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Depression and neurocognitive performance in Portuguese patients infected with HIV.
AIDS Behav. 2011 Nov; 15(8):1879-87.AB

Abstract

This study focused on neurocognitive disorders associated with HIV infection, characterizes the most affected neuropsychological domains and their potential as factors related with depression. 130 HIV-positive individuals with CD4 >200 cells/mm(3), undetectable viral load, treated with HAART and with all kinds of risk behaviors were included. A structured interview composed by seven sections was used and relevant clinical and laboratory data was assessed. For the neuropsychological and depression assessment the HIV Neurobehavioral Research Center (HNRC) Battery and Hamilton Rating Scale for Depression (HAM-D) were chosen. Univariate nonparametric statistics and multivariate regression model were performed. Among 34% of depressed subjects, 20.7% had attempted suicide, 45.4% were under psychiatric medication and only 19% had no diagnostic criteria for HIV Associated Neurocognitive Disorders (HAND). The effect of depression on cognitive function revealed a significant deterioration in five of the eight measures. In the multivariate analysis, five variables significantly determined depression: sex, social class, antidepressant medication, history of suicide attempt and Dexterity and motor speed (neuropsychological test battery). Despite good patient adherence to treatment (HAART and antidepressive) and good immune status, the prevalence of HAND and depression are high and suggest a significant relation between severity of depression and cognitive functioning.

Authors+Show Affiliations

Department of Psychiatry, Oporto Medical School, Porto, Portugal. miguelbraganca@netcabo.ptNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21598031

Citation

Bragança, Miguel, and António Palha. "Depression and Neurocognitive Performance in Portuguese Patients Infected With HIV." AIDS and Behavior, vol. 15, no. 8, 2011, pp. 1879-87.
Bragança M, Palha A. Depression and neurocognitive performance in Portuguese patients infected with HIV. AIDS Behav. 2011;15(8):1879-87.
Bragança, M., & Palha, A. (2011). Depression and neurocognitive performance in Portuguese patients infected with HIV. AIDS and Behavior, 15(8), 1879-87. https://doi.org/10.1007/s10461-011-9973-3
Bragança M, Palha A. Depression and Neurocognitive Performance in Portuguese Patients Infected With HIV. AIDS Behav. 2011;15(8):1879-87. PubMed PMID: 21598031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and neurocognitive performance in Portuguese patients infected with HIV. AU - Bragança,Miguel, AU - Palha,António, PY - 2011/5/21/entrez PY - 2011/5/21/pubmed PY - 2011/12/20/medline SP - 1879 EP - 87 JF - AIDS and behavior JO - AIDS Behav VL - 15 IS - 8 N2 - This study focused on neurocognitive disorders associated with HIV infection, characterizes the most affected neuropsychological domains and their potential as factors related with depression. 130 HIV-positive individuals with CD4 >200 cells/mm(3), undetectable viral load, treated with HAART and with all kinds of risk behaviors were included. A structured interview composed by seven sections was used and relevant clinical and laboratory data was assessed. For the neuropsychological and depression assessment the HIV Neurobehavioral Research Center (HNRC) Battery and Hamilton Rating Scale for Depression (HAM-D) were chosen. Univariate nonparametric statistics and multivariate regression model were performed. Among 34% of depressed subjects, 20.7% had attempted suicide, 45.4% were under psychiatric medication and only 19% had no diagnostic criteria for HIV Associated Neurocognitive Disorders (HAND). The effect of depression on cognitive function revealed a significant deterioration in five of the eight measures. In the multivariate analysis, five variables significantly determined depression: sex, social class, antidepressant medication, history of suicide attempt and Dexterity and motor speed (neuropsychological test battery). Despite good patient adherence to treatment (HAART and antidepressive) and good immune status, the prevalence of HAND and depression are high and suggest a significant relation between severity of depression and cognitive functioning. SN - 1573-3254 UR - https://www.unboundmedicine.com/medline/citation/21598031/Depression_and_neurocognitive_performance_in_Portuguese_patients_infected_with_HIV_ L2 - https://doi.org/10.1007/s10461-011-9973-3 DB - PRIME DP - Unbound Medicine ER -