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Healthy subjects with a family history of alcoholism show increased stimulative subjective effects of alcohol.
Alcohol Clin Exp Res. 2011 Aug; 35(8):1426-34.AC

Abstract

BACKGROUND

Research has shown that subjects with a family history positive (FHP) of alcoholism are at increased risk for alcoholism and that this group reacts differently to alcohol than family history negative (FHN) subjects. These different levels of sensitivity may make FHP persons more likely to consume alcohol. Here, we tested the hypothesis that subjects FHP for type 1 alcoholism (according to Cloninger) are more sensitive than control subjects to the stimulative, properties of alcohol following a single moderate dose of alcohol.

METHODS

Fifty-one healthy men and women (22 FHP and 29 FHN) participated in 2 laboratory sessions, in which they consumed a beverage containing ethanol (0.6 g/kg in juice) or placebo (juice alone) in a randomized order. Primary dependent measures were self-report questionnaires of mood states.

RESULTS

Subjects with family history of type 1 alcoholism showed increased stimulative responses and an elevated positive mood state after ethanol compared to controls.

CONCLUSIONS

At this moderate dose, ethanol increased stimulative subjective responses in individuals who were "family history positive." This enhanced sensitivity could motivate to exaggerated drinking and thereby increase the risk for developing alcoholism.

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Authors+Show Affiliations

Söderpalm Gordh AH
Institute of Neuroscience and Neurophysiology, Section of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg, Sweden. anna.soderpalm@neuro.gu.se
Söderpalm B
No affiliation info available

MeSH

AdultAlcohol DrinkingAlcoholismBreath TestsCentral Nervous System DepressantsEthanolFamilyFemaleHumansMalePlacebosPsychometricsPsychomotor PerformanceRandom AllocationRiskRisk FactorsYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21575013

Citation

Söderpalm Gordh, Anna H V., and Bo Söderpalm. "Healthy Subjects With a Family History of Alcoholism Show Increased Stimulative Subjective Effects of Alcohol." Alcoholism, Clinical and Experimental Research, vol. 35, no. 8, 2011, pp. 1426-34.
Söderpalm Gordh AH, Söderpalm B. Healthy subjects with a family history of alcoholism show increased stimulative subjective effects of alcohol. Alcohol Clin Exp Res. 2011;35(8):1426-34.
Söderpalm Gordh, A. H., & Söderpalm, B. (2011). Healthy subjects with a family history of alcoholism show increased stimulative subjective effects of alcohol. Alcoholism, Clinical and Experimental Research, 35(8), 1426-34. https://doi.org/10.1111/j.1530-0277.2011.01478.x
Söderpalm Gordh AH, Söderpalm B. Healthy Subjects With a Family History of Alcoholism Show Increased Stimulative Subjective Effects of Alcohol. Alcohol Clin Exp Res. 2011;35(8):1426-34. PubMed PMID: 21575013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healthy subjects with a family history of alcoholism show increased stimulative subjective effects of alcohol. AU - Söderpalm Gordh,Anna H V, AU - Söderpalm,Bo, Y1 - 2011/05/16/ PY - 2011/5/18/entrez PY - 2011/5/18/pubmed PY - 2012/1/24/medline SP - 1426 EP - 34 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 35 IS - 8 N2 - BACKGROUND: Research has shown that subjects with a family history positive (FHP) of alcoholism are at increased risk for alcoholism and that this group reacts differently to alcohol than family history negative (FHN) subjects. These different levels of sensitivity may make FHP persons more likely to consume alcohol. Here, we tested the hypothesis that subjects FHP for type 1 alcoholism (according to Cloninger) are more sensitive than control subjects to the stimulative, properties of alcohol following a single moderate dose of alcohol. METHODS: Fifty-one healthy men and women (22 FHP and 29 FHN) participated in 2 laboratory sessions, in which they consumed a beverage containing ethanol (0.6 g/kg in juice) or placebo (juice alone) in a randomized order. Primary dependent measures were self-report questionnaires of mood states. RESULTS: Subjects with family history of type 1 alcoholism showed increased stimulative responses and an elevated positive mood state after ethanol compared to controls. CONCLUSIONS: At this moderate dose, ethanol increased stimulative subjective responses in individuals who were "family history positive." This enhanced sensitivity could motivate to exaggerated drinking and thereby increase the risk for developing alcoholism. SN - 1530-0277 UR - https://www.unboundmedicine.com/medline/citation/21575013/Healthy_subjects_with_a_family_history_of_alcoholism_show_increased_stimulative_subjective_effects_of_alcohol_ L2 - https://doi.org/10.1111/j.1530-0277.2011.01478.x DB - PRIME DP - Unbound Medicine ER -