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Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum.
J Ethnopharmacol. 2011 Sep 01; 137(1):141-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

To study the potential benefit of the traditional Mexican medicinal plant Galium mexicanum Kunth (Rubiaceae). Hexane, chloroform, and methanol extracts as well as various fractions from these extracts were tested to determine antibacterial, antifungal, antiparasitic or anti-inflammatory activities in vitro.

MATERIALS AND METHODS

Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Their antibacterial and antifungal activities were assessed on nine bacterial and four fungal strains. Leishmania donovani was used as a protozoan strain for antiparasitic activity. The anti-inflammatory activity of the compounds was investigated by measuring the secretion of interleukin-6 when macrophages were exposed to lipopolysaccharide.

RESULTS

Various extracts and fractions obtained from this plant exhibit antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. Of special interest was the hexane fraction HE 14 b, which show antibacterial (ranging between 67 and 666 μg/ml) and antifungal (at concentrations of 333 μg/ml) activities. Also the hexane fraction HE 5 exhibited antiparasitic activity (at concentrations of 260 μg/ml), whereas the methanol fraction ME 13-15 showed a potent anti-inflammatory activity when compared to dexamethasone. Chemical analyses of the chloroform extract show the presence of triterpenes, saponins, flavonoids, sesquiterpene lactones, and glucosides, but no tannins were detected in the assayed extract.

CONCLUSIONS

The benefit of Galium mexicanum as a traditional medicinal plant was confirmed using antibacterial and antifungal assays in vitro. We also report for the first time, and to the best of our knowledge, antiparasitic and anti-inflammatory activities of this plant.

Authors+Show Affiliations

Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21586319

Citation

Bolivar, Paulina, et al. "Antimicrobial, Anti-inflammatory, Antiparasitic, and Cytotoxic Activities of Galium Mexicanum." Journal of Ethnopharmacology, vol. 137, no. 1, 2011, pp. 141-7.
Bolivar P, Cruz-Paredes C, Hernández LR, et al. Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. J Ethnopharmacol. 2011;137(1):141-7.
Bolivar, P., Cruz-Paredes, C., Hernández, L. R., Juárez, Z. N., Sánchez-Arreola, E., Av-Gay, Y., & Bach, H. (2011). Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. Journal of Ethnopharmacology, 137(1), 141-7. https://doi.org/10.1016/j.jep.2011.04.069
Bolivar P, et al. Antimicrobial, Anti-inflammatory, Antiparasitic, and Cytotoxic Activities of Galium Mexicanum. J Ethnopharmacol. 2011 Sep 1;137(1):141-7. PubMed PMID: 21586319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum. AU - Bolivar,Paulina, AU - Cruz-Paredes,Carla, AU - Hernández,Luis R, AU - Juárez,Zaida N, AU - Sánchez-Arreola,Eugenio, AU - Av-Gay,Yossef, AU - Bach,Horacio, Y1 - 2011/05/06/ PY - 2011/01/14/received PY - 2011/04/18/revised PY - 2011/04/29/accepted PY - 2011/5/19/entrez PY - 2011/5/19/pubmed PY - 2011/12/28/medline SP - 141 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 137 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: To study the potential benefit of the traditional Mexican medicinal plant Galium mexicanum Kunth (Rubiaceae). Hexane, chloroform, and methanol extracts as well as various fractions from these extracts were tested to determine antibacterial, antifungal, antiparasitic or anti-inflammatory activities in vitro. MATERIALS AND METHODS: Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Their antibacterial and antifungal activities were assessed on nine bacterial and four fungal strains. Leishmania donovani was used as a protozoan strain for antiparasitic activity. The anti-inflammatory activity of the compounds was investigated by measuring the secretion of interleukin-6 when macrophages were exposed to lipopolysaccharide. RESULTS: Various extracts and fractions obtained from this plant exhibit antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. Of special interest was the hexane fraction HE 14 b, which show antibacterial (ranging between 67 and 666 μg/ml) and antifungal (at concentrations of 333 μg/ml) activities. Also the hexane fraction HE 5 exhibited antiparasitic activity (at concentrations of 260 μg/ml), whereas the methanol fraction ME 13-15 showed a potent anti-inflammatory activity when compared to dexamethasone. Chemical analyses of the chloroform extract show the presence of triterpenes, saponins, flavonoids, sesquiterpene lactones, and glucosides, but no tannins were detected in the assayed extract. CONCLUSIONS: The benefit of Galium mexicanum as a traditional medicinal plant was confirmed using antibacterial and antifungal assays in vitro. We also report for the first time, and to the best of our knowledge, antiparasitic and anti-inflammatory activities of this plant. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21586319/Antimicrobial_anti_inflammatory_antiparasitic_and_cytotoxic_activities_of_Galium_mexicanum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(11)00324-2 DB - PRIME DP - Unbound Medicine ER -