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FKBP51-a selective modulator of glucocorticoid and androgen sensitivity.
Curr Opin Pharmacol. 2011 Aug; 11(4):332-7.CO

Abstract

FK506-binding protein 51 (FKBP51) is gaining increased recognition for its essential roles in cell biology. Originally discovered as a component of steroid receptor complexes, it is now known to regulate a diverse set of transcription factors, enzymes and structural proteins. Its cellular properties suggest numerous possible functions for FKBP51 in physiology, and the best clue to its potential importance may be the following: FKBP51 is a glucocorticoid-induced negative regulator of the glucocorticoid receptor. Thus, FKBP51 is intricately involved in regulation of the most pleiotropic hormone known to biology. In contrast to glucocorticoid receptor, FKBP51 is a positive regulator of the androgen receptor, suggesting that it functions as a reciprocal modulator of glucocorticoid-mediated and androgen-mediated physiology. In this work, we evaluate this hypothesis by examining recent cellular and physiological evidence.

Authors+Show Affiliations

Center for Diabetes and Endocrine Research, Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

21565552

Citation

Stechschulte, Lance A., and Edwin R. Sanchez. "FKBP51-a Selective Modulator of Glucocorticoid and Androgen Sensitivity." Current Opinion in Pharmacology, vol. 11, no. 4, 2011, pp. 332-7.
Stechschulte LA, Sanchez ER. FKBP51-a selective modulator of glucocorticoid and androgen sensitivity. Curr Opin Pharmacol. 2011;11(4):332-7.
Stechschulte, L. A., & Sanchez, E. R. (2011). FKBP51-a selective modulator of glucocorticoid and androgen sensitivity. Current Opinion in Pharmacology, 11(4), 332-7. https://doi.org/10.1016/j.coph.2011.04.012
Stechschulte LA, Sanchez ER. FKBP51-a Selective Modulator of Glucocorticoid and Androgen Sensitivity. Curr Opin Pharmacol. 2011;11(4):332-7. PubMed PMID: 21565552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FKBP51-a selective modulator of glucocorticoid and androgen sensitivity. AU - Stechschulte,Lance A, AU - Sanchez,Edwin R, Y1 - 2011/05/11/ PY - 2011/04/07/received PY - 2011/04/19/revised PY - 2011/04/20/accepted PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/12/14/medline SP - 332 EP - 7 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 11 IS - 4 N2 - FK506-binding protein 51 (FKBP51) is gaining increased recognition for its essential roles in cell biology. Originally discovered as a component of steroid receptor complexes, it is now known to regulate a diverse set of transcription factors, enzymes and structural proteins. Its cellular properties suggest numerous possible functions for FKBP51 in physiology, and the best clue to its potential importance may be the following: FKBP51 is a glucocorticoid-induced negative regulator of the glucocorticoid receptor. Thus, FKBP51 is intricately involved in regulation of the most pleiotropic hormone known to biology. In contrast to glucocorticoid receptor, FKBP51 is a positive regulator of the androgen receptor, suggesting that it functions as a reciprocal modulator of glucocorticoid-mediated and androgen-mediated physiology. In this work, we evaluate this hypothesis by examining recent cellular and physiological evidence. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/21565552/FKBP51_a_selective_modulator_of_glucocorticoid_and_androgen_sensitivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(11)00064-6 DB - PRIME DP - Unbound Medicine ER -