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Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3.
Int J STD AIDS. 2011 May; 22(5):263-72.IJ

Abstract

In addition to oncogenic 'high-risk' human papillomaviruses (HR-HPV), several co-factors are needed in cervical carcinogenesis, but it is poorly understood whether these HPV co-factors associated with incident cervical intraepithelial neoplasia (CIN) grade 1 are different from those required for progression to CIN2 and CIN3. To gain further insights into the true biological differences between CIN1, CIN2 and CIN3, we assessed HPV co-factors increasing the risk of incident CIN1, CIN2 and CIN3. Data from the New Independent States of the Former Soviet Union (NIS) Cohort (n = 3187) and the Latin American Screening (LAMS) Study (n = 12,114) were combined, and co-factors associated with progression to CIN1, CIN2 and CIN3 were analysed using multinomial logistic regression models with all covariates recorded at baseline. HR-HPV-positive women (n = 1105) represented a subcohort of all 1865 women prospectively followed up in both studies. Altogether, 90 (4.8%), 39 (2.1%) and 14 (1.4%) cases progressed to CIN1, CIN2 and CIN3, respectively. Baseline HR-HPV was the single most powerful predictor of incident CIN1, CIN2 and CIN3. When controlled for residual HPV confounding by analysing HR-HPV-positive women only, the risk profiles of incident CIN1, CIN2 and CIN3 were unique. Completely different HPV co-factors were associated with progression to CIN1, CIN2 and CIN3 in univariate and multivariate analyses, irrespective of whether non-progression, CIN1 or CIN2 was used as the reference outcome. HPV co-factors associated with progression to CIN1, CIN2 and CIN3 display unique profiles, implicating genuine biological differences between the three CIN grades, which prompts us to re-visit the concept of combining CIN2 with CIN3 or CIN1.

Authors+Show Affiliations

Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, 20521 Turku, Finland. kari.syrjanen@tyks.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21571974

Citation

Syrjänen, K, et al. "Co-factors of High-risk Human Papillomavirus Infections Display Unique Profiles in Incident CIN1, CIN2 and CIN3." International Journal of STD & AIDS, vol. 22, no. 5, 2011, pp. 263-72.
Syrjänen K, Shabalova I, Naud P, et al. Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3. Int J STD AIDS. 2011;22(5):263-72.
Syrjänen, K., Shabalova, I., Naud, P., Derchain, S., Sarian, L., Kozachenko, V., Zakharchenko, S., Roteli-Martins, C., Nerovjna, R., Longatto-Filho, A., Kljukina, L., Tatti, S., Branovskaja, M., Branca, M., Grunjberga, V., Erzen, M., Juschenko, A., Hammes, L. S., Costa, S., ... Syrjänen, S. (2011). Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3. International Journal of STD & AIDS, 22(5), 263-72. https://doi.org/10.1258/ijsa.2009.009280
Syrjänen K, et al. Co-factors of High-risk Human Papillomavirus Infections Display Unique Profiles in Incident CIN1, CIN2 and CIN3. Int J STD AIDS. 2011;22(5):263-72. PubMed PMID: 21571974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3. AU - Syrjänen,K, AU - Shabalova,I, AU - Naud,P, AU - Derchain,S, AU - Sarian,L, AU - Kozachenko,V, AU - Zakharchenko,S, AU - Roteli-Martins,C, AU - Nerovjna,R, AU - Longatto-Filho,A, AU - Kljukina,L, AU - Tatti,S, AU - Branovskaja,M, AU - Branca,M, AU - Grunjberga,V, AU - Erzen,M, AU - Juschenko,A, AU - Hammes,L Serpa, AU - Costa,S, AU - Podistov,J, AU - Syrjänen,S, AU - ,, AU - ,, AU - ,, PY - 2011/5/17/entrez PY - 2011/5/17/pubmed PY - 2011/8/24/medline SP - 263 EP - 72 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 22 IS - 5 N2 - In addition to oncogenic 'high-risk' human papillomaviruses (HR-HPV), several co-factors are needed in cervical carcinogenesis, but it is poorly understood whether these HPV co-factors associated with incident cervical intraepithelial neoplasia (CIN) grade 1 are different from those required for progression to CIN2 and CIN3. To gain further insights into the true biological differences between CIN1, CIN2 and CIN3, we assessed HPV co-factors increasing the risk of incident CIN1, CIN2 and CIN3. Data from the New Independent States of the Former Soviet Union (NIS) Cohort (n = 3187) and the Latin American Screening (LAMS) Study (n = 12,114) were combined, and co-factors associated with progression to CIN1, CIN2 and CIN3 were analysed using multinomial logistic regression models with all covariates recorded at baseline. HR-HPV-positive women (n = 1105) represented a subcohort of all 1865 women prospectively followed up in both studies. Altogether, 90 (4.8%), 39 (2.1%) and 14 (1.4%) cases progressed to CIN1, CIN2 and CIN3, respectively. Baseline HR-HPV was the single most powerful predictor of incident CIN1, CIN2 and CIN3. When controlled for residual HPV confounding by analysing HR-HPV-positive women only, the risk profiles of incident CIN1, CIN2 and CIN3 were unique. Completely different HPV co-factors were associated with progression to CIN1, CIN2 and CIN3 in univariate and multivariate analyses, irrespective of whether non-progression, CIN1 or CIN2 was used as the reference outcome. HPV co-factors associated with progression to CIN1, CIN2 and CIN3 display unique profiles, implicating genuine biological differences between the three CIN grades, which prompts us to re-visit the concept of combining CIN2 with CIN3 or CIN1. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/21571974/Co_factors_of_high_risk_human_papillomavirus_infections_display_unique_profiles_in_incident_CIN1_CIN2_and_CIN3_ L2 - http://journals.sagepub.com/doi/full/10.1258/ijsa.2009.009280?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -