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TNFRSF1A coding variants in multiple sclerosis.
J Neuroimmunol 2011; 235(1-2):110-2JN

Abstract

Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS). In a study population of 967 MS patients and 1022 controls, we replicate association [P=5×10⁻⁴, 3% in patients versus 1% in controls, OR=2.26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed.

Authors+Show Affiliations

Laboratory for Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Herestraat 49 Bus 1022, 3000 Leuven, Belgium. an.goris@med.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21565411

Citation

Goris, An, et al. "TNFRSF1A Coding Variants in Multiple Sclerosis." Journal of Neuroimmunology, vol. 235, no. 1-2, 2011, pp. 110-2.
Goris A, Fockaert N, Cosemans L, et al. TNFRSF1A coding variants in multiple sclerosis. J Neuroimmunol. 2011;235(1-2):110-2.
Goris, A., Fockaert, N., Cosemans, L., Clysters, K., Nagels, G., Boonen, S., ... Dubois, B. (2011). TNFRSF1A coding variants in multiple sclerosis. Journal of Neuroimmunology, 235(1-2), pp. 110-2. doi:10.1016/j.jneuroim.2011.04.005.
Goris A, et al. TNFRSF1A Coding Variants in Multiple Sclerosis. J Neuroimmunol. 2011;235(1-2):110-2. PubMed PMID: 21565411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TNFRSF1A coding variants in multiple sclerosis. AU - Goris,An, AU - Fockaert,Niels, AU - Cosemans,Leentje, AU - Clysters,Katleen, AU - Nagels,Guy, AU - Boonen,Steven, AU - Thijs,Vincent, AU - Robberecht,Wim, AU - Dubois,Bénédicte, Y1 - 2011/05/11/ PY - 2011/03/23/received PY - 2011/04/15/accepted PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/8/9/medline SP - 110 EP - 2 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 235 IS - 1-2 N2 - Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS). In a study population of 967 MS patients and 1022 controls, we replicate association [P=5×10⁻⁴, 3% in patients versus 1% in controls, OR=2.26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/21565411/TNFRSF1A_coding_variants_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(11)00102-0 DB - PRIME DP - Unbound Medicine ER -