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Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells.
Food Chem Toxicol 2011; 49(8):1745-52FC

Abstract

Fucoidan, a sulfated polysaccharide extracted from brown seaweed, displays a wide variety of internal biological activities; however, the cellular and molecular mechanisms underlying fucoidan's anti-inflammatory activity remain poorly understood. In this study, we investigated the inhibitory effects of fucoidan on production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators in BV2 microglia. Our data indicated that fucoidan treatment significantly inhibited excessive production of nitric oxide (NO) and prostaglandin E₂ (PGE₂) in LPS-stimulated BV2 microglia. It also attenuated expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, monocyte chemoattractant protein-1 (MCP-1), and pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor (TNF)-α. Moreover, fucoidan exhibited anti-inflammatory properties by suppression of nuclear factor-kappa B (NF-κB) activation and down-regulation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and AKT pathways. These finding suggest that fucoidan may offer substantial therapeutic potential for treatment of neurodegenerative diseases that are accompanied by microglial activation.

Authors+Show Affiliations

Department of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21570441

Citation

Park, Hye Young, et al. "Anti-inflammatory Effects of Fucoidan Through Inhibition of NF-κB, MAPK and Akt Activation in Lipopolysaccharide-induced BV2 Microglia Cells." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 49, no. 8, 2011, pp. 1745-52.
Park HY, Han MH, Park C, et al. Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. Food Chem Toxicol. 2011;49(8):1745-52.
Park, H. Y., Han, M. H., Park, C., Jin, C. Y., Kim, G. Y., Choi, I. W., ... Choi, Y. H. (2011). Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 49(8), pp. 1745-52. doi:10.1016/j.fct.2011.04.020.
Park HY, et al. Anti-inflammatory Effects of Fucoidan Through Inhibition of NF-κB, MAPK and Akt Activation in Lipopolysaccharide-induced BV2 Microglia Cells. Food Chem Toxicol. 2011;49(8):1745-52. PubMed PMID: 21570441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory effects of fucoidan through inhibition of NF-κB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. AU - Park,Hye Young, AU - Han,Min Ho, AU - Park,Cheol, AU - Jin,Cheng-Yun, AU - Kim,Gi-Young, AU - Choi,Il-Whan, AU - Kim,Nam Deuk, AU - Nam,Taek-Jeong, AU - Kwon,Taeg Kyu, AU - Choi,Yung Hyun, Y1 - 2011/05/04/ PY - 2010/11/15/received PY - 2011/03/26/revised PY - 2011/04/19/accepted PY - 2011/5/17/entrez PY - 2011/5/17/pubmed PY - 2011/9/29/medline SP - 1745 EP - 52 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 49 IS - 8 N2 - Fucoidan, a sulfated polysaccharide extracted from brown seaweed, displays a wide variety of internal biological activities; however, the cellular and molecular mechanisms underlying fucoidan's anti-inflammatory activity remain poorly understood. In this study, we investigated the inhibitory effects of fucoidan on production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators in BV2 microglia. Our data indicated that fucoidan treatment significantly inhibited excessive production of nitric oxide (NO) and prostaglandin E₂ (PGE₂) in LPS-stimulated BV2 microglia. It also attenuated expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, monocyte chemoattractant protein-1 (MCP-1), and pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor (TNF)-α. Moreover, fucoidan exhibited anti-inflammatory properties by suppression of nuclear factor-kappa B (NF-κB) activation and down-regulation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and AKT pathways. These finding suggest that fucoidan may offer substantial therapeutic potential for treatment of neurodegenerative diseases that are accompanied by microglial activation. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/21570441/Anti_inflammatory_effects_of_fucoidan_through_inhibition_of_NF_κB_MAPK_and_Akt_activation_in_lipopolysaccharide_induced_BV2_microglia_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00168-2 DB - PRIME DP - Unbound Medicine ER -