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Association of human adenovirus-36 in overweight Korean adults.
Int J Obes (Lond) 2012; 36(2):281-5IJ

Abstract

BACKGROUND

Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults.

METHODS

A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23 ≤ BMI<25 kg m(-2) and obese subjects were those with BMI ≥ 25 kg m(-2), according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay.

RESULTS

Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67).

CONCLUSION

Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults.

Authors+Show Affiliations

Department of Biotechnology, The Catholic University of Korea, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21587203

Citation

Na, H-N, et al. "Association of Human Adenovirus-36 in Overweight Korean Adults." International Journal of Obesity (2005), vol. 36, no. 2, 2012, pp. 281-5.
Na HN, Kim J, Lee HS, et al. Association of human adenovirus-36 in overweight Korean adults. Int J Obes (Lond). 2012;36(2):281-5.
Na, H. N., Kim, J., Lee, H. S., Shim, K. W., Kimm, H., Jee, S. H., ... Nam, J. H. (2012). Association of human adenovirus-36 in overweight Korean adults. International Journal of Obesity (2005), 36(2), pp. 281-5. doi:10.1038/ijo.2011.102.
Na HN, et al. Association of Human Adenovirus-36 in Overweight Korean Adults. Int J Obes (Lond). 2012;36(2):281-5. PubMed PMID: 21587203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of human adenovirus-36 in overweight Korean adults. AU - Na,H-N, AU - Kim,J, AU - Lee,H S, AU - Shim,K W, AU - Kimm,H, AU - Jee,S H, AU - Jo,I, AU - Nam,J-H, Y1 - 2011/05/17/ PY - 2011/5/19/entrez PY - 2011/5/19/pubmed PY - 2012/6/23/medline SP - 281 EP - 5 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 36 IS - 2 N2 - BACKGROUND: Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults. METHODS: A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23 ≤ BMI<25 kg m(-2) and obese subjects were those with BMI ≥ 25 kg m(-2), according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay. RESULTS: Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67). CONCLUSION: Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/21587203/Association_of_human_adenovirus_36_in_overweight_Korean_adults_ L2 - http://dx.doi.org/10.1038/ijo.2011.102 DB - PRIME DP - Unbound Medicine ER -