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Enhanced solubility and bioavailability of flurbiprofen by cycloamylose.
Arch Pharm Res. 2011 Mar; 34(3):391-7.AP

Abstract

The effect of cycloamylose on the aqueous solubility of flurbiprofen was investigated. To improve the solubility and bioavailability of flurbiprofen (poor water solubility), a solid dispersion was spray dried with a solution of flurbiprofen and cycloamylose at a weight ratio of 1:1. The physicochemical properties of solid dispersions were investigated using SEM, DSC, and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with a commercial product. Cycloamylose increased solubility of flurbiprofen approximately 12-fold and dissolution of it by 2-fold. Flurbiprofen was present in an unchanged crystalline state, and cycloamylose was a solubilizing agent for flurbiprofen in this solid dispersion. Furthermore, the dispersion gave higher AUC and C(max) values compared with the commercial product, indicating that it improved the oral bioavailability of flurbiprofen in rats. Thus, the solid dispersion may be useful to deliver flurbiprofen with enhanced bioavailability without changes in crystalline structure.

Authors+Show Affiliations

Department of Food Engineering, Dankook University, Cheonan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21547670

Citation

Baek, Hyung Hee, et al. "Enhanced Solubility and Bioavailability of Flurbiprofen By Cycloamylose." Archives of Pharmacal Research, vol. 34, no. 3, 2011, pp. 391-7.
Baek HH, Kwon SY, Rho SJ, et al. Enhanced solubility and bioavailability of flurbiprofen by cycloamylose. Arch Pharm Res. 2011;34(3):391-7.
Baek, H. H., Kwon, S. Y., Rho, S. J., Lee, W. S., Yang, H. J., Hah, J. M., Choi, H. G., Kim, Y. R., & Yong, C. S. (2011). Enhanced solubility and bioavailability of flurbiprofen by cycloamylose. Archives of Pharmacal Research, 34(3), 391-7. https://doi.org/10.1007/s12272-011-0306-x
Baek HH, et al. Enhanced Solubility and Bioavailability of Flurbiprofen By Cycloamylose. Arch Pharm Res. 2011;34(3):391-7. PubMed PMID: 21547670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced solubility and bioavailability of flurbiprofen by cycloamylose. AU - Baek,Hyung Hee, AU - Kwon,So Young, AU - Rho,Shin-Joung, AU - Lee,Won Seok, AU - Yang,Ho-Joon, AU - Hah,Jung-Mi, AU - Choi,Han-Gon, AU - Kim,Yong-Ro, AU - Yong,Chul Soon, Y1 - 2011/05/06/ PY - 2010/08/25/received PY - 2010/11/30/accepted PY - 2010/11/29/revised PY - 2011/5/7/entrez PY - 2011/5/7/pubmed PY - 2011/9/8/medline SP - 391 EP - 7 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 34 IS - 3 N2 - The effect of cycloamylose on the aqueous solubility of flurbiprofen was investigated. To improve the solubility and bioavailability of flurbiprofen (poor water solubility), a solid dispersion was spray dried with a solution of flurbiprofen and cycloamylose at a weight ratio of 1:1. The physicochemical properties of solid dispersions were investigated using SEM, DSC, and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with a commercial product. Cycloamylose increased solubility of flurbiprofen approximately 12-fold and dissolution of it by 2-fold. Flurbiprofen was present in an unchanged crystalline state, and cycloamylose was a solubilizing agent for flurbiprofen in this solid dispersion. Furthermore, the dispersion gave higher AUC and C(max) values compared with the commercial product, indicating that it improved the oral bioavailability of flurbiprofen in rats. Thus, the solid dispersion may be useful to deliver flurbiprofen with enhanced bioavailability without changes in crystalline structure. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/21547670/Enhanced_solubility_and_bioavailability_of_flurbiprofen_by_cycloamylose_ L2 - https://dx.doi.org/10.1007/s12272-011-0306-x DB - PRIME DP - Unbound Medicine ER -