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The effects of widespread methadone treatment on the molecular epidemiology of hepatitis C virus infection among injection drug users in Hong Kong.
J Med Virol. 2011 Jul; 83(7):1187-94.JM

Abstract

The distribution of HCV genotypes among injection drug users in Hong Kong was assessed in context of methadone treatment availability. Three time periods were defined by the year of initiating injection-on or before 1980, 1981-1994, and 1995-2006-with methadone becoming widely available since the second period. Of the 273 HCV RNA-positive cases, the most prevalent subtype was HCV 6a (52.4%), followed by HCV 1b (38.5%). The new variants of HCV subtypes 6e and 6h were detected. Both subtypes 1b and 6a were prevalent among older injectors, while subtype 3a was more common in young injectors and those initiating injection recently during the third time period. Age (P < 0.05) and recent injection frequency (P < 0.01) were independently associated with HCV 6a infection. Subtype 1b was predominant in the first period, whereas 6a was more common in the second and third. Subtype 1b sequences appeared to have originated at two positions on the phylogenetic tree, while 6a showed a more disperse distribution suggestive of multiple introductions. Phylogenetic analysis on the NS5B region did not reveal specific clustering of any subtype/genotype. Overall, there was no suggestion of outbreaks of HCV. The extensive use of methadone may have protected Hong Kong from the emergence of HCV clusters among injection drug users.

Authors+Show Affiliations

Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21567422

Citation

Chan, Denise P C., et al. "The Effects of Widespread Methadone Treatment On the Molecular Epidemiology of Hepatitis C Virus Infection Among Injection Drug Users in Hong Kong." Journal of Medical Virology, vol. 83, no. 7, 2011, pp. 1187-94.
Chan DP, Lee SS, Lee KC. The effects of widespread methadone treatment on the molecular epidemiology of hepatitis C virus infection among injection drug users in Hong Kong. J Med Virol. 2011;83(7):1187-94.
Chan, D. P., Lee, S. S., & Lee, K. C. (2011). The effects of widespread methadone treatment on the molecular epidemiology of hepatitis C virus infection among injection drug users in Hong Kong. Journal of Medical Virology, 83(7), 1187-94. https://doi.org/10.1002/jmv.22099
Chan DP, Lee SS, Lee KC. The Effects of Widespread Methadone Treatment On the Molecular Epidemiology of Hepatitis C Virus Infection Among Injection Drug Users in Hong Kong. J Med Virol. 2011;83(7):1187-94. PubMed PMID: 21567422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of widespread methadone treatment on the molecular epidemiology of hepatitis C virus infection among injection drug users in Hong Kong. AU - Chan,Denise P C, AU - Lee,Shui Shan, AU - Lee,Krystal C K, PY - 2011/5/14/entrez PY - 2011/5/14/pubmed PY - 2011/9/14/medline SP - 1187 EP - 94 JF - Journal of medical virology JO - J Med Virol VL - 83 IS - 7 N2 - The distribution of HCV genotypes among injection drug users in Hong Kong was assessed in context of methadone treatment availability. Three time periods were defined by the year of initiating injection-on or before 1980, 1981-1994, and 1995-2006-with methadone becoming widely available since the second period. Of the 273 HCV RNA-positive cases, the most prevalent subtype was HCV 6a (52.4%), followed by HCV 1b (38.5%). The new variants of HCV subtypes 6e and 6h were detected. Both subtypes 1b and 6a were prevalent among older injectors, while subtype 3a was more common in young injectors and those initiating injection recently during the third time period. Age (P < 0.05) and recent injection frequency (P < 0.01) were independently associated with HCV 6a infection. Subtype 1b was predominant in the first period, whereas 6a was more common in the second and third. Subtype 1b sequences appeared to have originated at two positions on the phylogenetic tree, while 6a showed a more disperse distribution suggestive of multiple introductions. Phylogenetic analysis on the NS5B region did not reveal specific clustering of any subtype/genotype. Overall, there was no suggestion of outbreaks of HCV. The extensive use of methadone may have protected Hong Kong from the emergence of HCV clusters among injection drug users. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/21567422/The_effects_of_widespread_methadone_treatment_on_the_molecular_epidemiology_of_hepatitis_C_virus_infection_among_injection_drug_users_in_Hong_Kong_ L2 - https://doi.org/10.1002/jmv.22099 DB - PRIME DP - Unbound Medicine ER -