Tags

Type your tag names separated by a space and hit enter

A novel tool for the prediction of tablet sticking during high speed compaction.
Pharm Dev Technol. 2012 Nov-Dec; 17(6):747-54.PD

Abstract

During tableting, capping is a problem of cohesion while sticking is a problem of adhesion. Sticking is a multi-composite problem; causes are either material or machine related. Nowadays, detecting such a problem is a pre-requisite in the early stages of development. The aim of our study was to investigate sticking by radial die-wall pressure monitoring guided by compaction simulation. This was done by using the highly sticking drug; Mefenamic acid (MA) at different drug loadings with different fillers compacted at different pressures and speeds. By increasing MA loading, we found that viscoelastic fillers showed high residual radial pressure after compaction while plastic/brittle fillers showed high radial pressure during compaction, p < 0.05. Visually, plastic/brittle fillers showed greater tendencies for adhesion to punches than viscoelastic fillers while the later showed higher tendencies for adhesion to the die-wall. This was confirmed by higher values of axial stress transmission for plastic/brittle than viscoelastic fillers (higher punch surface/powder interaction), and higher residual die-wall and ejection forces for viscoelastic than plastic/brittle fillers, p < 0.05. Take-off force was not a useful tool to estimate sticking due to cohesive failure of the compacts. Radial die-wall pressure monitoring is suggested as a robust tool to predict sticking.

Links

Publisher Full Text

Authors+Show Affiliations

Abdel-Hamid S
Industrial Pharmacy Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. sameh.abdel-hamid@unibas.ch
Betz G
No affiliation info available

MeSH

Compressive StrengthDrug CompoundingDrug IndustryExcipientsMefenamic AcidParticle SizePorosityPowdersPressureSurface PropertiesTabletsTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21563986

Citation

Abdel-Hamid, Sameh, and Gabriele Betz. "A Novel Tool for the Prediction of Tablet Sticking During High Speed Compaction." Pharmaceutical Development and Technology, vol. 17, no. 6, 2012, pp. 747-54.
Abdel-Hamid S, Betz G. A novel tool for the prediction of tablet sticking during high speed compaction. Pharm Dev Technol. 2012;17(6):747-54.
Abdel-Hamid, S., & Betz, G. (2012). A novel tool for the prediction of tablet sticking during high speed compaction. Pharmaceutical Development and Technology, 17(6), 747-54. https://doi.org/10.3109/10837450.2011.580761
Abdel-Hamid S, Betz G. A Novel Tool for the Prediction of Tablet Sticking During High Speed Compaction. Pharm Dev Technol. 2012 Nov-Dec;17(6):747-54. PubMed PMID: 21563986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel tool for the prediction of tablet sticking during high speed compaction. AU - Abdel-Hamid,Sameh, AU - Betz,Gabriele, Y1 - 2011/05/13/ PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2013/5/23/medline SP - 747 EP - 54 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 17 IS - 6 N2 - During tableting, capping is a problem of cohesion while sticking is a problem of adhesion. Sticking is a multi-composite problem; causes are either material or machine related. Nowadays, detecting such a problem is a pre-requisite in the early stages of development. The aim of our study was to investigate sticking by radial die-wall pressure monitoring guided by compaction simulation. This was done by using the highly sticking drug; Mefenamic acid (MA) at different drug loadings with different fillers compacted at different pressures and speeds. By increasing MA loading, we found that viscoelastic fillers showed high residual radial pressure after compaction while plastic/brittle fillers showed high radial pressure during compaction, p < 0.05. Visually, plastic/brittle fillers showed greater tendencies for adhesion to punches than viscoelastic fillers while the later showed higher tendencies for adhesion to the die-wall. This was confirmed by higher values of axial stress transmission for plastic/brittle than viscoelastic fillers (higher punch surface/powder interaction), and higher residual die-wall and ejection forces for viscoelastic than plastic/brittle fillers, p < 0.05. Take-off force was not a useful tool to estimate sticking due to cohesive failure of the compacts. Radial die-wall pressure monitoring is suggested as a robust tool to predict sticking. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/21563986/A_novel_tool_for_the_prediction_of_tablet_sticking_during_high_speed_compaction_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2011.580761 DB - PRIME DP - Unbound Medicine ER -