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Anticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds.
Fitoterapia. 2011 Sep; 82(6):811-7.F

Abstract

Blood coagulation consists of a series of zymogens that can be converted by limited proteolysis to active enzymes leading to the generation of thrombin. Fresh plasma and human thrombin was incubated with extracts from berries of Aronia melanocarpa or seeds of Vitis vinifera (0.5; 5; 50 μg/ml). The in vitro experiments showed that both extracts prolonged clotting time and decreased the maximal velocity of fibrin polymerization in human plasma. Moreover thrombin incubation with both extracts results in the inhibition of amidolytic activity of this enzyme. It gives hopes for development of diet supplements, which may be preventing thrombosis in pathological states.

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Authors+Show Affiliations

Bijak M
Department of General Biochemistry, University of Lodz, Banacha12/16, 90-237 Lodz, Poland. mbijak@biol.uni.lodz.pl
Bobrowski M
No affiliation info available
Borowiecka M
No affiliation info available
Podsędek A
No affiliation info available
Golański J
No affiliation info available
Nowak P
No affiliation info available

MeSH

AnticoagulantsFibrinFruitHumansPhotiniaPlant ExtractsPlatelet Aggregation InhibitorsPolymerizationPolyphenolsSeedsThrombinTime FactorsVitis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21596108

Citation

Bijak, Michał, et al. "Anticoagulant Effect of Polyphenols-rich Extracts From Black Chokeberry and Grape Seeds." Fitoterapia, vol. 82, no. 6, 2011, pp. 811-7.
Bijak M, Bobrowski M, Borowiecka M, et al. Anticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds. Fitoterapia. 2011;82(6):811-7.
Bijak, M., Bobrowski, M., Borowiecka, M., Podsędek, A., Golański, J., & Nowak, P. (2011). Anticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds. Fitoterapia, 82(6), 811-7. https://doi.org/10.1016/j.fitote.2011.04.017
Bijak M, et al. Anticoagulant Effect of Polyphenols-rich Extracts From Black Chokeberry and Grape Seeds. Fitoterapia. 2011;82(6):811-7. PubMed PMID: 21596108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticoagulant effect of polyphenols-rich extracts from black chokeberry and grape seeds. AU - Bijak,Michał, AU - Bobrowski,Mateusz, AU - Borowiecka,Marta, AU - Podsędek,Anna, AU - Golański,Jacek, AU - Nowak,Paweł, Y1 - 2011/05/06/ PY - 2010/12/30/received PY - 2011/04/18/revised PY - 2011/04/23/accepted PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2013/4/9/medline SP - 811 EP - 7 JF - Fitoterapia JO - Fitoterapia VL - 82 IS - 6 N2 - Blood coagulation consists of a series of zymogens that can be converted by limited proteolysis to active enzymes leading to the generation of thrombin. Fresh plasma and human thrombin was incubated with extracts from berries of Aronia melanocarpa or seeds of Vitis vinifera (0.5; 5; 50 μg/ml). The in vitro experiments showed that both extracts prolonged clotting time and decreased the maximal velocity of fibrin polymerization in human plasma. Moreover thrombin incubation with both extracts results in the inhibition of amidolytic activity of this enzyme. It gives hopes for development of diet supplements, which may be preventing thrombosis in pathological states. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/21596108/Anticoagulant_effect_of_polyphenols_rich_extracts_from_black_chokeberry_and_grape_seeds_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(11)00116-X DB - PRIME DP - Unbound Medicine ER -