TY - JOUR T1 - Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system. AU - Cerný,Dalibor, AU - Lekić,Nataša, AU - Váňová,Kateřina, AU - Muchová,Lucie, AU - Hořínek,Aleš, AU - Kmoníčková,Eva, AU - Zídek,Zdeněk, AU - Kameníková,Ludmila, AU - Farghali,Hassan, Y1 - 2011/04/30/ PY - 2011/02/28/received PY - 2011/04/04/revised PY - 2011/04/15/accepted PY - 2011/5/7/entrez PY - 2011/5/7/pubmed PY - 2011/12/17/medline SP - 786 EP - 91 JF - Fitoterapia JO - Fitoterapia VL - 82 IS - 5 N2 - This work studied a relationship between HO-1/CO system and lipid peroxidation with consequent effects on liver functions and NOS-2. We focused on curcumin pretreatment in rat toxic model of d-galactosamine and lipopolysaccharide. Hepatocyte viability, lipid peroxidation, antioxidant status, ALT and AST were evaluated. HO-1 and NOS-2 expressions and respective enzyme activity were determined. Curcumin caused decreases in ALT and AST levels as well as in lipid peroxidation. Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions. In conclusion, the tuning of CO/NO pathways is important in shedding light on curcumin's cytoprotective effects in this model. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/21545828/Hepatoprotective_effect_of_curcumin_in_lipopolysaccharide/_galactosamine_model_of_liver_injury_in_rats:_relationship_to_HO_1/CO_antioxidant_system_ DB - PRIME DP - Unbound Medicine ER -