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Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.
J Clin Virol 2011; 51(3):205-8JC

Abstract

BACKGROUND

Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir.

OBJECTIVES

To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation.

STUDY DESIGN

A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010.

RESULTS

H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised.

CONCLUSION

In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.

Authors+Show Affiliations

Centro Nacional de Gripe, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. jledesmam@isciii.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21592854

Citation

Ledesma, Juan, et al. "Oseltamivir-resistant Pandemic Influenza a (H1N1) 2009 Viruses in Spain." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 51, no. 3, 2011, pp. 205-8.
Ledesma J, Vicente D, Pozo F, et al. Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. J Clin Virol. 2011;51(3):205-8.
Ledesma, J., Vicente, D., Pozo, F., Cilla, G., Castro, S. P., Fernández, J. S., ... Breña, P. P. (2011). Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 51(3), pp. 205-8. doi:10.1016/j.jcv.2011.04.008.
Ledesma J, et al. Oseltamivir-resistant Pandemic Influenza a (H1N1) 2009 Viruses in Spain. J Clin Virol. 2011;51(3):205-8. PubMed PMID: 21592854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain. AU - Ledesma,Juan, AU - Vicente,Diego, AU - Pozo,Francisco, AU - Cilla,Gustavo, AU - Castro,Sonia Pérez, AU - Fernández,Jonathan Suárez, AU - Ruiz,Mercedes Pérez, AU - Navarro,José María, AU - Galán,Juan Carlos, AU - Fernández,Mirian, AU - Reina,Jordi, AU - Larrauri,Amparo, AU - Cuevas,María Teresa, AU - Casas,Inmaculada, AU - Breña,Pilar Pérez, AU - ,, Y1 - 2011/05/17/ PY - 2010/11/30/received PY - 2011/04/11/revised PY - 2011/04/20/accepted PY - 2011/5/20/entrez PY - 2011/5/20/pubmed PY - 2011/9/29/medline SP - 205 EP - 8 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 51 IS - 3 N2 - BACKGROUND: Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir. OBJECTIVES: To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation. STUDY DESIGN: A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010. RESULTS: H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised. CONCLUSION: In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/21592854/Oseltamivir_resistant_pandemic_influenza_a__H1N1__2009_viruses_in_Spain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(11)00148-X DB - PRIME DP - Unbound Medicine ER -