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Mammographic characteristics and vacuum-assisted breast biopsy (VABB) of non-palpable breast lesions.
Acta Radiol. 2011 Jul 01; 52(6):602-7.AR

Abstract

BACKGROUND

The new imaging technology made available today allows for an early detection of small subclinical breast lesions which frequently call for guided presurgical micro-histology.

PURPOSE

To evaluate the relationship between vacuum-assisted breast biopsy (VABB) histopathological diagnoses and mammographic findings in non-palpable breast lesions.

MATERIAL AND METHODS

The breast lesions of 1393 women who had received consecutive screening mammograms between 2001 and 2007 were assessed by VABB. The mammographic breast lesions, classified according to the Breast Imaging Reporting and Data System (BI-RADS), were subjected to VABB only if rated as highly suspicious (2%), suspicious (64.5%) for malignancy, or probably benign (33.5%).

RESULTS

VABB findings included 981 (70.5%) probably benign lesions, 407 (29.2%) suspicious/malignant lesions, and five (0.3%) cases which were considered as inappropriate for diagnostic purposes. At histology, 10.2% of the suspicious/malignant lesions were classified as proliferative lesions, 11.1% as ductal carcinoma in situ (DCIS), and 8% as invasive ductal carcinoma (IDC). The positive predictive value (PPV) of BI-RADS assessment categories 3, 4 and 5 was 4.1%, 25.3% and 75%, respectively. The occurrence of obscured or spiculated masses was found to exhibit the highest PPV for malignancy (12.5% in BI-RADS 3 and 63% in BI-RADS 4), followed by microcalcifications which showed a malignancy rate of 6.4% in BI-RADS 3, and 20% in BI-RADS 4.

CONCLUSION

VABB turns out to be effective in the assessment of many malignant and benign preclinical tumour lesions thus allowing for a significant reduction of the number of surgical biopsies.

Authors+Show Affiliations

Women's Department, National Cancer Institute, Bari, Italy. ventrel@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21565889

Citation

Ventrella, Vincenzo, et al. "Mammographic Characteristics and Vacuum-assisted Breast Biopsy (VABB) of Non-palpable Breast Lesions." Acta Radiologica (Stockholm, Sweden : 1987), vol. 52, no. 6, 2011, pp. 602-7.
Ventrella V, Tufaro A, Zito FA, et al. Mammographic characteristics and vacuum-assisted breast biopsy (VABB) of non-palpable breast lesions. Acta Radiol. 2011;52(6):602-7.
Ventrella, V., Tufaro, A., Zito, F. A., Addante, M., Stea, B., Dentamaro, R., D'Amico, C., & Paradiso, A. (2011). Mammographic characteristics and vacuum-assisted breast biopsy (VABB) of non-palpable breast lesions. Acta Radiologica (Stockholm, Sweden : 1987), 52(6), 602-7. https://doi.org/10.1258/ar.2011.100319
Ventrella V, et al. Mammographic Characteristics and Vacuum-assisted Breast Biopsy (VABB) of Non-palpable Breast Lesions. Acta Radiol. 2011 Jul 1;52(6):602-7. PubMed PMID: 21565889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mammographic characteristics and vacuum-assisted breast biopsy (VABB) of non-palpable breast lesions. AU - Ventrella,Vincenzo, AU - Tufaro,Antonio, AU - Zito,Francesco A, AU - Addante,Maria, AU - Stea,Baldassarre, AU - Dentamaro,Rosalba, AU - D'Amico,Cosimo, AU - Paradiso,Angelo, Y1 - 2011/05/12/ PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/9/23/medline SP - 602 EP - 7 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 52 IS - 6 N2 - BACKGROUND: The new imaging technology made available today allows for an early detection of small subclinical breast lesions which frequently call for guided presurgical micro-histology. PURPOSE: To evaluate the relationship between vacuum-assisted breast biopsy (VABB) histopathological diagnoses and mammographic findings in non-palpable breast lesions. MATERIAL AND METHODS: The breast lesions of 1393 women who had received consecutive screening mammograms between 2001 and 2007 were assessed by VABB. The mammographic breast lesions, classified according to the Breast Imaging Reporting and Data System (BI-RADS), were subjected to VABB only if rated as highly suspicious (2%), suspicious (64.5%) for malignancy, or probably benign (33.5%). RESULTS: VABB findings included 981 (70.5%) probably benign lesions, 407 (29.2%) suspicious/malignant lesions, and five (0.3%) cases which were considered as inappropriate for diagnostic purposes. At histology, 10.2% of the suspicious/malignant lesions were classified as proliferative lesions, 11.1% as ductal carcinoma in situ (DCIS), and 8% as invasive ductal carcinoma (IDC). The positive predictive value (PPV) of BI-RADS assessment categories 3, 4 and 5 was 4.1%, 25.3% and 75%, respectively. The occurrence of obscured or spiculated masses was found to exhibit the highest PPV for malignancy (12.5% in BI-RADS 3 and 63% in BI-RADS 4), followed by microcalcifications which showed a malignancy rate of 6.4% in BI-RADS 3, and 20% in BI-RADS 4. CONCLUSION: VABB turns out to be effective in the assessment of many malignant and benign preclinical tumour lesions thus allowing for a significant reduction of the number of surgical biopsies. SN - 1600-0455 UR - https://www.unboundmedicine.com/medline/citation/21565889/Mammographic_characteristics_and_vacuum_assisted_breast_biopsy__VABB__of_non_palpable_breast_lesions_ L2 - https://journals.sagepub.com/doi/10.1258/ar.2011.100319?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -