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A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk.
Ann Oncol 2012; 23(2):287-97AO

Abstract

BACKGROUND

In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data.

PATIENTS AND METHODS

We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models.

RESULTS

The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day.

CONCLUSIONS

This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.

Authors+Show Affiliations

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21551004

Citation

Tramacere, I, et al. "A Meta-analysis On Alcohol Drinking and Esophageal and Gastric Cardia Adenocarcinoma Risk." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 2, 2012, pp. 287-97.
Tramacere I, Pelucchi C, Bagnardi V, et al. A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Ann Oncol. 2012;23(2):287-97.
Tramacere, I., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., Islami, F., ... Negri, E. (2012). A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(2), pp. 287-97. doi:10.1093/annonc/mdr136.
Tramacere I, et al. A Meta-analysis On Alcohol Drinking and Esophageal and Gastric Cardia Adenocarcinoma Risk. Ann Oncol. 2012;23(2):287-97. PubMed PMID: 21551004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. AU - Tramacere,I, AU - Pelucchi,C, AU - Bagnardi,V, AU - Rota,M, AU - Scotti,L, AU - Islami,F, AU - Corrao,G, AU - Boffetta,P, AU - La Vecchia,C, AU - Negri,E, Y1 - 2011/05/05/ PY - 2011/5/10/entrez PY - 2011/5/10/pubmed PY - 2012/5/23/medline SP - 287 EP - 97 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 2 N2 - BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (≤ 1 drink per day), 0.90 for moderate (1 to < 4 drinks per day), and 1.16 for heavy (≥ 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21551004/A_meta_analysis_on_alcohol_drinking_and_esophageal_and_gastric_cardia_adenocarcinoma_risk_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr136 DB - PRIME DP - Unbound Medicine ER -