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Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease.
J Alzheimers Dis 2011; 26(1):59-68JA

Abstract

Oxidative stress has been associated with normal aging and Alzheimer's disease (AD). However, little is known about oxidative stress in mild cognitive impairment (MCI) patients who present a high risk for developing AD. The aim of this study was to investigate plasma production of the lipid peroxidation marker, malonaldehyde (MDA) and to determine, in erythrocytes, the enzymatic antioxidant activity of catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S-transferase (GST) in 33 individuals with MCI, 29 with mild probable AD and 26 healthy aged subjects. GR/GPx activity ratio was calculated to better assess antioxidant defenses. The relationship between oxidative stress and cognitive performance was also evaluated by the Mini Mental State Examination (MMSE). AD patients showed higher MDA levels than both MCI and healthy elderly subjects. MCI subjects also exhibited higher MDA levels compared to controls. Catalase and GPx activity were similar in MCI and healthy individuals but higher in AD. GR activity was lower in MCI and AD patients than in healthy aged subjects. Additionally, GR/GPx ratio was higher in healthy aged subjects, intermediate in MCI and lower in AD patients. No differences in GST activity were detected among the groups. MMSE was negatively associated with MDA levels (r = -0.31, p = 0.028) and positively correlated with GR/GPx ratio in AD patients (r = 0.68, p < 0.001). MDA levels were also negatively correlated to GR/GPx ratio (r = -0.31, p = 0.029) in the AD group. These results suggest that high lipid peroxidation and decreased antioxidant defenses may be present early in cognitive disorders.

Authors+Show Affiliations

Department of Clinical Chemistry and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21593563

Citation

Torres, Larissa Lobo, et al. "Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 26, no. 1, 2011, pp. 59-68.
Torres LL, Quaglio NB, de Souza GT, et al. Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2011;26(1):59-68.
Torres, L. L., Quaglio, N. B., de Souza, G. T., Garcia, R. T., Dati, L. M., Moreira, W. L., ... Marcourakis, T. (2011). Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 26(1), pp. 59-68. doi:10.3233/JAD-2011-110284.
Torres LL, et al. Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease. J Alzheimers Dis. 2011;26(1):59-68. PubMed PMID: 21593563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripheral oxidative stress biomarkers in mild cognitive impairment and Alzheimer's disease. AU - Torres,Larissa Lobo, AU - Quaglio,Nathalia Barbosa, AU - de Souza,Gisele Tavares, AU - Garcia,Raphael Tamborelli, AU - Dati,Lívia Mendonça Munhoz, AU - Moreira,Wallace Luiz, AU - Loureiro,Ana Paula de Melo, AU - de Souza-Talarico,Juliana Nery, AU - Smid,Jerusa, AU - Porto,Cláudia Selito, AU - Bottino,Cássio Machado de Campos, AU - Nitrini,Ricardo, AU - Barros,Silvia Berlanga de Moraes, AU - Camarini,Rosana, AU - Marcourakis,Tania, PY - 2011/5/20/entrez PY - 2011/5/20/pubmed PY - 2012/1/11/medline SP - 59 EP - 68 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 26 IS - 1 N2 - Oxidative stress has been associated with normal aging and Alzheimer's disease (AD). However, little is known about oxidative stress in mild cognitive impairment (MCI) patients who present a high risk for developing AD. The aim of this study was to investigate plasma production of the lipid peroxidation marker, malonaldehyde (MDA) and to determine, in erythrocytes, the enzymatic antioxidant activity of catalase, glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione S-transferase (GST) in 33 individuals with MCI, 29 with mild probable AD and 26 healthy aged subjects. GR/GPx activity ratio was calculated to better assess antioxidant defenses. The relationship between oxidative stress and cognitive performance was also evaluated by the Mini Mental State Examination (MMSE). AD patients showed higher MDA levels than both MCI and healthy elderly subjects. MCI subjects also exhibited higher MDA levels compared to controls. Catalase and GPx activity were similar in MCI and healthy individuals but higher in AD. GR activity was lower in MCI and AD patients than in healthy aged subjects. Additionally, GR/GPx ratio was higher in healthy aged subjects, intermediate in MCI and lower in AD patients. No differences in GST activity were detected among the groups. MMSE was negatively associated with MDA levels (r = -0.31, p = 0.028) and positively correlated with GR/GPx ratio in AD patients (r = 0.68, p < 0.001). MDA levels were also negatively correlated to GR/GPx ratio (r = -0.31, p = 0.029) in the AD group. These results suggest that high lipid peroxidation and decreased antioxidant defenses may be present early in cognitive disorders. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/21593563/Peripheral_oxidative_stress_biomarkers_in_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-2011-110284 DB - PRIME DP - Unbound Medicine ER -