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Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer.
Colorectal Dis. 2011 Jun; 13(6):e145-53.CD

Abstract

AIM

The study aimed to assess the diagnostic yield of a colonoscopy screening programme in first-degree relatives of colorectal cancer (CRC) patients and to identify factors associated with advanced neoplasia.

METHOD

We conducted a cross-sectional study. Individual characteristics, family trees and colonoscopy findings of asymptomatic first-degree relatives of CRC patients were collected. The findings were classified into cancer (invasive carcinoma and/or non-invasive high-grade neoplasia), high-risk adenomas (≥ 10 mm and/or a villous component) and low-risk adenomas (tubular < 10 mm). The dependent variable was the presence of advanced neoplasia, defined as cancer and/or high-risk adenoma.

RESULTS

Two hundred and sixty-three relatives (147 females), 50.0 ± 11.5 (range, 25-75) years of age, agreed to participate out of a total of 618 who were invited (acceptance rate 42.5%). Index cases were diagnosed at 63.8 ± 12.4 (range, 37-88) years of age. The closest familial relationship was parent/offspring in 168 (63.9%) participants and sibling in 95 (36.1%) participants; 14.8% had three or more relatives with CRC/cancer associated with Lynch syndrome, and two or more affected generations were identified in 24.0%. Advanced neoplasia was found in 56 (21.3%) participants. Of these, invasive cancer, non-invasive high-grade neoplasia and high-risk adenomas were detected in five (1.9%), six (2.3%) and 45 (17.1%) participants, respectively. Low-risk adenomas were detected in 20 (7.6%) participants. Male sex (odds ratio, 2.59; P = 0.003) and sibling relationship (odds ratio, 2.74; P = 0.001) were independently associated with advanced neoplasia.

CONCLUSION

We detected advanced neoplasia in a considerable number of participants. Our data support colonoscopy screening in first-degree relatives of patients with CRC at an earlier age than in the medium-risk population. Male sex and sibling relationship were predictors of advanced neoplasia.

Authors+Show Affiliations

Department of Gastroenterology, Alto Guadalquivir Hospital, Andújar-Jaén, Spain. jjpuente@ephag.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21564467

Citation

Puente Gutiérrez, J J., et al. "Effectiveness of a Colonoscopic Screening Programme in First-degree Relatives of Patients With Colorectal Cancer." Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, vol. 13, no. 6, 2011, pp. e145-53.
Puente Gutiérrez JJ, Marín Moreno MA, Domínguez Jiménez JL, et al. Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer. Colorectal Dis. 2011;13(6):e145-53.
Puente Gutiérrez, J. J., Marín Moreno, M. A., Domínguez Jiménez, J. L., Bernal Blanco, E., & Díaz Iglesias, J. M. (2011). Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer. Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland, 13(6), e145-53. https://doi.org/10.1111/j.1463-1318.2011.02577.x
Puente Gutiérrez JJ, et al. Effectiveness of a Colonoscopic Screening Programme in First-degree Relatives of Patients With Colorectal Cancer. Colorectal Dis. 2011;13(6):e145-53. PubMed PMID: 21564467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer. AU - Puente Gutiérrez,J J, AU - Marín Moreno,M A, AU - Domínguez Jiménez,J L, AU - Bernal Blanco,E, AU - Díaz Iglesias,J M, PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/10/25/medline SP - e145 EP - 53 JF - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland JO - Colorectal Dis VL - 13 IS - 6 N2 - AIM: The study aimed to assess the diagnostic yield of a colonoscopy screening programme in first-degree relatives of colorectal cancer (CRC) patients and to identify factors associated with advanced neoplasia. METHOD: We conducted a cross-sectional study. Individual characteristics, family trees and colonoscopy findings of asymptomatic first-degree relatives of CRC patients were collected. The findings were classified into cancer (invasive carcinoma and/or non-invasive high-grade neoplasia), high-risk adenomas (≥ 10 mm and/or a villous component) and low-risk adenomas (tubular < 10 mm). The dependent variable was the presence of advanced neoplasia, defined as cancer and/or high-risk adenoma. RESULTS: Two hundred and sixty-three relatives (147 females), 50.0 ± 11.5 (range, 25-75) years of age, agreed to participate out of a total of 618 who were invited (acceptance rate 42.5%). Index cases were diagnosed at 63.8 ± 12.4 (range, 37-88) years of age. The closest familial relationship was parent/offspring in 168 (63.9%) participants and sibling in 95 (36.1%) participants; 14.8% had three or more relatives with CRC/cancer associated with Lynch syndrome, and two or more affected generations were identified in 24.0%. Advanced neoplasia was found in 56 (21.3%) participants. Of these, invasive cancer, non-invasive high-grade neoplasia and high-risk adenomas were detected in five (1.9%), six (2.3%) and 45 (17.1%) participants, respectively. Low-risk adenomas were detected in 20 (7.6%) participants. Male sex (odds ratio, 2.59; P = 0.003) and sibling relationship (odds ratio, 2.74; P = 0.001) were independently associated with advanced neoplasia. CONCLUSION: We detected advanced neoplasia in a considerable number of participants. Our data support colonoscopy screening in first-degree relatives of patients with CRC at an earlier age than in the medium-risk population. Male sex and sibling relationship were predictors of advanced neoplasia. SN - 1463-1318 UR - https://www.unboundmedicine.com/medline/citation/21564467/Effectiveness_of_a_colonoscopic_screening_programme_in_first_degree_relatives_of_patients_with_colorectal_cancer_ L2 - https://doi.org/10.1111/j.1463-1318.2011.02577.x DB - PRIME DP - Unbound Medicine ER -