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The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis.
Br J Dermatol. 2011 Aug; 165(2):329-34.BJ

Abstract

BACKGROUND

The emollient aqueous cream BP is frequently used for the treatment of atopic dermatitis (AD), yet it is associated with a high rate of adverse cutaneous reactions. It contains the harsh anionic surfactant sodium lauryl sulphate, a known negative environmental factor associated with the exacerbation of AD.

OBJECTIVES

To investigate the effect of aqueous cream BP on stratum corneum (SC) integrity and skin barrier function in volunteers with a predisposition to a defective skin barrier.

METHODS

Thirteen volunteers with a previous history of AD (no symptoms for 6 months) applied aqueous cream BP twice daily to the volar side of one forearm for 4 weeks. The other forearm was left untreated as a control. Permeability barrier function and SC integrity were determined before and after treatment by measuring transepidermal water loss (TEWL) in conjunction with tape-stripping. For comparison, 13 volunteers with current AD were recruited for assessment, without treatment, of SC integrity and skin barrier function at unaffected sites.

RESULTS

Topical application of aqueous cream BP resulted in significant elevation of baseline TEWL and a concomitant decrease in SC integrity. Measurements made after no treatment in volunteers with current AD, at unaffected sites, suggest that application of aqueous cream BP negatively affects the skin barrier towards the damaged state associated with onset of flares of the disease.

CONCLUSIONS

Aqueous cream BP used as a leave-on emollient caused severe damage to the skin barrier in volunteers with a previous history of AD. Aqueous cream BP should not be used as a leave-on emollient in patients with AD.

Authors+Show Affiliations

Academic Unit of Dermatology Research, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK. s.danby@sheffield.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21564067

Citation

Danby, S G., et al. "The Effect of Aqueous Cream BP On the Skin Barrier in Volunteers With a Previous History of Atopic Dermatitis." The British Journal of Dermatology, vol. 165, no. 2, 2011, pp. 329-34.
Danby SG, Al-Enezi T, Sultan A, et al. The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis. Br J Dermatol. 2011;165(2):329-34.
Danby, S. G., Al-Enezi, T., Sultan, A., Chittock, J., Kennedy, K., & Cork, M. J. (2011). The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis. The British Journal of Dermatology, 165(2), 329-34. https://doi.org/10.1111/j.1365-2133.2011.10395.x
Danby SG, et al. The Effect of Aqueous Cream BP On the Skin Barrier in Volunteers With a Previous History of Atopic Dermatitis. Br J Dermatol. 2011;165(2):329-34. PubMed PMID: 21564067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis. AU - Danby,S G, AU - Al-Enezi,T, AU - Sultan,A, AU - Chittock,J, AU - Kennedy,K, AU - Cork,M J, Y1 - 2011/07/11/ PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/10/18/medline SP - 329 EP - 34 JF - The British journal of dermatology JO - Br J Dermatol VL - 165 IS - 2 N2 - BACKGROUND: The emollient aqueous cream BP is frequently used for the treatment of atopic dermatitis (AD), yet it is associated with a high rate of adverse cutaneous reactions. It contains the harsh anionic surfactant sodium lauryl sulphate, a known negative environmental factor associated with the exacerbation of AD. OBJECTIVES: To investigate the effect of aqueous cream BP on stratum corneum (SC) integrity and skin barrier function in volunteers with a predisposition to a defective skin barrier. METHODS: Thirteen volunteers with a previous history of AD (no symptoms for 6 months) applied aqueous cream BP twice daily to the volar side of one forearm for 4 weeks. The other forearm was left untreated as a control. Permeability barrier function and SC integrity were determined before and after treatment by measuring transepidermal water loss (TEWL) in conjunction with tape-stripping. For comparison, 13 volunteers with current AD were recruited for assessment, without treatment, of SC integrity and skin barrier function at unaffected sites. RESULTS: Topical application of aqueous cream BP resulted in significant elevation of baseline TEWL and a concomitant decrease in SC integrity. Measurements made after no treatment in volunteers with current AD, at unaffected sites, suggest that application of aqueous cream BP negatively affects the skin barrier towards the damaged state associated with onset of flares of the disease. CONCLUSIONS: Aqueous cream BP used as a leave-on emollient caused severe damage to the skin barrier in volunteers with a previous history of AD. Aqueous cream BP should not be used as a leave-on emollient in patients with AD. SN - 1365-2133 UR - https://www.unboundmedicine.com/medline/citation/21564067/The_effect_of_aqueous_cream_BP_on_the_skin_barrier_in_volunteers_with_a_previous_history_of_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1365-2133.2011.10395.x DB - PRIME DP - Unbound Medicine ER -