Prime

Type your tag names separated by a space and hit enter

Relationship between C3 levels and common carotid intima-media thickness in overweight and obese patients.

Abstract

OBJECTIVE

The study aim was to compare C3 levels with the common carotid artery intima-media thickness (CCAIMT) in subjects of both genders, with a wide range of BMI, independently of age, gender, and abdominal obesity.

METHOD

140 euthyroid, mainly overweight/obese subjects (age 18-30 years) were examined. BMI, waist circumference, blood pressure, fasting insulin, glucose, lipids, C3 and C-reactive protein serum concentrations, and insulin resistance degree (estimated by homeostasis model assessment for insulin resistance (HOMAIR)) were measured.

RESULTS

CCA-IMT was positively (p < 0.001) correlated with BMI, waist circumference, systolic and diastolic blood pressures, HOMAIR, and insulin, CRP, and C3 serum levels. The multiple linear regression analysis showed that only male gender and waist circumference maintained an independent relation with the CCA-IMT.

CONCLUSION

This study suggests that central fat accumulation and male gender independently increase the thickness of the arterial wall, whereas inflammation and inflammatory markers do not have an independent effect on this parameter.

Links

  • Publisher Full Text
  • Authors

    , , , , , , , ,

    Source

    Obesity facts 4:2 2011 pg 159-63

    MeSH

    Adult
    Atherosclerosis
    Biological Markers
    Blood Pressure
    Body Mass Index
    C-Reactive Protein
    Carotid Arteries
    Complement C3
    Female
    Humans
    Insulin
    Insulin Resistance
    Linear Models
    Male
    Obesity
    Obesity, Abdominal
    Sex Factors
    Tunica Intima
    Tunica Media
    Waist Circumference
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21577023