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Diagnostic accuracy of ACR/EULAR 2010 criteria for rheumatoid arthritis in a 2-year cohort.
J Rheumatol. 2011 Jul; 38(7):1250-7.JR

Abstract

OBJECTIVE

To evaluate the diagnostic accuracy of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and 1987 ACR criteria for rheumatoid arthritis (RA), and the respective role of the algorithm and scoring of the ACR/EULAR.

METHODS

In total, 270 patients with recent-onset arthritis of < 1 year duration were included prospectively between 1995 and 1997 and followed for 2 years. RA was defined as the combination, at completion of followup, of RA diagnosed by an office-based rheumatologist and treatment with a disease-modifying antirheumatic drug or glucocorticoid. We compared the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the criteria sets in the overall population, in the subgroup meeting the tree condition for ACR/EULAR scoring, and in the overall population classified according the full tree.

RESULTS

At baseline, 111 of the 270 patients had better alternative diagnoses and 16 had erosions typical for RA; of the 143 remaining patients, 52 had more than 6 ACR/EULAR 2010 points (indicating definite RA) and 91 had fewer than 6 points. After 2 years, 11/16 patients with erosions and 40/52 with more than 6 points had RA. 100 of the 270 patients met the reference standard for RA. Sensitivity, specificity, PPV, and NPV of the ACR/EULAR (full tree) were 51/100 (51%), 153/170 (90%), 51/68 (75.4%), and 153/202 (75.7%), respectively. Diagnostic accuracies of the ACR/EULAR score and ACR 1987 criteria were not statistically different.

CONCLUSION

Much of the improvement of the ACR/EULAR criteria was ascribable to the use of exclusion criteria in the algorithm.

Authors+Show Affiliations

Rheumatology Unit, University Hospital, Brest, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21572146

Citation

Varache, Sophie, et al. "Diagnostic Accuracy of ACR/EULAR 2010 Criteria for Rheumatoid Arthritis in a 2-year Cohort." The Journal of Rheumatology, vol. 38, no. 7, 2011, pp. 1250-7.
Varache S, Cornec D, Morvan J, et al. Diagnostic accuracy of ACR/EULAR 2010 criteria for rheumatoid arthritis in a 2-year cohort. J Rheumatol. 2011;38(7):1250-7.
Varache, S., Cornec, D., Morvan, J., Devauchelle-Pensec, V., Berthelot, J. M., Le Henaff-Bourhis, C., Hoang, S., Thorel, J. B., Martin, A., Chalès, G., Nowak, E., Jousse-Joulin, S., Youinou, P., & Saraux, A. (2011). Diagnostic accuracy of ACR/EULAR 2010 criteria for rheumatoid arthritis in a 2-year cohort. The Journal of Rheumatology, 38(7), 1250-7. https://doi.org/10.3899/jrheum.101227
Varache S, et al. Diagnostic Accuracy of ACR/EULAR 2010 Criteria for Rheumatoid Arthritis in a 2-year Cohort. J Rheumatol. 2011;38(7):1250-7. PubMed PMID: 21572146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic accuracy of ACR/EULAR 2010 criteria for rheumatoid arthritis in a 2-year cohort. AU - Varache,Sophie, AU - Cornec,Divi, AU - Morvan,Johanne, AU - Devauchelle-Pensec,Valérie, AU - Berthelot,Jean-Marie, AU - Le Henaff-Bourhis,Catherine, AU - Hoang,Sylvie, AU - Thorel,Jean-Baptiste, AU - Martin,Antoine, AU - Chalès,Gérard, AU - Nowak,Emmanuel, AU - Jousse-Joulin,Sandrine, AU - Youinou,Pierre, AU - Saraux,Alain, Y1 - 2011/05/15/ PY - 2011/5/17/entrez PY - 2011/5/17/pubmed PY - 2012/1/21/medline SP - 1250 EP - 7 JF - The Journal of rheumatology JO - J Rheumatol VL - 38 IS - 7 N2 - OBJECTIVE: To evaluate the diagnostic accuracy of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and 1987 ACR criteria for rheumatoid arthritis (RA), and the respective role of the algorithm and scoring of the ACR/EULAR. METHODS: In total, 270 patients with recent-onset arthritis of < 1 year duration were included prospectively between 1995 and 1997 and followed for 2 years. RA was defined as the combination, at completion of followup, of RA diagnosed by an office-based rheumatologist and treatment with a disease-modifying antirheumatic drug or glucocorticoid. We compared the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the criteria sets in the overall population, in the subgroup meeting the tree condition for ACR/EULAR scoring, and in the overall population classified according the full tree. RESULTS: At baseline, 111 of the 270 patients had better alternative diagnoses and 16 had erosions typical for RA; of the 143 remaining patients, 52 had more than 6 ACR/EULAR 2010 points (indicating definite RA) and 91 had fewer than 6 points. After 2 years, 11/16 patients with erosions and 40/52 with more than 6 points had RA. 100 of the 270 patients met the reference standard for RA. Sensitivity, specificity, PPV, and NPV of the ACR/EULAR (full tree) were 51/100 (51%), 153/170 (90%), 51/68 (75.4%), and 153/202 (75.7%), respectively. Diagnostic accuracies of the ACR/EULAR score and ACR 1987 criteria were not statistically different. CONCLUSION: Much of the improvement of the ACR/EULAR criteria was ascribable to the use of exclusion criteria in the algorithm. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/21572146/Diagnostic_accuracy_of_ACR/EULAR_2010_criteria_for_rheumatoid_arthritis_in_a_2_year_cohort_ DB - PRIME DP - Unbound Medicine ER -