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Predictors of invasion and axillary lymph node metastasis in patients with a core biopsy diagnosis of ductal carcinoma in situ: an analysis of 255 cases.
Breast J. 2011 May-Jun; 17(3):223-9.BJ

Abstract

The diagnosis of ductal carcinoma in situ (DCIS) using core biopsy does not ensure the absence of invasion on final excision. We performed a retrospective analysis of 255 patients with DCIS who had subsequent excision. Clinical, radiologic, and pathologic findings were correlated with risk of invasion and sentinel lymph node (SLN) metastasis. Of 255 patients with DCIS, 199 had definitive surgery and 52 (26%) had invasive ductal carcinoma (IDC) on final excision. Extent of abnormal microcalcification on mammography, and presence of a radiologic/palpable mass and solid type of DCIS were significantly associated with invasion on final excision. Sentinel lymph node biopsy was performed in 131 (65.8%) patients of whom 18 (13.4%) had metastasis. Size of IDC and extent of DCIS on final pathology were significantly associated with positive SLN. Micrometastasis and isolated tumor cells comprised majority (71.4%) of the metastases in DCIS. SLN biopsy should be considered in those with high risk DCIS.

Authors+Show Affiliations

Department of Pathology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9073, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21545433

Citation

Han, Jeong S., et al. "Predictors of Invasion and Axillary Lymph Node Metastasis in Patients With a Core Biopsy Diagnosis of Ductal Carcinoma in Situ: an Analysis of 255 Cases." The Breast Journal, vol. 17, no. 3, 2011, pp. 223-9.
Han JS, Molberg KH, Sarode V. Predictors of invasion and axillary lymph node metastasis in patients with a core biopsy diagnosis of ductal carcinoma in situ: an analysis of 255 cases. Breast J. 2011;17(3):223-9.
Han, J. S., Molberg, K. H., & Sarode, V. (2011). Predictors of invasion and axillary lymph node metastasis in patients with a core biopsy diagnosis of ductal carcinoma in situ: an analysis of 255 cases. The Breast Journal, 17(3), 223-9. https://doi.org/10.1111/j.1524-4741.2011.01069.x
Han JS, Molberg KH, Sarode V. Predictors of Invasion and Axillary Lymph Node Metastasis in Patients With a Core Biopsy Diagnosis of Ductal Carcinoma in Situ: an Analysis of 255 Cases. Breast J. 2011 May-Jun;17(3):223-9. PubMed PMID: 21545433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of invasion and axillary lymph node metastasis in patients with a core biopsy diagnosis of ductal carcinoma in situ: an analysis of 255 cases. AU - Han,Jeong S, AU - Molberg,Kyle H, AU - Sarode,Venetia, Y1 - 2011/03/24/ PY - 2011/5/7/entrez PY - 2011/5/7/pubmed PY - 2011/8/30/medline SP - 223 EP - 9 JF - The breast journal JO - Breast J VL - 17 IS - 3 N2 - The diagnosis of ductal carcinoma in situ (DCIS) using core biopsy does not ensure the absence of invasion on final excision. We performed a retrospective analysis of 255 patients with DCIS who had subsequent excision. Clinical, radiologic, and pathologic findings were correlated with risk of invasion and sentinel lymph node (SLN) metastasis. Of 255 patients with DCIS, 199 had definitive surgery and 52 (26%) had invasive ductal carcinoma (IDC) on final excision. Extent of abnormal microcalcification on mammography, and presence of a radiologic/palpable mass and solid type of DCIS were significantly associated with invasion on final excision. Sentinel lymph node biopsy was performed in 131 (65.8%) patients of whom 18 (13.4%) had metastasis. Size of IDC and extent of DCIS on final pathology were significantly associated with positive SLN. Micrometastasis and isolated tumor cells comprised majority (71.4%) of the metastases in DCIS. SLN biopsy should be considered in those with high risk DCIS. SN - 1524-4741 UR - https://www.unboundmedicine.com/medline/citation/21545433/Predictors_of_invasion_and_axillary_lymph_node_metastasis_in_patients_with_a_core_biopsy_diagnosis_of_ductal_carcinoma_in_situ:_an_analysis_of_255_cases_ L2 - https://doi.org/10.1111/j.1524-4741.2011.01069.x DB - PRIME DP - Unbound Medicine ER -