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Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally.
Vaccine. 2011 Jul 12; 29(31):4953-62.V

Abstract

Tri-methyl chitosan synthesis accompanies polymer chain scission, which may affect the carrier and adjuvant properties of the polymer. The main objective of this study was to synthesize the tri-methylated chitosan using mild (TMC-M) and conventional (TMC) method and compare their efficacy as nasal vaccine delivery vehicle. During in vitro studies TMC-M nanoparticles showed the lowest nasal clearance rate when compared with chitosan (CS) and TMC nanoparticles. The immunogenicity of nanoparticles based delivery system(s) was assessed by measuring anti-HBsAg antibody titer in mice serum and secretions after intranasal administration. The alum based HBsAg vaccine injected subcutaneously was used as positive control. Results indicated that alum based HBsAg induced strong humoral but negligible mucosal immunity. However, TMC-M nanoparticles induced stronger immune response at both of the fronts as compared to generated by CS or TMC nanoparticles. Present study demonstrates that TMC-M can be a better carrier adjuvant for nasal subunit vaccines.

Authors+Show Affiliations

Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar 470003, Madhya Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21575664

Citation

Mangal, Sharad, et al. "Pharmaceutical and Immunological Evaluation of Mucoadhesive Nanoparticles Based Delivery System(s) Administered Intranasally." Vaccine, vol. 29, no. 31, 2011, pp. 4953-62.
Mangal S, Pawar D, Garg NK, et al. Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally. Vaccine. 2011;29(31):4953-62.
Mangal, S., Pawar, D., Garg, N. K., Jain, A. K., Vyas, S. P., Rao, D. S., & Jaganathan, K. S. (2011). Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally. Vaccine, 29(31), 4953-62. https://doi.org/10.1016/j.vaccine.2011.04.112
Mangal S, et al. Pharmaceutical and Immunological Evaluation of Mucoadhesive Nanoparticles Based Delivery System(s) Administered Intranasally. Vaccine. 2011 Jul 12;29(31):4953-62. PubMed PMID: 21575664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmaceutical and immunological evaluation of mucoadhesive nanoparticles based delivery system(s) administered intranasally. AU - Mangal,Sharad, AU - Pawar,Dilip, AU - Garg,Neeraj K, AU - Jain,Arvind K, AU - Vyas,S P, AU - Rao,D S V Raman, AU - Jaganathan,K S, Y1 - 2011/05/14/ PY - 2011/03/17/received PY - 2011/04/26/revised PY - 2011/04/27/accepted PY - 2011/5/18/entrez PY - 2011/5/18/pubmed PY - 2011/10/19/medline SP - 4953 EP - 62 JF - Vaccine JO - Vaccine VL - 29 IS - 31 N2 - Tri-methyl chitosan synthesis accompanies polymer chain scission, which may affect the carrier and adjuvant properties of the polymer. The main objective of this study was to synthesize the tri-methylated chitosan using mild (TMC-M) and conventional (TMC) method and compare their efficacy as nasal vaccine delivery vehicle. During in vitro studies TMC-M nanoparticles showed the lowest nasal clearance rate when compared with chitosan (CS) and TMC nanoparticles. The immunogenicity of nanoparticles based delivery system(s) was assessed by measuring anti-HBsAg antibody titer in mice serum and secretions after intranasal administration. The alum based HBsAg vaccine injected subcutaneously was used as positive control. Results indicated that alum based HBsAg induced strong humoral but negligible mucosal immunity. However, TMC-M nanoparticles induced stronger immune response at both of the fronts as compared to generated by CS or TMC nanoparticles. Present study demonstrates that TMC-M can be a better carrier adjuvant for nasal subunit vaccines. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21575664/Pharmaceutical_and_immunological_evaluation_of_mucoadhesive_nanoparticles_based_delivery_system_s__administered_intranasally_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00678-5 DB - PRIME DP - Unbound Medicine ER -