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Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats.
Horm Metab Res. 2011 Jun; 43(7):452-7.HM

Abstract

Thyroid hormones regulate energy balance and act on adipokines. However, while it is unclear what the effects are of calorie restriction and high doses of triiodothyronine (T(3)) on adipokines in obesity, thyroid hormones are illicitly administered in isolation or in association with a hypocaloric diet as an obesity treatment. The present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats. Male Wistar rats received a hypercaloric diet for 20 weeks followed by calorie restriction for 8 weeks. The animals were then randomly divided into 3 groups: calorie restriction (OR), OR with 5 μg of T(3)/100 g BW (RS1), and OR with 25 μg of T(3)/100 g BW (RS2) for 2 weeks. Blood and adipose tissue samples were collected for biochemical, hormonal, and gene expression analyses. Serum concentrations of leptin (OR: 3.7±0.6, RS1: 3.8±1, RS2 0.2±0.07 ng/dl) and resistin (OR: 2.5±0.6, RS1: 2.5±0.5, RS2 1.6±0.3 ng/dl) were diminished at the higher dose, while serum adiponectin (OR: 31±7, RS1: 24±5, RS2 26±7 ng/dl) levels were lower in the low dose group. Administration of T(3) reduced leptin gene expression (OR: 0.91±0.1, RS1: 0.95±0.1, RS2 0.22±0.1) only at the higher dose, resistin expression (OR: 1.06±0.2, RS1: 1.04±0.1, RS2 0.88±0.2) was not influenced by T(3) treatment, and adiponectin expression (OR: 1.55±0.5, RS1: 0.95±0.15, RS2 0.97±0.13) was diminished independent of the T(3) dose. These results indicate that T(3), directly or indirectly, inhibits the expression of leptin and adiponectin in calorie restricted obese animals.

Authors+Show Affiliations

Department of Clinical Medicine, Botucatu School of Medicine, UNESP - University of São Paulo State, Botucatu, São Paulo, Brazil. reluvizotto@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21557150

Citation

Luvizotto, R A M., et al. "Supraphysiological Triiodothyronine Doses Diminish Leptin and Adiponectin Gene Expression, but Do Not Alter Resistin Expression in Calorie Restricted Obese Rats." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 43, no. 7, 2011, pp. 452-7.
Luvizotto RA, Síbio MT, Olímpio RM, et al. Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Horm Metab Res. 2011;43(7):452-7.
Luvizotto, R. A., Síbio, M. T., Olímpio, R. M., Nascimento, A. F., Lima-Leopoldo, A. P., Leopoldo, A. S., Padovani, C. R., Cicogna, A. C., & Nogueira, C. R. (2011). Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 43(7), 452-7. https://doi.org/10.1055/s-0031-1277187
Luvizotto RA, et al. Supraphysiological Triiodothyronine Doses Diminish Leptin and Adiponectin Gene Expression, but Do Not Alter Resistin Expression in Calorie Restricted Obese Rats. Horm Metab Res. 2011;43(7):452-7. PubMed PMID: 21557150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supraphysiological triiodothyronine doses diminish leptin and adiponectin gene expression, but do not alter resistin expression in calorie restricted obese rats. AU - Luvizotto,R A M, AU - Síbio,M T, AU - Olímpio,R M C, AU - Nascimento,A F, AU - Lima-Leopoldo,A P, AU - Leopoldo,A S, AU - Padovani,C R, AU - Cicogna,A C, AU - Nogueira,C R, Y1 - 2011/05/09/ PY - 2011/5/11/entrez PY - 2011/5/11/pubmed PY - 2011/9/29/medline SP - 452 EP - 7 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 43 IS - 7 N2 - Thyroid hormones regulate energy balance and act on adipokines. However, while it is unclear what the effects are of calorie restriction and high doses of triiodothyronine (T(3)) on adipokines in obesity, thyroid hormones are illicitly administered in isolation or in association with a hypocaloric diet as an obesity treatment. The present study determined the effect of T(3) on serum concentrations and gene expression of the adipokines leptin, resistin, and adiponectin in calorie-restricted obese rats. Male Wistar rats received a hypercaloric diet for 20 weeks followed by calorie restriction for 8 weeks. The animals were then randomly divided into 3 groups: calorie restriction (OR), OR with 5 μg of T(3)/100 g BW (RS1), and OR with 25 μg of T(3)/100 g BW (RS2) for 2 weeks. Blood and adipose tissue samples were collected for biochemical, hormonal, and gene expression analyses. Serum concentrations of leptin (OR: 3.7±0.6, RS1: 3.8±1, RS2 0.2±0.07 ng/dl) and resistin (OR: 2.5±0.6, RS1: 2.5±0.5, RS2 1.6±0.3 ng/dl) were diminished at the higher dose, while serum adiponectin (OR: 31±7, RS1: 24±5, RS2 26±7 ng/dl) levels were lower in the low dose group. Administration of T(3) reduced leptin gene expression (OR: 0.91±0.1, RS1: 0.95±0.1, RS2 0.22±0.1) only at the higher dose, resistin expression (OR: 1.06±0.2, RS1: 1.04±0.1, RS2 0.88±0.2) was not influenced by T(3) treatment, and adiponectin expression (OR: 1.55±0.5, RS1: 0.95±0.15, RS2 0.97±0.13) was diminished independent of the T(3) dose. These results indicate that T(3), directly or indirectly, inhibits the expression of leptin and adiponectin in calorie restricted obese animals. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/21557150/Supraphysiological_triiodothyronine_doses_diminish_leptin_and_adiponectin_gene_expression_but_do_not_alter_resistin_expression_in_calorie_restricted_obese_rats_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1277187 DB - PRIME DP - Unbound Medicine ER -