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Laryngeal reinnervation using ansa cervicalis for thyroid surgery-related unilateral vocal fold paralysis: a long-term outcome analysis of 237 cases.
PLoS One. 2011 Apr 29; 6(4):e19128.Plos

Abstract

OBJECTIVE

To evaluate the long-term efficacy of delayed laryngeal reinnervation using the main branch of the ansa cervicalis in treatment of unilateral vocal fold paralysis (UVFP) caused by thyroid surgery.

SUMMARY OF BACKGROUND DATA

UVFP remains a serious complication of thyroid surgery. Up to now, a completely satisfactory surgical treatment of UVFP has been elusive.

METHODS

From Jan. 1996 to Jan. 2008, a total of 237 UVFP patients who underwent ansa cervicalis main branch-to-recurrent laryngeal nerve (RLN) anastomosis were enrolled as UVFP group; another 237 age- and gender-matched normal subjects served as control group. Videostroboscopy, vocal function assessment (acoustic analysis, perceptual evaluation and maximum phonation time), and electromyography were performed preoperatively and postoperatively. The mean follow-up period was 5.2±2.7 years, ranging from 2 to 12 years.

RESULTS

Analysis of videostroboscopic findings indicated that the glottic closure, vocal fold edge, vocal fold position, phase symmetry and regularity were significantly improved in the UVFP group (P<0.001, postoperative vs. preoperative). The postoperative parameters of vocal function were also significantly improved in the UVFP group (P<0.001) and showed no statistical differences compared to the control group (P>0.05, respectively). Postoperative laryngeal electromyography confirmed successful reinnervation of laryngeal muscle.

CONCLUSIONS

Delayed laryngeal reinnervation with the main branch of ansa cervicalis is a feasible and effective approach for treatment of thyroid surgery-related UVFP; it can restore the physiological laryngeal phonatory function to the normal or a nearly normal voice quality.

Authors+Show Affiliations

Department of Otorhinolaryngology-Head and Neck Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21559458

Citation

Wang, Wei, et al. "Laryngeal Reinnervation Using Ansa Cervicalis for Thyroid Surgery-related Unilateral Vocal Fold Paralysis: a Long-term Outcome Analysis of 237 Cases." PloS One, vol. 6, no. 4, 2011, pp. e19128.
Wang W, Chen D, Chen S, et al. Laryngeal reinnervation using ansa cervicalis for thyroid surgery-related unilateral vocal fold paralysis: a long-term outcome analysis of 237 cases. PLoS One. 2011;6(4):e19128.
Wang, W., Chen, D., Chen, S., Li, D., Li, M., Xia, S., & Zheng, H. (2011). Laryngeal reinnervation using ansa cervicalis for thyroid surgery-related unilateral vocal fold paralysis: a long-term outcome analysis of 237 cases. PloS One, 6(4), e19128. https://doi.org/10.1371/journal.pone.0019128
Wang W, et al. Laryngeal Reinnervation Using Ansa Cervicalis for Thyroid Surgery-related Unilateral Vocal Fold Paralysis: a Long-term Outcome Analysis of 237 Cases. PLoS One. 2011 Apr 29;6(4):e19128. PubMed PMID: 21559458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laryngeal reinnervation using ansa cervicalis for thyroid surgery-related unilateral vocal fold paralysis: a long-term outcome analysis of 237 cases. AU - Wang,Wei, AU - Chen,Donghui, AU - Chen,Shicai, AU - Li,Ding, AU - Li,Meng, AU - Xia,Siwen, AU - Zheng,Hongliang, Y1 - 2011/04/29/ PY - 2011/01/05/received PY - 2011/03/16/accepted PY - 2011/5/12/entrez PY - 2011/5/12/pubmed PY - 2011/12/13/medline SP - e19128 EP - e19128 JF - PloS one JO - PLoS One VL - 6 IS - 4 N2 - OBJECTIVE: To evaluate the long-term efficacy of delayed laryngeal reinnervation using the main branch of the ansa cervicalis in treatment of unilateral vocal fold paralysis (UVFP) caused by thyroid surgery. SUMMARY OF BACKGROUND DATA: UVFP remains a serious complication of thyroid surgery. Up to now, a completely satisfactory surgical treatment of UVFP has been elusive. METHODS: From Jan. 1996 to Jan. 2008, a total of 237 UVFP patients who underwent ansa cervicalis main branch-to-recurrent laryngeal nerve (RLN) anastomosis were enrolled as UVFP group; another 237 age- and gender-matched normal subjects served as control group. Videostroboscopy, vocal function assessment (acoustic analysis, perceptual evaluation and maximum phonation time), and electromyography were performed preoperatively and postoperatively. The mean follow-up period was 5.2±2.7 years, ranging from 2 to 12 years. RESULTS: Analysis of videostroboscopic findings indicated that the glottic closure, vocal fold edge, vocal fold position, phase symmetry and regularity were significantly improved in the UVFP group (P<0.001, postoperative vs. preoperative). The postoperative parameters of vocal function were also significantly improved in the UVFP group (P<0.001) and showed no statistical differences compared to the control group (P>0.05, respectively). Postoperative laryngeal electromyography confirmed successful reinnervation of laryngeal muscle. CONCLUSIONS: Delayed laryngeal reinnervation with the main branch of ansa cervicalis is a feasible and effective approach for treatment of thyroid surgery-related UVFP; it can restore the physiological laryngeal phonatory function to the normal or a nearly normal voice quality. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/21559458/Laryngeal_reinnervation_using_ansa_cervicalis_for_thyroid_surgery_related_unilateral_vocal_fold_paralysis:_a_long_term_outcome_analysis_of_237_cases_ DB - PRIME DP - Unbound Medicine ER -