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Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol.
Klin Wochenschr. 1990 Jan 19; 68(2):129-35.KW

Abstract

Nociceptive activity was elicited in neurones of the thalamus by supramaximal electrical stimulation of afferent C fibres in the sural nerve of rats under urethane anesthesia. The fixed combination of vitamin B1, B6, and B12 (Neurobion) as well as of vitamin B6 administered by i.p. injection dose-dependently reduced the evoked nociceptive activity. The ED50 of Neurobion is 4.6 ml/kg (at 100 min after injection) and that of vitamin B6 is 189 mg/kg (at 90 min after injection). The minimum effective doses of Neurobion and vitamin B6 are 0.5 ml/kg and 40 mg/kg, respectively. When Neurobion or vitamin B6 were given at their minimum effective doses, and the minimum effective doses of morphine (0.025 mg/kg) or paracetamol (5 mg/kg) were injected i.v. 80 min later, i.e., when the maximum effect of higher doses of Neurobion or vitamin B6 was about to develop, no supraadditive effect developed. It is concluded that the antinociceptive effect caused by a single injection of Neurobion is largely due to vitamin B6. Vitamin B12 may contribute to this effect, whereas vitamin B1 alone exhibited only a slight effect on nociception. Moreover, it appears that Neurobion produces its antinociceptive effect after a single injection and after repeated administration during several days by different mechanisms so that the effect of analgesic agents is not enhanced following a single injection of Neurobion but may be enhanced after repeated administration of the compound.

Authors+Show Affiliations

Institut für Pharmakologie und Toxikologie der Universität des Saarlandes, Homburg/Saar.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2157085

Citation

Jurna, I, et al. "Acute Effects of Vitamin B6 and Fixed Combinations of Vitamin B1, B6 and B12 On Nociceptive Activity Evoked in the Rat Thalamus: Dose-response Relationship and Combinations With Morphine and Paracetamol." Klinische Wochenschrift, vol. 68, no. 2, 1990, pp. 129-35.
Jurna I, Carlsson KH, Kömen W, et al. Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol. Klin Wochenschr. 1990;68(2):129-35.
Jurna, I., Carlsson, K. H., Kömen, W., & Bonke, D. (1990). Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol. Klinische Wochenschrift, 68(2), 129-35.
Jurna I, et al. Acute Effects of Vitamin B6 and Fixed Combinations of Vitamin B1, B6 and B12 On Nociceptive Activity Evoked in the Rat Thalamus: Dose-response Relationship and Combinations With Morphine and Paracetamol. Klin Wochenschr. 1990 Jan 19;68(2):129-35. PubMed PMID: 2157085.
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TY - JOUR T1 - Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol. AU - Jurna,I, AU - Carlsson,K H, AU - Kömen,W, AU - Bonke,D, PY - 1990/1/19/pubmed PY - 1990/1/19/medline PY - 1990/1/19/entrez SP - 129 EP - 35 JF - Klinische Wochenschrift JO - Klin Wochenschr VL - 68 IS - 2 N2 - Nociceptive activity was elicited in neurones of the thalamus by supramaximal electrical stimulation of afferent C fibres in the sural nerve of rats under urethane anesthesia. The fixed combination of vitamin B1, B6, and B12 (Neurobion) as well as of vitamin B6 administered by i.p. injection dose-dependently reduced the evoked nociceptive activity. The ED50 of Neurobion is 4.6 ml/kg (at 100 min after injection) and that of vitamin B6 is 189 mg/kg (at 90 min after injection). The minimum effective doses of Neurobion and vitamin B6 are 0.5 ml/kg and 40 mg/kg, respectively. When Neurobion or vitamin B6 were given at their minimum effective doses, and the minimum effective doses of morphine (0.025 mg/kg) or paracetamol (5 mg/kg) were injected i.v. 80 min later, i.e., when the maximum effect of higher doses of Neurobion or vitamin B6 was about to develop, no supraadditive effect developed. It is concluded that the antinociceptive effect caused by a single injection of Neurobion is largely due to vitamin B6. Vitamin B12 may contribute to this effect, whereas vitamin B1 alone exhibited only a slight effect on nociception. Moreover, it appears that Neurobion produces its antinociceptive effect after a single injection and after repeated administration during several days by different mechanisms so that the effect of analgesic agents is not enhanced following a single injection of Neurobion but may be enhanced after repeated administration of the compound. SN - 0023-2173 UR - https://www.unboundmedicine.com/medline/citation/2157085/Acute_effects_of_vitamin_B6_and_fixed_combinations_of_vitamin_B1_B6_and_B12_on_nociceptive_activity_evoked_in_the_rat_thalamus:_dose_response_relationship_and_combinations_with_morphine_and_paracetamol_ L2 - https://medlineplus.gov/bvitamins.html DB - PRIME DP - Unbound Medicine ER -