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Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia.
Pediatr Blood Cancer 2012; 58(2):233-8PB

Abstract

BACKGROUND

Micronutrient deficiencies among pregnant women are widespread in low-income countries, including Egypt. Iron deficiency anemia (IDA) is the most frequent nutritional deficiency during pregnancy, with an impact on maternal and fetal morbidity and mortality. We aimed to evaluate the effect of maternal IDA and nutritional status on birth anthropometry, cord blood iron profile and breast milk micronutrients in 50 anemic (hemoglobin <11 g/dl) and 30 healthy pregnant women.

PROCEDURE

Maternal and neonatal anthropometric measures were recorded. Hemoglobin, red blood cell (RBC) indices, and indices of iron nutriture were measured in maternal and cord blood. Breast milk minerals; iron, copper, zinc, calcium, and magnesium were assessed.

RESULTS

Hemoglobin, RBC indices, and iron profile showed significant differences in the neonates born to anemic mothers compared to controls, particularly in moderate to severe anemia and linear correlations with maternal hemoglobin, iron, and ferritin levels were found (P < 0.01). Anthropometric measurements of anemic mothers and their neonates were positively correlated (P < 0.05). Breast milk micronutrients were significantly reduced in all anemic mothers showing significant relations with maternal serum iron (P < 0.01).

CONCLUSIONS

Maternal IDA wields a significant influence on maternal and fetal nutritional status. IDA during pregnancy adversely affects both cord blood iron and breast milk mineral status, particularly in moderate to severe anemia and concurrent micronutrient deficiencies occur in maternal IDA. Further investigations including larger population of pregnant women with severe anemia are needed to verify the nutritional interrelation between maternal anemia and breast milk mineral status.

Authors+Show Affiliations

Pediatrics Department, Ain Shams University, Cairo, Egypt.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21548016

Citation

El-Farrash, Rania Ali, et al. "Cord Blood Iron Profile and Breast Milk Micronutrients in Maternal Iron Deficiency Anemia." Pediatric Blood & Cancer, vol. 58, no. 2, 2012, pp. 233-8.
El-Farrash RA, Ismail EA, Nada AS. Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatr Blood Cancer. 2012;58(2):233-8.
El-Farrash, R. A., Ismail, E. A., & Nada, A. S. (2012). Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatric Blood & Cancer, 58(2), pp. 233-8. doi:10.1002/pbc.23184.
El-Farrash RA, Ismail EA, Nada AS. Cord Blood Iron Profile and Breast Milk Micronutrients in Maternal Iron Deficiency Anemia. Pediatr Blood Cancer. 2012;58(2):233-8. PubMed PMID: 21548016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. AU - El-Farrash,Rania Ali, AU - Ismail,Eman Abdel Rahman, AU - Nada,Ahmed Shafik, Y1 - 2011/05/05/ PY - 2010/12/27/received PY - 2011/04/07/accepted PY - 2011/5/7/entrez PY - 2011/5/7/pubmed PY - 2012/2/1/medline SP - 233 EP - 8 JF - Pediatric blood & cancer JO - Pediatr Blood Cancer VL - 58 IS - 2 N2 - BACKGROUND: Micronutrient deficiencies among pregnant women are widespread in low-income countries, including Egypt. Iron deficiency anemia (IDA) is the most frequent nutritional deficiency during pregnancy, with an impact on maternal and fetal morbidity and mortality. We aimed to evaluate the effect of maternal IDA and nutritional status on birth anthropometry, cord blood iron profile and breast milk micronutrients in 50 anemic (hemoglobin <11 g/dl) and 30 healthy pregnant women. PROCEDURE: Maternal and neonatal anthropometric measures were recorded. Hemoglobin, red blood cell (RBC) indices, and indices of iron nutriture were measured in maternal and cord blood. Breast milk minerals; iron, copper, zinc, calcium, and magnesium were assessed. RESULTS: Hemoglobin, RBC indices, and iron profile showed significant differences in the neonates born to anemic mothers compared to controls, particularly in moderate to severe anemia and linear correlations with maternal hemoglobin, iron, and ferritin levels were found (P < 0.01). Anthropometric measurements of anemic mothers and their neonates were positively correlated (P < 0.05). Breast milk micronutrients were significantly reduced in all anemic mothers showing significant relations with maternal serum iron (P < 0.01). CONCLUSIONS: Maternal IDA wields a significant influence on maternal and fetal nutritional status. IDA during pregnancy adversely affects both cord blood iron and breast milk mineral status, particularly in moderate to severe anemia and concurrent micronutrient deficiencies occur in maternal IDA. Further investigations including larger population of pregnant women with severe anemia are needed to verify the nutritional interrelation between maternal anemia and breast milk mineral status. SN - 1545-5017 UR - https://www.unboundmedicine.com/medline/citation/21548016/Cord_blood_iron_profile_and_breast_milk_micronutrients_in_maternal_iron_deficiency_anemia_ L2 - https://doi.org/10.1002/pbc.23184 DB - PRIME DP - Unbound Medicine ER -