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[Significance and motivation of the clinical use of essential fatty acid derivatives, especially gamma-linolenic acid].
Clin Ter 1990; 132(6):383-92CT

Abstract

Although they were discovered in the first half of our century, essential fatty acids have started commanding clinical interest only during the last few years. Their vast possibilities for therapeutic use make basic knowledge of their chemical nature and physiologic significance a necessity. Essential fatty acids (linoleic and alpha-linolenic acid) are important not only in themselves but also as precursors of other polyunsaturated fatty acids. Besides, from some of these compounds an important series of substances is derived, such as prostaglandins, thromboxanes, prostacyclins, and leukotrienes. The sequence of enzymatic reactions on which the biosynthesis of these substances depends is altered in certain human pathologies. The key to the mechanism of action of some oils, such as evening primrose oil, is the fact that it contains as active principle the product of the blocked enzymatic reaction.

Authors+Show Affiliations

Università degli Studi di Bologna, Dipartimento di Biochimica, Centro Ricerche sulla Nutrizione.

Pub Type(s)

Comparative Study
Journal Article
Review

Language

ita

PubMed ID

2158408

Citation

Bordoni, A. "[Significance and Motivation of the Clinical Use of Essential Fatty Acid Derivatives, Especially Gamma-linolenic Acid]." La Clinica Terapeutica, vol. 132, no. 6, 1990, pp. 383-92.
Bordoni A. [Significance and motivation of the clinical use of essential fatty acid derivatives, especially gamma-linolenic acid]. Clin Ter. 1990;132(6):383-92.
Bordoni, A. (1990). [Significance and motivation of the clinical use of essential fatty acid derivatives, especially gamma-linolenic acid]. La Clinica Terapeutica, 132(6), pp. 383-92.
Bordoni A. [Significance and Motivation of the Clinical Use of Essential Fatty Acid Derivatives, Especially Gamma-linolenic Acid]. Clin Ter. 1990 Mar 31;132(6):383-92. PubMed PMID: 2158408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Significance and motivation of the clinical use of essential fatty acid derivatives, especially gamma-linolenic acid]. A1 - Bordoni,A, PY - 1990/3/31/pubmed PY - 1990/3/31/medline PY - 1990/3/31/entrez SP - 383 EP - 92 JF - La Clinica terapeutica JO - Clin Ter VL - 132 IS - 6 N2 - Although they were discovered in the first half of our century, essential fatty acids have started commanding clinical interest only during the last few years. Their vast possibilities for therapeutic use make basic knowledge of their chemical nature and physiologic significance a necessity. Essential fatty acids (linoleic and alpha-linolenic acid) are important not only in themselves but also as precursors of other polyunsaturated fatty acids. Besides, from some of these compounds an important series of substances is derived, such as prostaglandins, thromboxanes, prostacyclins, and leukotrienes. The sequence of enzymatic reactions on which the biosynthesis of these substances depends is altered in certain human pathologies. The key to the mechanism of action of some oils, such as evening primrose oil, is the fact that it contains as active principle the product of the blocked enzymatic reaction. SN - 0009-9074 UR - https://www.unboundmedicine.com/medline/citation/2158408/[Significance_and_motivation_of_the_clinical_use_of_essential_fatty_acid_derivatives_especially_gamma_linolenic_acid]_ DB - PRIME DP - Unbound Medicine ER -