Tags

Type your tag names separated by a space and hit enter

Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats.
Eur J Pharmacol. 2011 Jul 01; 661(1-3):118-23.EJ

Abstract

Accumulative evidences have showed that some coumarin derivatives have significantly anti-inflammatory effects. To investigate the potential anti-inflammatory effect of compound IMMLG5521, a novel coumarin derivative, carrageenan-induced pleurisy model in rats was employed. The results showed that IMMLG5521 (5, 10 and 20 mg/kg) exhibited anti-inflammatory effects, reducing pleural exudate formation, decreasing total number of inflammation cells and polymorphonuclear leukocytes infiltration, attenuating histological injury and reducing TNF-α, IL-1β, MIP-2 and IL-8 release. Further investigation revealed that the compound may exert its anti-inflammatory effect via inhibiting nuclear translocation of NF-кB in inflammatory cells collected from pleural exudates. Taken together, the present results suggested that IMMLG5521 inhibited acute inflammation in carrageenan-induced pleurisy model that could be, in part, related to a reduction of release of inflammatory factors, another part may be related to an inhibition of NF-кB activation.

Authors+Show Affiliations

Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21549112

Citation

Li, Zhi-Peng, et al. "Effect of Compound IMMLG5521, a Novel Coumarin Derivative, On Carrageenan-induced Pleurisy in Rats." European Journal of Pharmacology, vol. 661, no. 1-3, 2011, pp. 118-23.
Li ZP, Hu JF, Sun MN, et al. Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats. Eur J Pharmacol. 2011;661(1-3):118-23.
Li, Z. P., Hu, J. F., Sun, M. N., Ji, H. J., Zhao, M., Wu, D. H., Li, G. Y., Liu, G., & Chen, N. H. (2011). Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats. European Journal of Pharmacology, 661(1-3), 118-23. https://doi.org/10.1016/j.ejphar.2011.04.024
Li ZP, et al. Effect of Compound IMMLG5521, a Novel Coumarin Derivative, On Carrageenan-induced Pleurisy in Rats. Eur J Pharmacol. 2011 Jul 1;661(1-3):118-23. PubMed PMID: 21549112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of compound IMMLG5521, a novel coumarin derivative, on carrageenan-induced pleurisy in rats. AU - Li,Zhi-Peng, AU - Hu,Jin-Feng, AU - Sun,Ming-Na, AU - Ji,Hai-Jie, AU - Zhao,Ming, AU - Wu,Dong-Hui, AU - Li,Guang-Yan, AU - Liu,Gang, AU - Chen,Nai-Hong, Y1 - 2011/04/27/ PY - 2011/01/10/received PY - 2011/03/15/revised PY - 2011/04/05/accepted PY - 2011/5/10/entrez PY - 2011/5/10/pubmed PY - 2011/9/21/medline SP - 118 EP - 23 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 661 IS - 1-3 N2 - Accumulative evidences have showed that some coumarin derivatives have significantly anti-inflammatory effects. To investigate the potential anti-inflammatory effect of compound IMMLG5521, a novel coumarin derivative, carrageenan-induced pleurisy model in rats was employed. The results showed that IMMLG5521 (5, 10 and 20 mg/kg) exhibited anti-inflammatory effects, reducing pleural exudate formation, decreasing total number of inflammation cells and polymorphonuclear leukocytes infiltration, attenuating histological injury and reducing TNF-α, IL-1β, MIP-2 and IL-8 release. Further investigation revealed that the compound may exert its anti-inflammatory effect via inhibiting nuclear translocation of NF-кB in inflammatory cells collected from pleural exudates. Taken together, the present results suggested that IMMLG5521 inhibited acute inflammation in carrageenan-induced pleurisy model that could be, in part, related to a reduction of release of inflammatory factors, another part may be related to an inhibition of NF-кB activation. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/21549112/Effect_of_compound_IMMLG5521_a_novel_coumarin_derivative_on_carrageenan_induced_pleurisy_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(11)00414-6 DB - PRIME DP - Unbound Medicine ER -