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Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring.
Eur J Clin Nutr. 2011 Aug; 65(8):937-43.EJ

Abstract

BACKGROUND/OBJECTIVES

The potential immune functions related to the damages induced by oxygen-free radicals suggest that antioxidants may have a role in the development of allergies. The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children.

SUBJECTS/METHODS

This study was on the basis of the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with 5-year follow-up. Complete information on maternal food frequency questionnaire data and ISAAC (International Study of Asthma and Allergies in Childhood)-based allergic outcomes were available for 2441 children. Cox proportional regression and logistic regression were used for the analyses.

RESULTS

Maternal intake of any of the antioxidants was not significantly associated with the risk of asthma, rhinitis or eczema in the offspring, except for dietary intake of magnesium, which was independently associated with protection against eczema (OR 0.78; 95% CI 0.62-0.97).

CONCLUSION

Maternal intake of dietary magnesium during pregnancy may protect against the risk of eczema in the offspring. We did not confirm previous observations concerning other antioxidants. This may be due to the variable amount of antioxidant intake across studies and also indicative of the hypothesis that there may be a critical time window in pregnancy during which antioxidants might modify the risk of allergies in the offspring.

Authors+Show Affiliations

School of Health Sciences, University of Tampere, Tampere, Finland. bright.nwaru@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21559033

Citation

Nwaru, B I., et al. "Intake of Antioxidants During Pregnancy and the Risk of Allergies and Asthma in the Offspring." European Journal of Clinical Nutrition, vol. 65, no. 8, 2011, pp. 937-43.
Nwaru BI, Erkkola M, Ahonen S, et al. Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring. Eur J Clin Nutr. 2011;65(8):937-43.
Nwaru, B. I., Erkkola, M., Ahonen, S., Kaila, M., Kronberg-Kippilä, C., Ilonen, J., Simell, O., Knip, M., Veijola, R., & Virtanen, S. M. (2011). Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring. European Journal of Clinical Nutrition, 65(8), 937-43. https://doi.org/10.1038/ejcn.2011.67
Nwaru BI, et al. Intake of Antioxidants During Pregnancy and the Risk of Allergies and Asthma in the Offspring. Eur J Clin Nutr. 2011;65(8):937-43. PubMed PMID: 21559033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring. AU - Nwaru,B I, AU - Erkkola,M, AU - Ahonen,S, AU - Kaila,M, AU - Kronberg-Kippilä,C, AU - Ilonen,J, AU - Simell,O, AU - Knip,M, AU - Veijola,R, AU - Virtanen,S M, Y1 - 2011/05/11/ PY - 2011/5/12/entrez PY - 2011/5/12/pubmed PY - 2011/12/16/medline SP - 937 EP - 43 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 65 IS - 8 N2 - BACKGROUND/OBJECTIVES: The potential immune functions related to the damages induced by oxygen-free radicals suggest that antioxidants may have a role in the development of allergies. The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children. SUBJECTS/METHODS: This study was on the basis of the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with 5-year follow-up. Complete information on maternal food frequency questionnaire data and ISAAC (International Study of Asthma and Allergies in Childhood)-based allergic outcomes were available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. RESULTS: Maternal intake of any of the antioxidants was not significantly associated with the risk of asthma, rhinitis or eczema in the offspring, except for dietary intake of magnesium, which was independently associated with protection against eczema (OR 0.78; 95% CI 0.62-0.97). CONCLUSION: Maternal intake of dietary magnesium during pregnancy may protect against the risk of eczema in the offspring. We did not confirm previous observations concerning other antioxidants. This may be due to the variable amount of antioxidant intake across studies and also indicative of the hypothesis that there may be a critical time window in pregnancy during which antioxidants might modify the risk of allergies in the offspring. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21559033/Intake_of_antioxidants_during_pregnancy_and_the_risk_of_allergies_and_asthma_in_the_offspring_ L2 - http://dx.doi.org/10.1038/ejcn.2011.67 DB - PRIME DP - Unbound Medicine ER -