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Coffee consumption and the risk of venous thromboembolism: the Tromsø study.

Abstract

BACKGROUND

Several studies have investigated the association between coffee consumption and cardiovascular disease, but little is known about coffee intake and the risk of venous thromboembolism (VTE).

OBJECTIVE

The aim of this prospective cohort study was to investigate the association between coffee consumption and the risk of incident VTE in a general population.

METHODS

Information about coffee consumption habits was obtained with a self-administered questionnaire in 26, 755 subjects, aged 25-97 years, who participated in the fourth survey of the Tromsø study (1994-1995). Incident VTE events were registered until the end of follow-up, 1 September 2007.

RESULTS

There were 462 incident VTE events (1.60 per 1000 person-years, 95% confidence interval [CI] 1.46-1.75) during a median of 12.5 years of follow-up. A daily consumption of three to four cups was borderline associated (hazard ratio [HR] 0.70; 95% CI 0.48-1.02) and a daily consumption of five to six cups (HR 0.67; 95% CI 0.45-0.97) was significantly associated with reduced risk of VTE as compared with coffee abstainers in multivariable analysis adjusted for age, sex, body mass index (BMI), smoking status, physical activity, diabetes, history of cardiovascular disease and cancer. Similar risk estimates were found for provoked and unprovoked VTE, and in sex-stratified analyses.

CONCLUSION

Our findings suggest a possible U-shaped relationship between coffee consumption and VTE, and that moderate coffee consumption may be associated with a reduced risk of VTE. However, more studies are needed to establish whether moderate coffee consumption is inversely associated with the risk of VTE.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Medicine, University of Tromsø, Tromsø, Norway. kristin.f.enga@uit.no

    , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Coffee
    Cohort Studies
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk Factors
    Sex Factors
    Surveys and Questionnaires
    Venous Thromboembolism

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    21592303

    Citation

    Enga, K F., et al. "Coffee Consumption and the Risk of Venous Thromboembolism: the Tromsø Study." Journal of Thrombosis and Haemostasis : JTH, vol. 9, no. 7, 2011, pp. 1334-9.
    Enga KF, Braekkan SK, Hansen-Krone IJ, et al. Coffee consumption and the risk of venous thromboembolism: the Tromsø study. J Thromb Haemost. 2011;9(7):1334-9.
    Enga, K. F., Braekkan, S. K., Hansen-Krone, I. J., Wilsgaard, T., & Hansen, J. B. (2011). Coffee consumption and the risk of venous thromboembolism: the Tromsø study. Journal of Thrombosis and Haemostasis : JTH, 9(7), pp. 1334-9. doi:10.1111/j.1538-7836.2011.04353.x.
    Enga KF, et al. Coffee Consumption and the Risk of Venous Thromboembolism: the Tromsø Study. J Thromb Haemost. 2011;9(7):1334-9. PubMed PMID: 21592303.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coffee consumption and the risk of venous thromboembolism: the Tromsø study. AU - Enga,K F, AU - Braekkan,S K, AU - Hansen-Krone,I J, AU - Wilsgaard,T, AU - Hansen,J-B, PY - 2011/5/20/entrez PY - 2011/5/20/pubmed PY - 2012/2/3/medline SP - 1334 EP - 9 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 9 IS - 7 N2 - BACKGROUND: Several studies have investigated the association between coffee consumption and cardiovascular disease, but little is known about coffee intake and the risk of venous thromboembolism (VTE). OBJECTIVE: The aim of this prospective cohort study was to investigate the association between coffee consumption and the risk of incident VTE in a general population. METHODS: Information about coffee consumption habits was obtained with a self-administered questionnaire in 26, 755 subjects, aged 25-97 years, who participated in the fourth survey of the Tromsø study (1994-1995). Incident VTE events were registered until the end of follow-up, 1 September 2007. RESULTS: There were 462 incident VTE events (1.60 per 1000 person-years, 95% confidence interval [CI] 1.46-1.75) during a median of 12.5 years of follow-up. A daily consumption of three to four cups was borderline associated (hazard ratio [HR] 0.70; 95% CI 0.48-1.02) and a daily consumption of five to six cups (HR 0.67; 95% CI 0.45-0.97) was significantly associated with reduced risk of VTE as compared with coffee abstainers in multivariable analysis adjusted for age, sex, body mass index (BMI), smoking status, physical activity, diabetes, history of cardiovascular disease and cancer. Similar risk estimates were found for provoked and unprovoked VTE, and in sex-stratified analyses. CONCLUSION: Our findings suggest a possible U-shaped relationship between coffee consumption and VTE, and that moderate coffee consumption may be associated with a reduced risk of VTE. However, more studies are needed to establish whether moderate coffee consumption is inversely associated with the risk of VTE. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/21592303/Coffee_consumption_and_the_risk_of_venous_thromboembolism:_the_Tromsø_study_ L2 - https://doi.org/10.1111/j.1538-7836.2011.04353.x DB - PRIME DP - Unbound Medicine ER -