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Endomicroscopy in the evaluation of Barrett's esophagus.
Curr Opin Gastroenterol. 2011 Jul; 27(4):374-82.CO

Abstract

PURPOSE OF REVIEW

Confocal laser endomicroscopy (CLE) can provide real-time, microscopic visualization of the gastrointestinal mucosa, allowing an endoscopic approach to the histologic evaluation of Barrett's esophagus and Barrett's esophagus-associated neoplasia.

RECENT FINDINGS

Both endoscope-based (eCLE) and probe-based (pCLE) CLE systems have been used to evaluate Barrett's esophagus and Barrett's esophagus-associated neoplasia. Criteria for distinguishing Barrett's esophagus with neoplasia from nondysplastic Barrett's esophagus have been developed and validated for both eCLE and pCLE. Several studies have shown excellent detection of Barrett's esophagus neoplasia by CLE, and the technique may be used to guide endoscopic therapy. Advanced endomicroscopy systems and peptides and antibodies that target neoplasia are in development.

SUMMARY

CLE has provided a new way of evaluating Barrett's esophagus and Barrett's esophagus-associated neoplasia and is being used to improve detection and management of neoplasia in Barrett's esophagus.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, VA North Texas Healthcare System, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA. kerry.dunbar@va.gov

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21597371

Citation

Dunbar, Kerry B.. "Endomicroscopy in the Evaluation of Barrett's Esophagus." Current Opinion in Gastroenterology, vol. 27, no. 4, 2011, pp. 374-82.
Dunbar KB. Endomicroscopy in the evaluation of Barrett's esophagus. Curr Opin Gastroenterol. 2011;27(4):374-82.
Dunbar, K. B. (2011). Endomicroscopy in the evaluation of Barrett's esophagus. Current Opinion in Gastroenterology, 27(4), 374-82. https://doi.org/10.1097/MOG.0b013e328347bac4
Dunbar KB. Endomicroscopy in the Evaluation of Barrett's Esophagus. Curr Opin Gastroenterol. 2011;27(4):374-82. PubMed PMID: 21597371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endomicroscopy in the evaluation of Barrett's esophagus. A1 - Dunbar,Kerry B, PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2011/12/20/medline SP - 374 EP - 82 JF - Current opinion in gastroenterology JO - Curr. Opin. Gastroenterol. VL - 27 IS - 4 N2 - PURPOSE OF REVIEW: Confocal laser endomicroscopy (CLE) can provide real-time, microscopic visualization of the gastrointestinal mucosa, allowing an endoscopic approach to the histologic evaluation of Barrett's esophagus and Barrett's esophagus-associated neoplasia. RECENT FINDINGS: Both endoscope-based (eCLE) and probe-based (pCLE) CLE systems have been used to evaluate Barrett's esophagus and Barrett's esophagus-associated neoplasia. Criteria for distinguishing Barrett's esophagus with neoplasia from nondysplastic Barrett's esophagus have been developed and validated for both eCLE and pCLE. Several studies have shown excellent detection of Barrett's esophagus neoplasia by CLE, and the technique may be used to guide endoscopic therapy. Advanced endomicroscopy systems and peptides and antibodies that target neoplasia are in development. SUMMARY: CLE has provided a new way of evaluating Barrett's esophagus and Barrett's esophagus-associated neoplasia and is being used to improve detection and management of neoplasia in Barrett's esophagus. SN - 1531-7056 UR - https://www.unboundmedicine.com/medline/citation/21597371/Endomicroscopy_in_the_evaluation_of_Barrett's_esophagus_ L2 - http://dx.doi.org/10.1097/MOG.0b013e328347bac4 DB - PRIME DP - Unbound Medicine ER -