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Does the Mediterranean dietary pattern or the Healthy Diet Index influence the risk of breast cancer in a large British cohort of women?

Abstract

BACKGROUND/OBJECTIVE

To assess the risk of developing breast cancer associated with consumption of two common dietary patterns: a Mediterranean dietary pattern and a dietary pattern, which conforms to the World Health Organization Healthy Diet Index (WHO HDI).

SUBJECTS/METHODS

Dietary data from a 217-item food frequency questionnaire were used to generate two dietary patterns according to pre-defined criteria in women from the UK Women's Cohort Study. Survival analysis using Cox regression was used to estimate hazards ratios for risk of breast cancer adjusted for known confounders.

RESULTS

This analysis included 828 incident cases of breast cancer in 33,731 women with a mean follow-up of 9 years. There were no statistically significant associations between either the Mediterranean dietary pattern or the WHO HDI and risk of breast cancer. In premenopausal women, there was a nonsignificant trend suggesting that increasing compliance with the Mediterranean diet was associated with lower risk of breast cancer. Maximal adherence to the Mediterranean diet was associated with hazards ratio=0.65 (95% confidence interval: 0.42-1.02, P trend=0.09) compared with minimal adherence. In postmenopausal women, no clear trends were observed.

CONCLUSIONS

In this study, no strong association between the risk of breast cancer and the consumption of either a Mediterranean-type diet or one characterized by adherence to the WHO HDI was observed. In premenopausal, but not postmenopausal women, there was a nonsignificant inverse association with increasing adherence to the Mediterranean diet pattern.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK. j.e.cade@leeds.ac.uk

    , ,

    Source

    MeSH

    Adult
    Aged
    Animals
    Body Mass Index
    Breast Neoplasms
    Diet, Mediterranean
    Energy Intake
    Factor Analysis, Statistical
    Feeding Behavior
    Female
    Fishes
    Follow-Up Studies
    Hormone Replacement Therapy
    Humans
    Life Style
    Middle Aged
    Patient Compliance
    Premenopause
    Prevalence
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    United Kingdom
    Vegetables
    World Health Organization

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21587285

    Citation

    Cade, J E., et al. "Does the Mediterranean Dietary Pattern or the Healthy Diet Index Influence the Risk of Breast Cancer in a Large British Cohort of Women?" European Journal of Clinical Nutrition, vol. 65, no. 8, 2011, pp. 920-8.
    Cade JE, Taylor EF, Burley VJ, et al. Does the Mediterranean dietary pattern or the Healthy Diet Index influence the risk of breast cancer in a large British cohort of women? Eur J Clin Nutr. 2011;65(8):920-8.
    Cade, J. E., Taylor, E. F., Burley, V. J., & Greenwood, D. C. (2011). Does the Mediterranean dietary pattern or the Healthy Diet Index influence the risk of breast cancer in a large British cohort of women? European Journal of Clinical Nutrition, 65(8), pp. 920-8. doi:10.1038/ejcn.2011.69.
    Cade JE, et al. Does the Mediterranean Dietary Pattern or the Healthy Diet Index Influence the Risk of Breast Cancer in a Large British Cohort of Women. Eur J Clin Nutr. 2011;65(8):920-8. PubMed PMID: 21587285.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Does the Mediterranean dietary pattern or the Healthy Diet Index influence the risk of breast cancer in a large British cohort of women? AU - Cade,J E, AU - Taylor,E F, AU - Burley,V J, AU - Greenwood,D C, Y1 - 2011/05/18/ PY - 2011/5/19/entrez PY - 2011/5/19/pubmed PY - 2011/12/16/medline SP - 920 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 65 IS - 8 N2 - BACKGROUND/OBJECTIVE: To assess the risk of developing breast cancer associated with consumption of two common dietary patterns: a Mediterranean dietary pattern and a dietary pattern, which conforms to the World Health Organization Healthy Diet Index (WHO HDI). SUBJECTS/METHODS: Dietary data from a 217-item food frequency questionnaire were used to generate two dietary patterns according to pre-defined criteria in women from the UK Women's Cohort Study. Survival analysis using Cox regression was used to estimate hazards ratios for risk of breast cancer adjusted for known confounders. RESULTS: This analysis included 828 incident cases of breast cancer in 33,731 women with a mean follow-up of 9 years. There were no statistically significant associations between either the Mediterranean dietary pattern or the WHO HDI and risk of breast cancer. In premenopausal women, there was a nonsignificant trend suggesting that increasing compliance with the Mediterranean diet was associated with lower risk of breast cancer. Maximal adherence to the Mediterranean diet was associated with hazards ratio=0.65 (95% confidence interval: 0.42-1.02, P trend=0.09) compared with minimal adherence. In postmenopausal women, no clear trends were observed. CONCLUSIONS: In this study, no strong association between the risk of breast cancer and the consumption of either a Mediterranean-type diet or one characterized by adherence to the WHO HDI was observed. In premenopausal, but not postmenopausal women, there was a nonsignificant inverse association with increasing adherence to the Mediterranean diet pattern. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21587285/Does_the_Mediterranean_dietary_pattern_or_the_Healthy_Diet_Index_influence_the_risk_of_breast_cancer_in_a_large_British_cohort_of_women L2 - http://dx.doi.org/10.1038/ejcn.2011.69 DB - PRIME DP - Unbound Medicine ER -