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TNFRSF1A coding variants in multiple sclerosis.

Abstract

Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS). In a study population of 967 MS patients and 1022 controls, we replicate association [P=5×10⁻⁴, 3% in patients versus 1% in controls, OR=2.26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed.

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  • Authors+Show Affiliations

    ,

    Laboratory for Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Herestraat 49 Bus 1022, 3000 Leuven, Belgium. an.goris@med.kuleuven.be

    , , , , , , ,

    Source

    Journal of neuroimmunology 235:1-2 2011 Jun pg 110-2

    MeSH

    Adult
    Amino Acid Substitution
    Diagnosis, Differential
    Familial Mediterranean Fever
    Genetic Variation
    Humans
    Male
    Multiple Sclerosis
    Open Reading Frames
    Receptors, Tumor Necrosis Factor, Type I
    Risk Factors
    Syndrome
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21565411

    Citation

    Goris, An, et al. "TNFRSF1A Coding Variants in Multiple Sclerosis." Journal of Neuroimmunology, vol. 235, no. 1-2, 2011, pp. 110-2.
    Goris A, Fockaert N, Cosemans L, et al. TNFRSF1A coding variants in multiple sclerosis. J Neuroimmunol. 2011;235(1-2):110-2.
    Goris, A., Fockaert, N., Cosemans, L., Clysters, K., Nagels, G., Boonen, S., ... Dubois, B. (2011). TNFRSF1A coding variants in multiple sclerosis. Journal of Neuroimmunology, 235(1-2), pp. 110-2. doi:10.1016/j.jneuroim.2011.04.005.
    Goris A, et al. TNFRSF1A Coding Variants in Multiple Sclerosis. J Neuroimmunol. 2011;235(1-2):110-2. PubMed PMID: 21565411.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - TNFRSF1A coding variants in multiple sclerosis. AU - Goris,An, AU - Fockaert,Niels, AU - Cosemans,Leentje, AU - Clysters,Katleen, AU - Nagels,Guy, AU - Boonen,Steven, AU - Thijs,Vincent, AU - Robberecht,Wim, AU - Dubois,Bénédicte, Y1 - 2011/05/11/ PY - 2011/03/23/received PY - 2011/04/15/accepted PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/8/9/medline SP - 110 EP - 2 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 235 IS - 1-2 N2 - Patients with the autoinflammatory disease Tumour Necrosis Factor receptor-associated periodic syndrome (TRAPS) who suffer from demyelinating disease have been described, and one of the milder TRAPS mutations (R92Q in the TNFRSF1A gene) has been suggested as a risk factor for multiple sclerosis (MS). In a study population of 967 MS patients and 1022 controls, we replicate association [P=5×10⁻⁴, 3% in patients versus 1% in controls, OR=2.26 (95% CI 1.41-3.61)], which appears independent of an established common risk variant in the same gene. No other non-synonymous variants in the same allele frequency range influencing risk of MS were observed. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/21565411/TNFRSF1A_coding_variants_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(11)00102-0 DB - PRIME DP - Unbound Medicine ER -