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[Clinical features and prognosis of patients with scleroderma renal crisis].
Med Clin (Barc). 2011 Oct 15; 137(10):431-4.MC

Abstract

BACKGROUND AND OBJECTIVE

Scleroderma renal crisis is a severe complication of systemic sclerosis, which causes arterial hypertension and acute renal failure. Early treatment of these patients with ACE inhibitors may improve prognosis. We aimed to analyze the frequency, clinical and epidemiological characteristics, morbidity and mortality and prognosis of scleroderma renal crisis.

PATIENTS AND METHODS

Retrospective study of a cohort of 328 patients with SSc, of whom 194 had the limited form, 64 the diffuse form, 49 the sine scleroderma and 21 preescleroderma. We considered different subtypes of disease: limited (188), diffuse (63), scleroderma sine scleroderma (46) and preescleroderma (21). The data were obtained from a review of medical records. The differences in the prevalence of variables were analyzed by the Fisher's test.

RESULTS

A renal crisis was observed in 14 patients (4.26%), 3 men and 11 women, 64% had the diffuse form of the disease, 28% had the limited form, and 7.69% had the scleroderma sine scleroderma. The average time was 48 months. All received ACE inhibitors. The mortality was 85% (18 months) and 85% required dialysis.

CONCLUSIONS

Renal crisis is a rare manifestation of scleroderma which mainly affects patients with diffuse involvement of the disease in the early stages. These patients have a poor prognosis despite treatment with ACE inhibitors.

Authors+Show Affiliations

Servicio de Nefrología, Fundació Privada Hospital de Mollet, Mollet del Vallés, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

21596402

Citation

Roda-Safont, Amparo, et al. "[Clinical Features and Prognosis of Patients With Scleroderma Renal Crisis]." Medicina Clinica, vol. 137, no. 10, 2011, pp. 431-4.
Roda-Safont A, Simeón-Aznar CP, Fonollosa-Plà V, et al. [Clinical features and prognosis of patients with scleroderma renal crisis]. Med Clin (Barc). 2011;137(10):431-4.
Roda-Safont, A., Simeón-Aznar, C. P., Fonollosa-Plà, V., Segarra-Medrano, A., & Vilardell-Tarrés, M. (2011). [Clinical features and prognosis of patients with scleroderma renal crisis]. Medicina Clinica, 137(10), 431-4. https://doi.org/10.1016/j.medcli.2011.03.014
Roda-Safont A, et al. [Clinical Features and Prognosis of Patients With Scleroderma Renal Crisis]. Med Clin (Barc). 2011 Oct 15;137(10):431-4. PubMed PMID: 21596402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical features and prognosis of patients with scleroderma renal crisis]. AU - Roda-Safont,Amparo, AU - Simeón-Aznar,Carmen Pilar, AU - Fonollosa-Plà,Vicent, AU - Segarra-Medrano,Alfons, AU - Vilardell-Tarrés,Miquel, Y1 - 2011/05/18/ PY - 2010/12/23/received PY - 2011/03/03/revised PY - 2011/03/03/accepted PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2012/1/27/medline SP - 431 EP - 4 JF - Medicina clinica JO - Med Clin (Barc) VL - 137 IS - 10 N2 - BACKGROUND AND OBJECTIVE: Scleroderma renal crisis is a severe complication of systemic sclerosis, which causes arterial hypertension and acute renal failure. Early treatment of these patients with ACE inhibitors may improve prognosis. We aimed to analyze the frequency, clinical and epidemiological characteristics, morbidity and mortality and prognosis of scleroderma renal crisis. PATIENTS AND METHODS: Retrospective study of a cohort of 328 patients with SSc, of whom 194 had the limited form, 64 the diffuse form, 49 the sine scleroderma and 21 preescleroderma. We considered different subtypes of disease: limited (188), diffuse (63), scleroderma sine scleroderma (46) and preescleroderma (21). The data were obtained from a review of medical records. The differences in the prevalence of variables were analyzed by the Fisher's test. RESULTS: A renal crisis was observed in 14 patients (4.26%), 3 men and 11 women, 64% had the diffuse form of the disease, 28% had the limited form, and 7.69% had the scleroderma sine scleroderma. The average time was 48 months. All received ACE inhibitors. The mortality was 85% (18 months) and 85% required dialysis. CONCLUSIONS: Renal crisis is a rare manifestation of scleroderma which mainly affects patients with diffuse involvement of the disease in the early stages. These patients have a poor prognosis despite treatment with ACE inhibitors. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/21596402/[Clinical_features_and_prognosis_of_patients_with_scleroderma_renal_crisis]_ L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(11)00400-3 DB - PRIME DP - Unbound Medicine ER -