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Possible involvement of the endocannabinoid system in memory modulation effect of general anesthetics.

Abstract

Amnesia is a fundamental component of a proper general anesthetic. The mechanism of anesthetic-induced amnesia remains poorly understood. Nowadays, intraoperative awareness and postoperative cognitive dysfunction are two distressing problems receiving increased attention by clinicians, patients and the general public. Extensive evidence indicates that general anesthetics cause amnesia by working on hippocampus and basolateral amygdala (BLA). Recently, evidence from studies in experimental animals has shown that either intra-hippocampus or intra-BLA injection of endogenous cannabinoid receptor 1 (CB1) drugs result in significant changes of cognitive function. In addition, several general anesthetics (i.e. propofol, etomidate and isoflurane) have been reported to interact with the endocannabinoid system. However, there are few studies about whether the CB1 receptor system is involved in anesthetic-induced amnesia. We hypothesize that the CB1 receptor activity in hippocampus and BLA might be regulated by general anesthetics. Once the involvement of the endocannabinoid system in anesthetic-induced amnesia is proved, it will provide a new way to prevent and treat post-traumatic stress disorder caused by intraoperative awareness and postoperative cognitive dysfunction in the future.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Anesthesiology, Fudan University Cancer Hospital, Shanghai, People's Republic of China.

    ,

    Source

    Medical hypotheses 77:2 2011 Aug pg 246-9

    MeSH

    Amnesia
    Amygdala
    Anesthetics, General
    Cannabinoid Receptor Modulators
    Endocannabinoids
    Hippocampus
    Humans
    Models, Neurological
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21555187

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Possible involvement of the endocannabinoid system in memory modulation effect of general anesthetics. AU - Ren,Yu, AU - Xu,Ya-Jun, AU - Tan,Zhi-Ming, Y1 - 2011/05/08/ PY - 2011/01/10/received PY - 2011/04/06/revised PY - 2011/04/11/accepted PY - 2011/5/11/entrez PY - 2011/5/11/pubmed PY - 2011/12/13/medline SP - 246 EP - 9 JF - Medical hypotheses JO - Med. Hypotheses VL - 77 IS - 2 N2 - Amnesia is a fundamental component of a proper general anesthetic. The mechanism of anesthetic-induced amnesia remains poorly understood. Nowadays, intraoperative awareness and postoperative cognitive dysfunction are two distressing problems receiving increased attention by clinicians, patients and the general public. Extensive evidence indicates that general anesthetics cause amnesia by working on hippocampus and basolateral amygdala (BLA). Recently, evidence from studies in experimental animals has shown that either intra-hippocampus or intra-BLA injection of endogenous cannabinoid receptor 1 (CB1) drugs result in significant changes of cognitive function. In addition, several general anesthetics (i.e. propofol, etomidate and isoflurane) have been reported to interact with the endocannabinoid system. However, there are few studies about whether the CB1 receptor system is involved in anesthetic-induced amnesia. We hypothesize that the CB1 receptor activity in hippocampus and BLA might be regulated by general anesthetics. Once the involvement of the endocannabinoid system in anesthetic-induced amnesia is proved, it will provide a new way to prevent and treat post-traumatic stress disorder caused by intraoperative awareness and postoperative cognitive dysfunction in the future. SN - 1532-2777 UR - https://www.unboundmedicine.com/medline/citation/21555187/abstract/Possible_involvement_of_the_endocannabinoid_system_in_memory_modulation_effect_of_general_anesthetics_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(11)00185-X DB - PRIME DP - Unbound Medicine ER -