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Synthesis and antimicrobial evaluation of new benzofuran derivatives.
Eur J Med Chem. 2011 Aug; 46(8):3526-30.EJ

Abstract

Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S.aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC(80) = 0.39-3.12 μg/mL), which were better than the control drugs.

Authors+Show Affiliations

School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd., Shanghai 200240, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21570749

Citation

Jiang, Xizhen, et al. "Synthesis and Antimicrobial Evaluation of New Benzofuran Derivatives." European Journal of Medicinal Chemistry, vol. 46, no. 8, 2011, pp. 3526-30.
Jiang X, Liu W, Zhang W, et al. Synthesis and antimicrobial evaluation of new benzofuran derivatives. Eur J Med Chem. 2011;46(8):3526-30.
Jiang, X., Liu, W., Zhang, W., Jiang, F., Gao, Z., Zhuang, H., & Fu, L. (2011). Synthesis and antimicrobial evaluation of new benzofuran derivatives. European Journal of Medicinal Chemistry, 46(8), 3526-30. https://doi.org/10.1016/j.ejmech.2011.04.053
Jiang X, et al. Synthesis and Antimicrobial Evaluation of New Benzofuran Derivatives. Eur J Med Chem. 2011;46(8):3526-30. PubMed PMID: 21570749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and antimicrobial evaluation of new benzofuran derivatives. AU - Jiang,Xizhen, AU - Liu,Wenlu, AU - Zhang,Wei, AU - Jiang,Faqin, AU - Gao,Zhe, AU - Zhuang,Hao, AU - Fu,Lei, Y1 - 2011/04/28/ PY - 2010/12/06/received PY - 2011/04/20/revised PY - 2011/04/21/accepted PY - 2011/5/17/entrez PY - 2011/5/17/pubmed PY - 2011/10/1/medline SP - 3526 EP - 30 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 46 IS - 8 N2 - Thirteen compounds, based on benzofuran skeleton bearing aryl substituents at its C-3 position through methanone linker, were synthesized and screened for their antibacterial and antifungal activities against four bacteria Escherichia coli, Staphylococcus aureus, Methicillin-resistant S.aureus, Bacillus subtilis, and a fungus Candida albicans. Four hydrophobic benzofuran analogs were found to exhibit favorable antibacterial activities (MIC(80) = 0.39-3.12 μg/mL), which were better than the control drugs. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/21570749/Synthesis_and_antimicrobial_evaluation_of_new_benzofuran_derivatives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(11)00351-5 DB - PRIME DP - Unbound Medicine ER -