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Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients.
Ann Clin Biochem. 2011 Jul; 48(Pt 4):344-51.AC

Abstract

BACKGROUND

Asthma is associated with increased inflammation, oxidative stress and abnormal immune system function. We determined the distributions of several essential trace minerals and assessed their relationships to factors that are associated with the pathophysiological status of patients with mild/moderate asthma.

METHODS

We enrolled 25 asthmatic patients and 25 healthy subjects. We measured: blood trace minerals, zinc (Zn), copper (Cu) and selenium (Se); oxidative stress markers thiobarbituric acid reactive substances (TBARS); antioxidant enzyme activities; percentages of CD4 and CD8 lymphocyte subsets; high-sensitivity C-reactive protein (hs-CRP); and a lung function index (FEV1/FVC%).

RESULTS

Compared with healthy subjects, asthmatics had lower concentrations of Zn and Se; higher Cu concentrations, and Cu/Zn and Cu/Se ratios; and lower antioxidant enzyme glutathione peroxidase (GPx), glutathione reductase (GR) and catalase activities. Significantly increased concentrations of hs-CRP, TBARS and CD4/CD8 lymphocyte ratios were also observed. Furthermore, plasma TBARS or hs-CRP concentrations were negatively associated with Se concentrations, but were positively associated with Cu/Se ratios. CD4/CD8 lymphocyte ratios were inversely correlated with Se, while it was positively correlated with Cu/Se ratio. FEV1/FVC% was also significantly correlated with Se concentrations, and Cu/Se and Cu/Zn ratios.

CONCLUSIONS

Abnormal distributions of these trace minerals may aggravate oxidative damage and inflammation, increased CD4/CD8 lymphocyte ratios and decreased lung function in asthma.

Authors+Show Affiliations

Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21546427

Citation

Guo, Chih-Hung, et al. "Role of Certain Trace Minerals in Oxidative Stress, Inflammation, CD4/CD8 Lymphocyte Ratios and Lung Function in Asthmatic Patients." Annals of Clinical Biochemistry, vol. 48, no. Pt 4, 2011, pp. 344-51.
Guo CH, Liu PJ, Hsia S, et al. Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients. Ann Clin Biochem. 2011;48(Pt 4):344-51.
Guo, C. H., Liu, P. J., Hsia, S., Chuang, C. J., & Chen, P. C. (2011). Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients. Annals of Clinical Biochemistry, 48(Pt 4), 344-51. https://doi.org/10.1258/acb.2011.010266
Guo CH, et al. Role of Certain Trace Minerals in Oxidative Stress, Inflammation, CD4/CD8 Lymphocyte Ratios and Lung Function in Asthmatic Patients. Ann Clin Biochem. 2011;48(Pt 4):344-51. PubMed PMID: 21546427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of certain trace minerals in oxidative stress, inflammation, CD4/CD8 lymphocyte ratios and lung function in asthmatic patients. AU - Guo,Chih-Hung, AU - Liu,Po-Jen, AU - Hsia,Simon, AU - Chuang,Chia-Ju, AU - Chen,Pei-Chung, Y1 - 2011/05/05/ PY - 2011/5/7/entrez PY - 2011/5/7/pubmed PY - 2011/11/2/medline SP - 344 EP - 51 JF - Annals of clinical biochemistry JO - Ann Clin Biochem VL - 48 IS - Pt 4 N2 - BACKGROUND: Asthma is associated with increased inflammation, oxidative stress and abnormal immune system function. We determined the distributions of several essential trace minerals and assessed their relationships to factors that are associated with the pathophysiological status of patients with mild/moderate asthma. METHODS: We enrolled 25 asthmatic patients and 25 healthy subjects. We measured: blood trace minerals, zinc (Zn), copper (Cu) and selenium (Se); oxidative stress markers thiobarbituric acid reactive substances (TBARS); antioxidant enzyme activities; percentages of CD4 and CD8 lymphocyte subsets; high-sensitivity C-reactive protein (hs-CRP); and a lung function index (FEV1/FVC%). RESULTS: Compared with healthy subjects, asthmatics had lower concentrations of Zn and Se; higher Cu concentrations, and Cu/Zn and Cu/Se ratios; and lower antioxidant enzyme glutathione peroxidase (GPx), glutathione reductase (GR) and catalase activities. Significantly increased concentrations of hs-CRP, TBARS and CD4/CD8 lymphocyte ratios were also observed. Furthermore, plasma TBARS or hs-CRP concentrations were negatively associated with Se concentrations, but were positively associated with Cu/Se ratios. CD4/CD8 lymphocyte ratios were inversely correlated with Se, while it was positively correlated with Cu/Se ratio. FEV1/FVC% was also significantly correlated with Se concentrations, and Cu/Se and Cu/Zn ratios. CONCLUSIONS: Abnormal distributions of these trace minerals may aggravate oxidative damage and inflammation, increased CD4/CD8 lymphocyte ratios and decreased lung function in asthma. SN - 1758-1001 UR - https://www.unboundmedicine.com/medline/citation/21546427/Role_of_certain_trace_minerals_in_oxidative_stress_inflammation_CD4/CD8_lymphocyte_ratios_and_lung_function_in_asthmatic_patients_ L2 - https://journals.sagepub.com/doi/10.1258/acb.2011.010266?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -