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Novel FDG-PET findings in anti-NMDA receptor encephalitis: a case based report.
J Child Neurol. 2011 Oct; 26(10):1325-8.JC

Abstract

The clinical manifestation and nuclear imaging findings in a 15-year-old boy with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis are described in this case report. The previously healthy patient presented with new onset hallucinations, seizure, and within a week, his mental status rapidly deteriorated to nonverbal with oro-lingual-facial dyskinesias. An extensive laboratory work-up for encephalopathy was negative. Repeated brain magnetic resonance imaging (MRI) studies were normal. On day 26 of admission, nuclear imaging using fluorodeoxyglucose positron emission tomography (FDG-PET) showed global hypometobolism with a prominent focally intense hypermetabolic lesion in the right cerebellar cortex. Diagnosis of anti-NMDAR encephalitis was confirmed with quantitative serology. The patient showed clinical signs of improvement after 2 courses of intravenous immunoglobulin therapy over 4 weeks. On day 46, repeat brain FDG-PET showed overall improvement but in contrast to the previous, the right cerebellar cortex showed focal hypometabolism. This is the first reported case of such findings using FDG-PET in anti-NMDAR encephalitis.

Authors+Show Affiliations

Department of Pediatrics and Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA. drmohsinch@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21596699

Citation

Maqbool, Mohsin, et al. "Novel FDG-PET Findings in anti-NMDA Receptor Encephalitis: a Case Based Report." Journal of Child Neurology, vol. 26, no. 10, 2011, pp. 1325-8.
Maqbool M, Oleske DA, Huq AH, et al. Novel FDG-PET findings in anti-NMDA receptor encephalitis: a case based report. J Child Neurol. 2011;26(10):1325-8.
Maqbool, M., Oleske, D. A., Huq, A. H., Salman, B. A., Khodabakhsh, K., & Chugani, H. T. (2011). Novel FDG-PET findings in anti-NMDA receptor encephalitis: a case based report. Journal of Child Neurology, 26(10), 1325-8. https://doi.org/10.1177/0883073811405199
Maqbool M, et al. Novel FDG-PET Findings in anti-NMDA Receptor Encephalitis: a Case Based Report. J Child Neurol. 2011;26(10):1325-8. PubMed PMID: 21596699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel FDG-PET findings in anti-NMDA receptor encephalitis: a case based report. AU - Maqbool,Mohsin, AU - Oleske,Deanna A, AU - Huq,A H M, AU - Salman,Bassel A, AU - Khodabakhsh,Kevin, AU - Chugani,Harry T, Y1 - 2011/05/19/ PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2012/2/9/medline SP - 1325 EP - 8 JF - Journal of child neurology JO - J Child Neurol VL - 26 IS - 10 N2 - The clinical manifestation and nuclear imaging findings in a 15-year-old boy with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis are described in this case report. The previously healthy patient presented with new onset hallucinations, seizure, and within a week, his mental status rapidly deteriorated to nonverbal with oro-lingual-facial dyskinesias. An extensive laboratory work-up for encephalopathy was negative. Repeated brain magnetic resonance imaging (MRI) studies were normal. On day 26 of admission, nuclear imaging using fluorodeoxyglucose positron emission tomography (FDG-PET) showed global hypometobolism with a prominent focally intense hypermetabolic lesion in the right cerebellar cortex. Diagnosis of anti-NMDAR encephalitis was confirmed with quantitative serology. The patient showed clinical signs of improvement after 2 courses of intravenous immunoglobulin therapy over 4 weeks. On day 46, repeat brain FDG-PET showed overall improvement but in contrast to the previous, the right cerebellar cortex showed focal hypometabolism. This is the first reported case of such findings using FDG-PET in anti-NMDAR encephalitis. SN - 1708-8283 UR - https://www.unboundmedicine.com/medline/citation/21596699/Novel_FDG_PET_findings_in_anti_NMDA_receptor_encephalitis:_a_case_based_report_ L2 - https://journals.sagepub.com/doi/10.1177/0883073811405199?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -