident_and_fatal_melanoma_in_a_large_prospective_cohort_study_ L2 - https://doi.org/10.1007/s10552-011-9766-z DB - PRIME DP - Unbound Medicine ER -