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Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome.
Am J Clin Nutr. 2011 Jul; 94(1):262-9.AJ

Abstract

BACKGROUND

Adiponectin gene expression is modulated by peroxisome proliferator-activated receptor γ, which is a transcription factor activated by unsaturated fatty acids.

OBJECTIVE

We investigated the effect of the interaction between variants at the ADIPOQ gene locus, age, sex, body mass index (BMI), ethnicity, and the replacement of dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) or carbohydrates on serum adiponectin concentrations.

DESIGN

The RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) study is a parallel-design, randomized controlled trial. Serum adiponectin concentrations were measured after a 4-wk high-SFA (HS) diet and a 24-wk intervention with reference (HS), high-MUFA (HM), and low-fat (LF) diets. Single nucleotide polymorphisms at the ADIPOQ locus -11391 G/A (rs17300539), -10066 G/A (rs182052), -7734 A/C (rs16861209), and +276 G/T (rs1501299) were genotyped in 448 participants.

RESULTS

In white Europeans, +276 T was associated with higher serum adiponectin concentrations (n = 340; P = 0.006) and -10066 A was associated with lower serum adiponectin concentrations (n = 360; P = 0.03), after adjustment for age, BMI, and sex. After the HM diet, -10066 G/G subjects showed a 3.8% increase (95% CI: -0.1%, 7.7%) and G/A+A/A subjects a 2.6% decrease (95% CI: -5.6%, 0.4%) in serum adiponectin (P = 0.006 for difference after adjustment for the change in BMI, age, and sex). In -10066 G/G homozygotes, serum adiponectin increased with age after the HM diet and decreased after the LF diet.

CONCLUSION

In white -10066 G/G homozygotes, an HM diet may help to increase adiponectin concentrations with advancing age. This trial was registered at clinicaltrials.gov as ISRCTN29111298.

Authors+Show Affiliations

Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21562092

Citation

AlSaleh, Aseel, et al. "Single Nucleotide Polymorphisms at the ADIPOQ Gene Locus Interact With Age and Dietary Intake of Fat to Determine Serum Adiponectin in Subjects at Risk of the Metabolic Syndrome." The American Journal of Clinical Nutrition, vol. 94, no. 1, 2011, pp. 262-9.
AlSaleh A, O'Dell SD, Frost GS, et al. Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome. Am J Clin Nutr. 2011;94(1):262-9.
AlSaleh, A., O'Dell, S. D., Frost, G. S., Griffin, B. A., Lovegrove, J. A., Jebb, S. A., & Sanders, T. A. (2011). Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome. The American Journal of Clinical Nutrition, 94(1), 262-9. https://doi.org/10.3945/ajcn.111.014209
AlSaleh A, et al. Single Nucleotide Polymorphisms at the ADIPOQ Gene Locus Interact With Age and Dietary Intake of Fat to Determine Serum Adiponectin in Subjects at Risk of the Metabolic Syndrome. Am J Clin Nutr. 2011;94(1):262-9. PubMed PMID: 21562092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome. AU - AlSaleh,Aseel, AU - O'Dell,Sandra D, AU - Frost,Gary S, AU - Griffin,Bruce A, AU - Lovegrove,Julie A, AU - Jebb,Susan A, AU - Sanders,Thomas A B, AU - ,, Y1 - 2011/05/11/ PY - 2011/5/13/entrez PY - 2011/5/13/pubmed PY - 2011/8/25/medline SP - 262 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 94 IS - 1 N2 - BACKGROUND: Adiponectin gene expression is modulated by peroxisome proliferator-activated receptor γ, which is a transcription factor activated by unsaturated fatty acids. OBJECTIVE: We investigated the effect of the interaction between variants at the ADIPOQ gene locus, age, sex, body mass index (BMI), ethnicity, and the replacement of dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) or carbohydrates on serum adiponectin concentrations. DESIGN: The RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) study is a parallel-design, randomized controlled trial. Serum adiponectin concentrations were measured after a 4-wk high-SFA (HS) diet and a 24-wk intervention with reference (HS), high-MUFA (HM), and low-fat (LF) diets. Single nucleotide polymorphisms at the ADIPOQ locus -11391 G/A (rs17300539), -10066 G/A (rs182052), -7734 A/C (rs16861209), and +276 G/T (rs1501299) were genotyped in 448 participants. RESULTS: In white Europeans, +276 T was associated with higher serum adiponectin concentrations (n = 340; P = 0.006) and -10066 A was associated with lower serum adiponectin concentrations (n = 360; P = 0.03), after adjustment for age, BMI, and sex. After the HM diet, -10066 G/G subjects showed a 3.8% increase (95% CI: -0.1%, 7.7%) and G/A+A/A subjects a 2.6% decrease (95% CI: -5.6%, 0.4%) in serum adiponectin (P = 0.006 for difference after adjustment for the change in BMI, age, and sex). In -10066 G/G homozygotes, serum adiponectin increased with age after the HM diet and decreased after the LF diet. CONCLUSION: In white -10066 G/G homozygotes, an HM diet may help to increase adiponectin concentrations with advancing age. This trial was registered at clinicaltrials.gov as ISRCTN29111298. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21562092/Single_nucleotide_polymorphisms_at_the_ADIPOQ_gene_locus_interact_with_age_and_dietary_intake_of_fat_to_determine_serum_adiponectin_in_subjects_at_risk_of_the_metabolic_syndrome_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.014209 DB - PRIME DP - Unbound Medicine ER -