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Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice.
Neurosci Lett. 2011 Jul 08; 498(2):133-7.NL

Abstract

The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2, 10 and 20 mg/kg) or saline at three different time points (15 min prior to training, immediately after training and 15 min before test). The results showed that higher doses of propranolol (10 and 20 mg/kg) given before the training trial impaired spatial recognition memory while those injected at other two time points did not. A detailed analysis of exploratory behavior in open-field showed that lower dose (2 mg/kg) of propranolol reduced exploratory behavior of mice. Our findings indicate that higher dose of propranolol can impair acquisition of spatial information in the Y-maze without altering locomotion, suggesting that the beta-adrenergic system may be involved in modulating memory processes at the time of learning.

Authors+Show Affiliations

State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, #32 Jiao Chang Dong Lu,Yunnan, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21571035

Citation

Sun, Huaying, et al. "Effects of Beta-adrenergic Antagonist, Propranolol On Spatial Memory and Exploratory Behavior in Mice." Neuroscience Letters, vol. 498, no. 2, 2011, pp. 133-7.
Sun H, Mao Y, Wang J, et al. Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice. Neurosci Lett. 2011;498(2):133-7.
Sun, H., Mao, Y., Wang, J., & Ma, Y. (2011). Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice. Neuroscience Letters, 498(2), 133-7. https://doi.org/10.1016/j.neulet.2011.04.076
Sun H, et al. Effects of Beta-adrenergic Antagonist, Propranolol On Spatial Memory and Exploratory Behavior in Mice. Neurosci Lett. 2011 Jul 8;498(2):133-7. PubMed PMID: 21571035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of beta-adrenergic antagonist, propranolol on spatial memory and exploratory behavior in mice. AU - Sun,Huaying, AU - Mao,Yu, AU - Wang,Jianhong, AU - Ma,Yuanye, Y1 - 2011/05/06/ PY - 2011/01/21/received PY - 2011/04/22/revised PY - 2011/04/29/accepted PY - 2011/5/17/entrez PY - 2011/5/17/pubmed PY - 2011/10/19/medline SP - 133 EP - 7 JF - Neuroscience letters JO - Neurosci Lett VL - 498 IS - 2 N2 - The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2, 10 and 20 mg/kg) or saline at three different time points (15 min prior to training, immediately after training and 15 min before test). The results showed that higher doses of propranolol (10 and 20 mg/kg) given before the training trial impaired spatial recognition memory while those injected at other two time points did not. A detailed analysis of exploratory behavior in open-field showed that lower dose (2 mg/kg) of propranolol reduced exploratory behavior of mice. Our findings indicate that higher dose of propranolol can impair acquisition of spatial information in the Y-maze without altering locomotion, suggesting that the beta-adrenergic system may be involved in modulating memory processes at the time of learning. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/21571035/Effects_of_beta_adrenergic_antagonist_propranolol_on_spatial_memory_and_exploratory_behavior_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(11)00574-X DB - PRIME DP - Unbound Medicine ER -