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Bacterial etiology and serotypes of acute otitis media in Mexican children.
Vaccine 2011; 29(33):5544-9V

Abstract

Streptococcus pneumoniae and Haemophilus influenzae have been consistently reported to be the two major bacterial pathogens responsible for acute otitis media (AOM), mainly from studies in the US and Europe. However, data on bacterial pathogens causing AOM in Latin America are limited. Understanding the relative importance of these pathogens in a specific setting, the serotype distribution, and their antibiotic susceptibility levels is important to provide local vaccine and treatment recommendations. We therefore conducted a prospective, multi-center, tympanocentesis-based epidemiological study of Mexican children three months to less than five years of age. Fifty percent of episodes were in children who had received at least one dose of PCV7. Overall, 64% of samples were culture positive for bacterial pathogens. H. influenzae and S. pneumoniae were the leading causes of bacterial AOM, detected in 34% and 29% of AOM episodes, respectively. The most commonly isolated S. pneumoniae serotypes were 19A, 19F and 23F. All H. influenzae isolates were identified as non-typeable. Seventy-four percent of S. pneumoniae were susceptible to penicillin, while 97% were susceptible to amoxicillin/clavulanate. All H. influenzae samples were susceptible to amoxicillin/clavulanate and cefotaxime, 95% to cefuroxime and 75% to ampicillin. Both S. pneumoniae and non-typable H. influenzae represent important targets for vaccination strategies to reduce AOM in Mexican children.

Authors+Show Affiliations

Instituto Nacional de Pediatria, Insurgentes Sur 3700-C, Insurgentes Cuicuilco, México 04530, Mexico. mermacpar@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

21596081

Citation

Parra, Mercedes Macias, et al. "Bacterial Etiology and Serotypes of Acute Otitis Media in Mexican Children." Vaccine, vol. 29, no. 33, 2011, pp. 5544-9.
Parra MM, Aguilar GM, Echaniz-Aviles G, et al. Bacterial etiology and serotypes of acute otitis media in Mexican children. Vaccine. 2011;29(33):5544-9.
Parra, M. M., Aguilar, G. M., Echaniz-Aviles, G., Rionda, R. G., Estrada, M. d. e. . L., Cervantes, Y., ... Hausdorff, W. P. (2011). Bacterial etiology and serotypes of acute otitis media in Mexican children. Vaccine, 29(33), pp. 5544-9. doi:10.1016/j.vaccine.2011.04.128.
Parra MM, et al. Bacterial Etiology and Serotypes of Acute Otitis Media in Mexican Children. Vaccine. 2011 Jul 26;29(33):5544-9. PubMed PMID: 21596081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bacterial etiology and serotypes of acute otitis media in Mexican children. AU - Parra,Mercedes Macias, AU - Aguilar,Gerardo Martinez, AU - Echaniz-Aviles,Gabriela, AU - Rionda,Romulo Galo, AU - Estrada,Maria de Los Angeles Meza, AU - Cervantes,Yolanda, AU - Pirçon,Jean-Yves, AU - Van Dyke,Melissa K, AU - Colindres,Romulo E, AU - Hausdorff,William P, Y1 - 2011/05/17/ PY - 2011/02/04/received PY - 2011/04/15/revised PY - 2011/04/30/accepted PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2011/11/9/medline SP - 5544 EP - 9 JF - Vaccine JO - Vaccine VL - 29 IS - 33 N2 - Streptococcus pneumoniae and Haemophilus influenzae have been consistently reported to be the two major bacterial pathogens responsible for acute otitis media (AOM), mainly from studies in the US and Europe. However, data on bacterial pathogens causing AOM in Latin America are limited. Understanding the relative importance of these pathogens in a specific setting, the serotype distribution, and their antibiotic susceptibility levels is important to provide local vaccine and treatment recommendations. We therefore conducted a prospective, multi-center, tympanocentesis-based epidemiological study of Mexican children three months to less than five years of age. Fifty percent of episodes were in children who had received at least one dose of PCV7. Overall, 64% of samples were culture positive for bacterial pathogens. H. influenzae and S. pneumoniae were the leading causes of bacterial AOM, detected in 34% and 29% of AOM episodes, respectively. The most commonly isolated S. pneumoniae serotypes were 19A, 19F and 23F. All H. influenzae isolates were identified as non-typeable. Seventy-four percent of S. pneumoniae were susceptible to penicillin, while 97% were susceptible to amoxicillin/clavulanate. All H. influenzae samples were susceptible to amoxicillin/clavulanate and cefotaxime, 95% to cefuroxime and 75% to ampicillin. Both S. pneumoniae and non-typable H. influenzae represent important targets for vaccination strategies to reduce AOM in Mexican children. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21596081/Bacterial_etiology_and_serotypes_of_acute_otitis_media_in_Mexican_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00697-9 DB - PRIME DP - Unbound Medicine ER -