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Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion.
Colloids Surf B Biointerfaces. 2011 Sep 01; 86(2):275-84.CS

Abstract

In the current study Ibuprofen was embedded in a methacrylate copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion (HME) processing. The obtained granules were incorporated in orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as sodium croscarmellose and crosslinked polyvinylpyrrolidone grades while a direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets which included porosity, hardness, friability and dissolution profiles were further evaluated and compared with Nurofen® Meltlet ODTs. The taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and improved tablet palatability.

Authors+Show Affiliations

Evonik Röhm GmbH, Kirschenalle, Darmstadt 64293, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21592751

Citation

Gryczke, Andreas, et al. "Development and Evaluation of Orally Disintegrating Tablets (ODTs) Containing Ibuprofen Granules Prepared By Hot Melt Extrusion." Colloids and Surfaces. B, Biointerfaces, vol. 86, no. 2, 2011, pp. 275-84.
Gryczke A, Schminke S, Maniruzzaman M, et al. Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids Surf B Biointerfaces. 2011;86(2):275-84.
Gryczke, A., Schminke, S., Maniruzzaman, M., Beck, J., & Douroumis, D. (2011). Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. Colloids and Surfaces. B, Biointerfaces, 86(2), 275-84. https://doi.org/10.1016/j.colsurfb.2011.04.007
Gryczke A, et al. Development and Evaluation of Orally Disintegrating Tablets (ODTs) Containing Ibuprofen Granules Prepared By Hot Melt Extrusion. Colloids Surf B Biointerfaces. 2011 Sep 1;86(2):275-84. PubMed PMID: 21592751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion. AU - Gryczke,Andreas, AU - Schminke,Silke, AU - Maniruzzaman,Mohammed, AU - Beck,Julien, AU - Douroumis,Dennis, Y1 - 2011/04/13/ PY - 2011/01/31/received PY - 2011/03/31/revised PY - 2011/04/05/accepted PY - 2011/5/20/entrez PY - 2011/5/20/pubmed PY - 2011/9/21/medline SP - 275 EP - 84 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 86 IS - 2 N2 - In the current study Ibuprofen was embedded in a methacrylate copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion (HME) processing. The obtained granules were incorporated in orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as sodium croscarmellose and crosslinked polyvinylpyrrolidone grades while a direct compression process was used to compress the ODTs under various compaction forces to optimize tablet robustness. The properties of the compressed tablets which included porosity, hardness, friability and dissolution profiles were further evaluated and compared with Nurofen® Meltlet ODTs. The taste and sensory evaluation in human volunteers demonstrated excellence in masking the bitter active and improved tablet palatability. SN - 1873-4367 UR - https://www.unboundmedicine.com/medline/citation/21592751/Development_and_evaluation_of_orally_disintegrating_tablets__ODTs__containing_Ibuprofen_granules_prepared_by_hot_melt_extrusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0927-7765(11)00198-6 DB - PRIME DP - Unbound Medicine ER -