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Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assay.
Nat Prod Res. 2011 May; 25(9):918-26.NP

Abstract

Activity-guided fractionation of the ethanolic extract of the leaves of the Polyalthia longifolia var. pendula led to the identification of quercetin (1), quercetin-3-O-β-glucopyranoside (2), kaempferol-3-O-α-rhamnopyranosyl-(1 → 6)-β-galactopyranoside (3), kaempferol-3-O-α-rhamnopyranosyl-(1 → 6)-β-glucopyranoside (4), rutin (5) and allantoin (6) as the active constituents from the butanol fraction. Compounds 2-4 are reported for the first time from this natural source. Structures of the compounds were confirmed on the basis of their 1D and 2D NMR coupled with other spectroscopic methods. All the isolated compounds and the fractions were evaluated for their antioxidant potential using the TEAC assays and it was found that the activity of the active fraction was due to quercetin (1) and its glycosides (2 and 5), with TEAC values of 4.10, 1.91 and 2.38 mM, respectively, while the kaempferol glycosides were found to be inactive. This is the first study on the antioxidant activity of this plant species.

Authors+Show Affiliations

Division of Medicinal and Process Chemistry, Central Drug Research Institute (CSIR), Uttar Pradesh, India. sashidhar123@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21547843

Citation

Sashidhara, Koneni V., et al. "Identification of the Antioxidant Principles of Polyalthia Longifolia Var. Pendula Using TEAC Assay." Natural Product Research, vol. 25, no. 9, 2011, pp. 918-26.
Sashidhara KV, Singh SP, Srivastava A, et al. Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assay. Nat Prod Res. 2011;25(9):918-26.
Sashidhara, K. V., Singh, S. P., Srivastava, A., & Puri, A. (2011). Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assay. Natural Product Research, 25(9), 918-26. https://doi.org/10.1080/14786419.2010.490214
Sashidhara KV, et al. Identification of the Antioxidant Principles of Polyalthia Longifolia Var. Pendula Using TEAC Assay. Nat Prod Res. 2011;25(9):918-26. PubMed PMID: 21547843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assay. AU - Sashidhara,Koneni V, AU - Singh,Suriya P, AU - Srivastava,Anuj, AU - Puri,Anju, PY - 2011/5/7/entrez PY - 2011/5/7/pubmed PY - 2011/7/30/medline SP - 918 EP - 26 JF - Natural product research JO - Nat Prod Res VL - 25 IS - 9 N2 - Activity-guided fractionation of the ethanolic extract of the leaves of the Polyalthia longifolia var. pendula led to the identification of quercetin (1), quercetin-3-O-β-glucopyranoside (2), kaempferol-3-O-α-rhamnopyranosyl-(1 → 6)-β-galactopyranoside (3), kaempferol-3-O-α-rhamnopyranosyl-(1 → 6)-β-glucopyranoside (4), rutin (5) and allantoin (6) as the active constituents from the butanol fraction. Compounds 2-4 are reported for the first time from this natural source. Structures of the compounds were confirmed on the basis of their 1D and 2D NMR coupled with other spectroscopic methods. All the isolated compounds and the fractions were evaluated for their antioxidant potential using the TEAC assays and it was found that the activity of the active fraction was due to quercetin (1) and its glycosides (2 and 5), with TEAC values of 4.10, 1.91 and 2.38 mM, respectively, while the kaempferol glycosides were found to be inactive. This is the first study on the antioxidant activity of this plant species. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21547843/Identification_of_the_antioxidant_principles_of_Polyalthia_longifolia_var__pendula_using_TEAC_assay_ L2 - https://www.tandfonline.com/doi/full/10.1080/14786419.2010.490214 DB - PRIME DP - Unbound Medicine ER -