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Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women.
Bone. 2011 Aug; 49(2):194-201.BONE

Abstract

BACKGROUND

In women with anorexia nervosa, elevated fasting peptide YY (PYY) is associated with decreased bone mineral density (BMD). Prior research from our lab has demonstrated that fasting total PYY concentrations are elevated in exercising women with amenorrhea compared to ovulatory exercising women.

PURPOSE

The purpose of this study was to assess the association between fasting total PYY, average monthly estrogen exposure and BMD in non-obese premenopausal exercising women.

METHODS

Daily urine samples were collected and assessed for metabolites of estrone 1-glucuronide (E1G) and pregnandiol glucuronide (PdG) for at least one menstrual cycle if ovulatory or a 28-day monitoring period if amenorrheic. Fasting serum samples were pooled over the measurement period and analyzed for total PYY and leptin. BMD and body composition were assessed by dual-energy X-ray absorptiometry. Multiple regression analyses were performed to determine whether measures of body composition, estrogen status, exercise minutes, leptin and PYY explained a significant amount of the variance in BMD at multiple sites.

RESULTS

Premenopausal exercising women aged 23.8±0.9years with a mean BMI of 21.2±0.4kg/m(2) exercised 346±48min/week and had a peak oxygen uptake of 49.1±1.8mL/kg/min. Thirty-nine percent (17/44) of the women had amenorrhea. Fasting total PYY concentrations were negatively associated with total body BMD (p=0.033) and total hip BMD (p=0.043). Mean E1G concentrations were positively associated with total body BMD (p=0.033) and lumbar spine (L2-L4) BMD (p=0.047). The proportion of variance in lumbar spine (L2-L4) BMD explained by body weight and E1G cycle mean was 16.4% (R(2)=0.204, p=0.012). The proportion of variance in hip BMD explained by PYY cycle mean was 8.6% (R(2)=0.109, p=0.033). The proportion of variance in total body BMD explained by body weight and E1G cycle mean was 21.9% (R(2)=0.257, p=0.003).

CONCLUSION

PYY, mean E1G and body weight are associated with BMD in premenopausal exercising women. Thus, elevated PYY and suppressed estrogen concentrations are associated with, and could be directly contributing to, low BMD in exercising women with amenorrhea, despite regular physical activity.

Authors+Show Affiliations

Women's Health and Exercise Laboratory, Department of Kinesiology, Penn State University, University Park, PA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21549231

Citation

Scheid, J L., et al. "Estrogen and Peptide YY Are Associated With Bone Mineral Density in Premenopausal Exercising Women." Bone, vol. 49, no. 2, 2011, pp. 194-201.
Scheid JL, Toombs RJ, Ducher G, et al. Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women. Bone. 2011;49(2):194-201.
Scheid, J. L., Toombs, R. J., Ducher, G., Gibbs, J. C., Williams, N. I., & De Souza, M. J. (2011). Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women. Bone, 49(2), 194-201. https://doi.org/10.1016/j.bone.2011.04.011
Scheid JL, et al. Estrogen and Peptide YY Are Associated With Bone Mineral Density in Premenopausal Exercising Women. Bone. 2011;49(2):194-201. PubMed PMID: 21549231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women. AU - Scheid,J L, AU - Toombs,R J, AU - Ducher,G, AU - Gibbs,J C, AU - Williams,N I, AU - De Souza,M J, Y1 - 2011/04/28/ PY - 2010/10/08/received PY - 2011/03/11/revised PY - 2011/04/14/accepted PY - 2011/5/10/entrez PY - 2011/5/10/pubmed PY - 2011/12/15/medline SP - 194 EP - 201 JF - Bone JO - Bone VL - 49 IS - 2 N2 - BACKGROUND: In women with anorexia nervosa, elevated fasting peptide YY (PYY) is associated with decreased bone mineral density (BMD). Prior research from our lab has demonstrated that fasting total PYY concentrations are elevated in exercising women with amenorrhea compared to ovulatory exercising women. PURPOSE: The purpose of this study was to assess the association between fasting total PYY, average monthly estrogen exposure and BMD in non-obese premenopausal exercising women. METHODS: Daily urine samples were collected and assessed for metabolites of estrone 1-glucuronide (E1G) and pregnandiol glucuronide (PdG) for at least one menstrual cycle if ovulatory or a 28-day monitoring period if amenorrheic. Fasting serum samples were pooled over the measurement period and analyzed for total PYY and leptin. BMD and body composition were assessed by dual-energy X-ray absorptiometry. Multiple regression analyses were performed to determine whether measures of body composition, estrogen status, exercise minutes, leptin and PYY explained a significant amount of the variance in BMD at multiple sites. RESULTS: Premenopausal exercising women aged 23.8±0.9years with a mean BMI of 21.2±0.4kg/m(2) exercised 346±48min/week and had a peak oxygen uptake of 49.1±1.8mL/kg/min. Thirty-nine percent (17/44) of the women had amenorrhea. Fasting total PYY concentrations were negatively associated with total body BMD (p=0.033) and total hip BMD (p=0.043). Mean E1G concentrations were positively associated with total body BMD (p=0.033) and lumbar spine (L2-L4) BMD (p=0.047). The proportion of variance in lumbar spine (L2-L4) BMD explained by body weight and E1G cycle mean was 16.4% (R(2)=0.204, p=0.012). The proportion of variance in hip BMD explained by PYY cycle mean was 8.6% (R(2)=0.109, p=0.033). The proportion of variance in total body BMD explained by body weight and E1G cycle mean was 21.9% (R(2)=0.257, p=0.003). CONCLUSION: PYY, mean E1G and body weight are associated with BMD in premenopausal exercising women. Thus, elevated PYY and suppressed estrogen concentrations are associated with, and could be directly contributing to, low BMD in exercising women with amenorrhea, despite regular physical activity. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/21549231/Estrogen_and_peptide_YY_are_associated_with_bone_mineral_density_in_premenopausal_exercising_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(11)00933-1 DB - PRIME DP - Unbound Medicine ER -