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Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.
Ann Rheum Dis. 2011 Aug; 70(8):1468-70.AR

Abstract

BACKGROUND

Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA).

OBJECTIVE

To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the Visser decision rule.

METHODS

455 patients with early arthritis were studied. The diagnostic performance of the criteria was evaluated using methotrexate treatment within 1 year, expert opinion RA and erosive disease as 'gold standards'. Erosive disease was defined as a 0-3 year change in radiographic score of ≥5.

RESULTS

The discriminative ability of the three criteria sets (2010 ACR/EULAR, 1987 ACR criteria and Visser algorithm) was similar with areas under the curve of 0.71-0.78 ('gold standard' methotrexate), 0.74-0.80 (gold standard expert opinion RA) and 0.63-0.67 (gold standard erosive disease after 3 years). The sensitivity of the 2010 ACR/EULAR criteria was highest with 0.85 (gold standard methotrexate). 86% of patients with RA and 51% of 'non-RA' patients according to the new criteria used methotrexate.

CONCLUSION

The 2010 ACR/EULAR criteria were slightly more sensitive, but otherwise performed similarly to the older criteria. A high percentage of 'non-RA' patients used methotrexate, the gold standard for RA. The ability of the new criteria to identify patients with erosive disease was low, possibly owing to the effect of intensive treatment.

Authors+Show Affiliations

Department of Rheumatology, Jan van Breemen Research Institute I Reade, Amsterdam, The Netherlands. k.britsemmer@reade.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

21586440

Citation

Britsemmer, Karin, et al. "Validation of the 2010 ACR/EULAR Classification Criteria for Rheumatoid Arthritis: Slight Improvement Over the 1987 ACR Criteria." Annals of the Rheumatic Diseases, vol. 70, no. 8, 2011, pp. 1468-70.
Britsemmer K, Ursum J, Gerritsen M, et al. Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria. Ann Rheum Dis. 2011;70(8):1468-70.
Britsemmer, K., Ursum, J., Gerritsen, M., van Tuyl, L. H., van Tuyl, L., & van Schaardenburg, D. (2011). Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria. Annals of the Rheumatic Diseases, 70(8), 1468-70. https://doi.org/10.1136/ard.2010.148619
Britsemmer K, et al. Validation of the 2010 ACR/EULAR Classification Criteria for Rheumatoid Arthritis: Slight Improvement Over the 1987 ACR Criteria. Ann Rheum Dis. 2011;70(8):1468-70. PubMed PMID: 21586440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria. AU - Britsemmer,Karin, AU - Ursum,Jennie, AU - Gerritsen,Martijn, AU - van Tuyl,L H, AU - van Tuyl,Lilian, AU - van Schaardenburg,Dirkjan, Y1 - 2011/05/17/ PY - 2011/5/19/entrez PY - 2011/5/19/pubmed PY - 2011/12/13/medline SP - 1468 EP - 70 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 70 IS - 8 N2 - BACKGROUND: Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA). OBJECTIVE: To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the Visser decision rule. METHODS: 455 patients with early arthritis were studied. The diagnostic performance of the criteria was evaluated using methotrexate treatment within 1 year, expert opinion RA and erosive disease as 'gold standards'. Erosive disease was defined as a 0-3 year change in radiographic score of ≥5. RESULTS: The discriminative ability of the three criteria sets (2010 ACR/EULAR, 1987 ACR criteria and Visser algorithm) was similar with areas under the curve of 0.71-0.78 ('gold standard' methotrexate), 0.74-0.80 (gold standard expert opinion RA) and 0.63-0.67 (gold standard erosive disease after 3 years). The sensitivity of the 2010 ACR/EULAR criteria was highest with 0.85 (gold standard methotrexate). 86% of patients with RA and 51% of 'non-RA' patients according to the new criteria used methotrexate. CONCLUSION: The 2010 ACR/EULAR criteria were slightly more sensitive, but otherwise performed similarly to the older criteria. A high percentage of 'non-RA' patients used methotrexate, the gold standard for RA. The ability of the new criteria to identify patients with erosive disease was low, possibly owing to the effect of intensive treatment. SN - 1468-2060 UR - https://www.unboundmedicine.com/medline/citation/21586440/Validation_of_the_2010_ACR/EULAR_classification_criteria_for_rheumatoid_arthritis:_slight_improvement_over_the_1987_ACR_criteria_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=21586440 DB - PRIME DP - Unbound Medicine ER -