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A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk.
Ann Oncol 2012; 23(2):287-97AO

Abstract

BACKGROUND

In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data.

PATIENTS AND METHODS

We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models.

RESULTS

The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day.

CONCLUSIONS

This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.

Authors+Show Affiliations

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21551004

Citation

Tramacere, I, et al. "A Meta-analysis On Alcohol Drinking and Esophageal and Gastric Cardia Adenocarcinoma Risk." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 2, 2012, pp. 287-97.
Tramacere I, Pelucchi C, Bagnardi V, et al. A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Ann Oncol. 2012;23(2):287-97.
Tramacere, I., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., Islami, F., ... Negri, E. (2012). A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(2), pp. 287-97. doi:10.1093/annonc/mdr136.
Tramacere I, et al. A Meta-analysis On Alcohol Drinking and Esophageal and Gastric Cardia Adenocarcinoma Risk. Ann Oncol. 2012;23(2):287-97. PubMed PMID: 21551004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. AU - Tramacere,I, AU - Pelucchi,C, AU - Bagnardi,V, AU - Rota,M, AU - Scotti,L, AU - Islami,F, AU - Corrao,G, AU - Boffetta,P, AU - La Vecchia,C, AU - Negri,E, Y1 - 2011/05/05/ PY - 2011/5/10/entrez PY - 2011/5/10/pubmed PY - 2012/5/23/medline SP - 287 EP - 97 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 2 N2 - BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21551004/A_meta_analysis_on_alcohol_drinking_and_esophageal_and_gastric_cardia_adenocarcinoma_risk_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr136 DB - PRIME DP - Unbound Medicine ER -