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Multi-linear regression models predict the effects of water chemistry on acute lead toxicity to Ceriodaphnia dubia and Pimephales promelas.
Comp Biochem Physiol C Toxicol Pharmacol. 2011 Sep; 154(3):137-45.CB

Abstract

The current study examined the acute toxicity of lead (Pb) to Ceriodaphnia dubia and Pimephales promelas in a variety of natural waters. The natural waters were selected to range in pertinent water chemistry parameters such as calcium, pH, total CO(2) and dissolved organic carbon (DOC). Acute toxicity was determined for C. dubia and P. promelas using standard 48h and 96h protocols, respectively. For both organisms acute toxicity varied markedly according to water chemistry, with C. dubia LC50s ranging from 29 to 180μg/L and P. promelas LC50s ranging from 41 to 3598μg/L. Additionally, no Pb toxicity was observed for P. promelas in three alkaline natural waters. With respect to water chemistry parameters, DOC had the strongest protective impact for both organisms. A multi-linear regression (MLR) approach combining previous lab data and the current data was used to identify the relative importance of individual water chemistry components in predicting acute Pb toxicity for both species. As anticipated, the P. promelas best-fit MLR model combined DOC, calcium and pH. Unexpectedly, in the C. dubiaMLR model the importance of pH, TCO(2) and calcium was minimal while DOC and ionic strength were the controlling water quality variables. Adjusted R(2) values of 0.82 and 0.64 for the P. promelas and C. dubia models, respectively, are comparable to previously developed biotic ligand models for other metals.

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Authors+Show Affiliations

Esbaugh AJ
Division of Marine Biology and Fisheries, University of Miami, Rosenstiel School of Marine and Atmospheric Science, 4600 Rickenbacker Causeway, Miami, FL 33149, USA. aesbaugh@rsmas.miami.edu
Brix KV
No affiliation info available
Mager EM
No affiliation info available
Grosell M
No affiliation info available

MeSH

AnimalsCalciumCarbon DioxideCladoceraCyprinidaeFresh WaterHydrogen-Ion ConcentrationLeadLethal Dose 50Linear ModelsNorth AmericaToxicity Tests, AcuteWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21586337

Citation

Esbaugh, A J., et al. "Multi-linear Regression Models Predict the Effects of Water Chemistry On Acute Lead Toxicity to Ceriodaphnia Dubia and Pimephales Promelas." Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, vol. 154, no. 3, 2011, pp. 137-45.
Esbaugh AJ, Brix KV, Mager EM, et al. Multi-linear regression models predict the effects of water chemistry on acute lead toxicity to Ceriodaphnia dubia and Pimephales promelas. Comp Biochem Physiol C Toxicol Pharmacol. 2011;154(3):137-45.
Esbaugh, A. J., Brix, K. V., Mager, E. M., & Grosell, M. (2011). Multi-linear regression models predict the effects of water chemistry on acute lead toxicity to Ceriodaphnia dubia and Pimephales promelas. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 154(3), 137-45. https://doi.org/10.1016/j.cbpc.2011.04.006
Esbaugh AJ, et al. Multi-linear Regression Models Predict the Effects of Water Chemistry On Acute Lead Toxicity to Ceriodaphnia Dubia and Pimephales Promelas. Comp Biochem Physiol C Toxicol Pharmacol. 2011;154(3):137-45. PubMed PMID: 21586337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-linear regression models predict the effects of water chemistry on acute lead toxicity to Ceriodaphnia dubia and Pimephales promelas. AU - Esbaugh,A J, AU - Brix,K V, AU - Mager,E M, AU - Grosell,M, Y1 - 2011/05/07/ PY - 2011/01/31/received PY - 2011/04/20/revised PY - 2011/04/27/accepted PY - 2011/5/19/entrez PY - 2011/5/19/pubmed PY - 2012/1/31/medline SP - 137 EP - 45 JF - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP JO - Comp Biochem Physiol C Toxicol Pharmacol VL - 154 IS - 3 N2 - The current study examined the acute toxicity of lead (Pb) to Ceriodaphnia dubia and Pimephales promelas in a variety of natural waters. The natural waters were selected to range in pertinent water chemistry parameters such as calcium, pH, total CO(2) and dissolved organic carbon (DOC). Acute toxicity was determined for C. dubia and P. promelas using standard 48h and 96h protocols, respectively. For both organisms acute toxicity varied markedly according to water chemistry, with C. dubia LC50s ranging from 29 to 180μg/L and P. promelas LC50s ranging from 41 to 3598μg/L. Additionally, no Pb toxicity was observed for P. promelas in three alkaline natural waters. With respect to water chemistry parameters, DOC had the strongest protective impact for both organisms. A multi-linear regression (MLR) approach combining previous lab data and the current data was used to identify the relative importance of individual water chemistry components in predicting acute Pb toxicity for both species. As anticipated, the P. promelas best-fit MLR model combined DOC, calcium and pH. Unexpectedly, in the C. dubiaMLR model the importance of pH, TCO(2) and calcium was minimal while DOC and ionic strength were the controlling water quality variables. Adjusted R(2) values of 0.82 and 0.64 for the P. promelas and C. dubia models, respectively, are comparable to previously developed biotic ligand models for other metals. SN - 1532-0456 UR - https://www.unboundmedicine.com/medline/citation/21586337/Multi_linear_regression_models_predict_the_effects_of_water_chemistry_on_acute_lead_toxicity_to_Ceriodaphnia_dubia_and_Pimephales_promelas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-0456(11)00074-3 DB - PRIME DP - Unbound Medicine ER -