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Selenium supplementation and exercise: effect on oxidant stress in overweight adults.
Obesity (Silver Spring). 2012 Apr; 20(4):794-801.O

Abstract

Both obesity and acute high-intensity exercise increase oxidant stress levels. This study investigates whether selenium (Se) supplementation could be a potential effective therapy to reduce obesity-associated oxidant stress and exercise-induced oxidant stress. Ten normal-weight (NW) (22.80 ± 0.41 kg/m(2)) and ten overweight (OW) healthy subjects (28.00 ± 0.81 kg/m(2)) were assessed during a randomized double-blind Se supplementation study (200 µg sodium selenite/day for 3 weeks) with a 3-week placebo control and inversion of treatment periods. Blood levels of lipid hydroperoxide (LH), superoxide dismutase (SOD), erythrocyte glutathione (GSH), and total antioxidant status (TAS), were measured at rest, pre-, and postexercise (30 min 70% VO(2) max before and after treatment (pretreatment (week 0 and 12) and post-treatment (week 3 or 15)). At rest, compared to placebo, Se supplementation had no significant effect on LH, SOD, GSH, and TAS levels. However, Se supplementation decreased LH levels in the OW group, immediately postexercise (-0.25 ± 0.12 µmol/l, P = 0.05) compared to placebo treatment. Postexercise, with or without Se supplementation, no changes in TAS, SOD, and GSH levels were observed in both the NW and OW group. This study has highlighted a potential benefit of Se in reducing LH levels postexercise in OW individuals. Given that oxidant stress is a predictor of coronary events, it is imperative to better understand oxidant stress-related responses to lifestyle factors (in particular "high-risk" population groups) and potential antioxidant therapy.

Authors+Show Affiliations

Department of Sport and Exercise Sciences, University of Bedfordshire, Bedford, UK. louise.savory@nhs.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21593809

Citation

Savory, Louise A., et al. "Selenium Supplementation and Exercise: Effect On Oxidant Stress in Overweight Adults." Obesity (Silver Spring, Md.), vol. 20, no. 4, 2012, pp. 794-801.
Savory LA, Kerr CJ, Whiting P, et al. Selenium supplementation and exercise: effect on oxidant stress in overweight adults. Obesity (Silver Spring). 2012;20(4):794-801.
Savory, L. A., Kerr, C. J., Whiting, P., Finer, N., McEneny, J., & Ashton, T. (2012). Selenium supplementation and exercise: effect on oxidant stress in overweight adults. Obesity (Silver Spring, Md.), 20(4), 794-801. https://doi.org/10.1038/oby.2011.83
Savory LA, et al. Selenium Supplementation and Exercise: Effect On Oxidant Stress in Overweight Adults. Obesity (Silver Spring). 2012;20(4):794-801. PubMed PMID: 21593809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium supplementation and exercise: effect on oxidant stress in overweight adults. AU - Savory,Louise A, AU - Kerr,Catherine J, AU - Whiting,Paul, AU - Finer,Nicholas, AU - McEneny,Jane, AU - Ashton,Tony, Y1 - 2011/05/19/ PY - 2011/5/20/entrez PY - 2011/5/20/pubmed PY - 2012/7/4/medline SP - 794 EP - 801 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 20 IS - 4 N2 - Both obesity and acute high-intensity exercise increase oxidant stress levels. This study investigates whether selenium (Se) supplementation could be a potential effective therapy to reduce obesity-associated oxidant stress and exercise-induced oxidant stress. Ten normal-weight (NW) (22.80 ± 0.41 kg/m(2)) and ten overweight (OW) healthy subjects (28.00 ± 0.81 kg/m(2)) were assessed during a randomized double-blind Se supplementation study (200 µg sodium selenite/day for 3 weeks) with a 3-week placebo control and inversion of treatment periods. Blood levels of lipid hydroperoxide (LH), superoxide dismutase (SOD), erythrocyte glutathione (GSH), and total antioxidant status (TAS), were measured at rest, pre-, and postexercise (30 min 70% VO(2) max before and after treatment (pretreatment (week 0 and 12) and post-treatment (week 3 or 15)). At rest, compared to placebo, Se supplementation had no significant effect on LH, SOD, GSH, and TAS levels. However, Se supplementation decreased LH levels in the OW group, immediately postexercise (-0.25 ± 0.12 µmol/l, P = 0.05) compared to placebo treatment. Postexercise, with or without Se supplementation, no changes in TAS, SOD, and GSH levels were observed in both the NW and OW group. This study has highlighted a potential benefit of Se in reducing LH levels postexercise in OW individuals. Given that oxidant stress is a predictor of coronary events, it is imperative to better understand oxidant stress-related responses to lifestyle factors (in particular "high-risk" population groups) and potential antioxidant therapy. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/21593809/Selenium_supplementation_and_exercise:_effect_on_oxidant_stress_in_overweight_adults_ L2 - https://doi.org/10.1038/oby.2011.83 DB - PRIME DP - Unbound Medicine ER -